Evidence map›Paper›PMID 28542109›Full record

ReviewCurrent opinion in organ transplantation2017

Application and interpretation of histocompatibility data in pediatric kidney transplantation.

Hilda E Fernandez

Abstract readReview
In one paragraph

Review in Current opinion in organ transplantation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Hilda E FernandezDivision of Nephrology, Department of Medicine, Columbia University Medical Center, New York, New York, USA.

Funding

Ancestry, Genetic Risk and Health Disparities in Immune-Mediated NephritisR01MD009223 · NIMHD · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BOMBACK, ANDREW STEPHEN, GHARAVI, ALI G · 2014 to 2018
$2.2M
NIMHD NIH HHS R01 MD009223
6 · The paper itself

Abstract

purpose of reviewAdvances in technology to assess immunologic risk in solid organ transplant offer an opportunity to optimize the approach to pediatric deceased donor kidney transplant in the setting of a new allocation system in the United States. RECENT

findingsDegree of human leukocyte antigen (HLA) mismatch, class II HLA mismatch, unacceptable antigens and donor-specific antibody (DSA) detected by solid-phase assays, and epitope matching pretransplant affect pediatric kidney transplant outcomes. Detection of de novo DSAs (dnDSAs) posttransplant has been associated with increased risk of acute rejection and worse allograft function. Development of dnDSA occurs in recipients with greater epitope mismatching. SUMMARY: Improved long-term outcomes may be anticipated in pediatric kidney transplant recipients by incorporating extended HLA mismatch information and updating the clinical approach to donor kidney matching using available technology to identify clinically relevant immunologic risk.

Indexed as

AntibodiesChildHistocompatibilityHistocompatibility TestingHLA AntigensHumansKidney TransplantationAntibodiesHLA Antigens

Identifiers

PMID28542109
PMCPMC5570535

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.