ArticleInvestigative radiology2017
Magnetization Transfer Magnetic Resonance Imaging Noninvasively Detects Renal Fibrosis in Swine Atherosclerotic Renal Artery Stenosis at 3.0 T.
Article in Investigative radiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 31 citations in OpenAlex.
- Unmasking Early Hepatorenal Fibrosis in Polycystic Kidney Disease Using Noninvasive Precision Molecular MRI of Collagen.bioRxiv : the preprint server for biology · 2026Article
- MT-MRI for detection of renal interstitial fibrosis in renovascular disease.Scientific reports · 2026Article
- Rotating Frame Relaxation Time Mapping for the Visualization of the Sinoatrial Node Without Contrast Agent.NMR in biomedicine · 2025Article
- Advances in imaging techniques to assess kidney fibrosis.Renal failure · 2023Review
- Assessment of rhabdomyolysis-induced acute kidney injury with chemical exchange saturation transfer magnetic resonance imaging.Quantitative imaging in medicine and surgery · 2023Article
- Evaluation of Renal Fibrosis Using Magnetization Transfer Imaging at 1.5T and 3T in a Porcine Model of Renal Artery Stenosis.Journal of clinical medicine · 2023Article
- Noninvasively differentiating acute and chronic nephropathies via multiparametric urea-CEST, nuclear Overhauser enhancement-CEST, and quantitative magnetization transfer MRI.Magnetic resonance in medicine · 2023Article
- High Contrast Detection of Carotid Neothrombus with Strong Near-Infrared Absorption Selenium Nanosphere Enhanced Photoacoustic Imaging.International journal of nanomedicine · 2023Article
- Reliable Assessment of Swine Renal Fibrosis Using Quantitative Magnetization Transfer Imaging.Investigative radiology · 2022Article
- Test-retest assessment of non-contrast MRI sequences to characterise and quantify the small bowel wall in healthy participants.Magma (New York, N.Y.) · 2021Article
- 3D magnetization transfer (MT) for the visualization of cardiac free-running Purkinje fibers: an ex vivo proof of concept.Magma (New York, N.Y.) · 2021Article
- A 3D high resolution MRI method for the visualization of cardiac fibro-fatty infiltrations.Scientific reports · 2021Article
- Quantitative Magnetization Transfer Detects Renal Fibrosis in Murine Kidneys With Renal Artery Stenosis.Journal of magnetic resonance imaging : JMRI · 2020Article
- Mesenchymal Stem/Stromal Cells and their Extracellular Vesicle Progeny Decrease Injury in Poststenotic Swine Kidney Through Different Mechanisms.Stem cells and development · 2020Article
- Role of Chemical Exchange Saturation Transfer and Magnetization Transfer MRI in Detecting Metabolic and Structural Changes of Renal Fibrosis in an Animal Model at 3T.Korean journal of radiology · 2020Article
- Article
- Noninvasive quantitative magnetization transfer MRI reveals tubulointerstitial fibrosis in murine kidney.NMR in biomedicine · 2019Article
- Magnetization Transfer Imaging Is Unaffected by Decreases in Renal Perfusion in Swine.Investigative radiology · 2019Article
- Noninvasive assessment of renal fibrosis by magnetic resonance imaging and ultrasound techniques.Translational research : the journal of laboratory and clinical medicine · 2019Review
- Multiparametric Functional Magnetic Resonance Imaging for Evaluating Renal Allograft Injury.Korean journal of radiology · 2019Review
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
objectivesRenal fibrosis is a useful biomarker for diagnosis and evaluation of therapeutic interventions of renal diseases but often requires invasive testing. Magnetization transfer magnetic resonance imaging (MT-MRI), which evaluates the presence of macromolecules, offers a noninvasive tool to probe renal fibrosis in murine renal artery stenosis (RAS) at 16.4 T. In this study, we aimed to identify appropriate imaging parameters for collagen detection at 3.0 T MRI and to test the utility of MT-MRI in measuring renal fibrosis in a swine model of atherosclerotic RAS (ARAS). MATERIALS AND
methodsTo select the appropriate offset frequency, an MT-MRI study was performed on a phantom containing 0% to 40% collagen I and III with offset frequencies from -1600 to +1600 Hz and other MT parameters empirically set as pulse width at 16 milliseconds and flip angle at 800 degrees. Then selected MT parameters were used in vivo on pigs 12 weeks after sham (n = 8) or RAS (n = 10) surgeries. The ARAS pigs were fed with high-cholesterol diet to induce atherosclerosis. The MT ratio (MTR) was compared with ex vivo renal fibrosis measured using Sirius-red staining.
resultsOffset frequencies at 600 and 1000 Hz were selected for collagen detection without direct saturation of free water signal, and subsequently applied in vivo. The ARAS kidneys showed mild cortical and medullary fibrosis by Sirius-red staining. The cortical and medullary MTRs at 600 and 1000 Hz were both increased. Renal fibrosis measured ex vivo showed good linear correlations with MTR at 600 (cortex: Pearson correlation coefficient r = 0.87, P < 0.001; medulla: r = 0.70, P = 0.001) and 1000 Hz (cortex: r = 0.75, P < 0.001; medulla: r = 0.83, P < 0.001).
conclusionsMagnetization transfer magnetic resonance imaging can noninvasively detect renal fibrosis in the stenotic swine kidney at 3.0 T. Therefore, MT-MRI may potentially be clinically applicable and useful for detection and monitoring of renal pathology in subjects with RAS.
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