ArticleCritical care medicine2017
The Impact of the Sepsis-3 Septic Shock Definition on Previously Defined Septic Shock Patients.
Article in Critical care medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
43 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Continuous versus Intermittent Hydrocortisone for the Treatment of Septic Shock: A Systematic Review and Meta-Analysis.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2026Pooled it
- All-cause mortality in cancer patients treated for sepsis in intensive care units: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022Pooled it
- Propafenone versus amiodarone for supraventricular arrhythmias in septic shock: a randomised controlled trial.Intensive care medicine · 2023Trial
- Estrogen receptor β deficiency increases susceptibility to sepsis through metabolic reprogramming-induced macrophage pyroptosis.The Journal of clinical investigation · 2026Article
- Continuous vs. intermittent infusion of corticosteroids in septic shock: a GRADE-based systematic review and meta-analysis.Journal of anesthesia, analgesia and critical care · 2026Review
- An Easy and Quick Risk-Stratified Early Forewarning Model for Septic Shock in the Intensive Care Unit: Development, Validation, and Interpretation Study.Journal of medical Internet research · 2025Article
- Influence of hydrocortisone infusion method on the clinical outcome of patients with septic shock: A systematic review and meta-analysis.Journal of intensive medicine · 2025Article
- Enhancing SAPS-3 Predictive Accuracy with Initial, Peak, and Last Lactate Measurements in Septic Shock.Journal of clinical medicine · 2024Article
- Long-Term Survival of Patients With Cancer, Sepsis, and Vasopressor Requirements Based on Lactate Levels.Critical care explorations · 2024Article
- More attention should be paid to Omicron-associated sepsis: a multicenter retrospective study in south China.Journal of thoracic disease · 2024Article
- Cefiderocol Treatment for Severe Infections due to Difficult-to-Treat-Resistant Non-Fermentative Gram-Negative Bacilli in ICU Patients: A Case Series and Narrative Literature Review.Antibiotics (Basel, Switzerland) · 2023Review
- Alert to Action: Implementing Artificial Intelligence-Driven Clinical Decision Support Tools for Sepsis.Ochsner journal · 2023Article
- Risk Factors for Mortality in Sepsis Patients without Lactate Levels Increasing Early.Emergency medicine international · 2023Article
- Article
- Identifying and analyzing sepsis states: A retrospective study on patients with sepsis in ICUs.PLOS digital health · 2022Article
- Article
- Septic shock 3.0 criteria application in severe COVID-19 patients: An unattended sepsis population with high mortality risk.World journal of critical care medicine · 2022Article
- Characteristics of Sepsis-2 septic shock patients failing to satisfy the Sepsis-3 septic shock definition: an analysis of real-time collected data.Annals of intensive care · 2021Article
- Molecular mechanisms in septic shock (Review).Experimental and therapeutic medicine · 2021Review
- Protective effect of taurine on sepsis‑induced lung injury via inhibiting the p38/MAPK signaling pathway.Molecular medicine reports · 2021Article
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Authors and funding
5 authors.
Funding
Abstract
objectiveThe Third International Consensus Definitions Task Force (Sepsis-3) recently recommended changes to the definitions of sepsis. The impact of these changes remains unclear. Our objective was to determine the outcomes of patients meeting Sepsis-3 septic shock criteria versus patients meeting the "old" (1991) criteria of septic shock only.
designSecondary analysis of two clinical trials of early septic shock resuscitation.
settingLarge academic emergency departments in the United States. PATIENTS: Patients with suspected infection, more than or equal to two systemic inflammatory response syndrome criteria, and systolic blood pressure less than 90 mm Hg after fluid resuscitation.
interventionsPatients were further categorized as Sepsis-3 septic shock if they demonstrated hypotension, received vasopressors, and exhibited a lactate greater than 2 mmol/L. We compared in-hospital mortality in patients who met the old definition only with those who met the Sepsis-3 criteria. MEASUREMENTS AND MAIN
resultsFour hundred seventy patients were included in the present analysis. Two hundred (42.5%) met Sepsis-3 criteria, whereas 270 (57.4%) met only the old definition. Patients meeting Sepsis-3 criteria demonstrated higher severity of illness by Sequential Organ Failure Assessment score (9 vs 5; p < 0.001) and mortality (29% vs 14%; p < 0.001). Subgroup analysis of 127 patients meeting only the old definition demonstrated significant mortality benefit following implementation of a quantitative resuscitation protocol (35% vs 10%; p = 0.006).
conclusionIn this analysis, 57% of patients meeting old definition for septic shock did not meet Sepsis-3 criteria. Although Sepsis-3 criteria identified a group of patients with increased organ failure and higher mortality, those patients who met the old criteria and not Sepsis-3 criteria still demonstrated significant organ failure and 14% mortality rate.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.