ArticleMolecular and cellular biology1988
A Ty1 cell-type-specific regulatory sequence is a recognition element for a constitutive binding factor.
Article in Molecular and cellular biology, 1988. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 37 citations in OpenAlex.
- Ty3 Retrotransposon Hijacks Mating Yeast RNA Processing Bodies to Infect New Genomes.PLoS genetics · 2015Article
- Review
- The pheromone response pathway activates transcription of Ty5 retrotransposons located within silent chromatin of Saccharomyces cerevisiae.The EMBO journal · 1997Article
- Isolation and analysis of the yeast TEA1 gene, which encodes a zinc cluster Ty enhancer-binding protein.Molecular and cellular biology · 1996Article
- Yeast MEK-dependent signal transduction: response thresholds and parameters affecting fidelity.Molecular and cellular biology · 1995Article
- Functional coupling of a mammalian somatostatin receptor to the yeast pheromone response pathway.Molecular and cellular biology · 1995Article
- Migration of the yeast linear DNA plasmid from the cytoplasm into the nucleus in Saccharomyces cerevisiae.Current genetics · 1995Article
- The Aspergillus nidulans abaA gene encodes a transcriptional activator that acts as a genetic switch to control development.Molecular and cellular biology · 1994Article
- Involvement of SRE element of Ty1 transposon in TEC1-dependent transcriptional activation.Nucleic acids research · 1994Article
- The Aspergillus nidulans yA gene is regulated by abaA.The EMBO journal · 1993Article
- Role of Saccharomyces cerevisiae Rap1 protein in Ty1 and Ty1-mediated transcription.Gene expression · 1993Article
- MCM1 binds to a transcriptional control element in Ty1.Molecular and cellular biology · 1993Article
- SPT13 (GAL11) of Saccharomyces cerevisiae negatively regulates activity of the MCM1 transcription factor in Ty1 elements.Molecular and cellular biology · 1993Article
- Characterization of trans-acting mutations affecting Ty and Ty-mediated transcription in Saccharomyces cerevisiae.Current genetics · 1991Article
- Both activation and repression of a-mating-type-specific genes in yeast require transcription factor Mcm1.Proceedings of the National Academy of Sciences of the United States of America · 1991Article
- TEC1, a gene involved in the activation of Ty1 and Ty1-mediated gene expression in Saccharomyces cerevisiae: cloning and molecular analysis.Molecular and cellular biology · 1990Article
- The Saccharomyces cerevisiae SPT13/GAL11 gene has both positive and negative regulatory roles in transcription.Molecular and cellular biology · 1989Article
- Enhancer and silencerlike sites within the transcribed portion of a Ty2 transposable element of Saccharomyces cerevisiae.Molecular and cellular biology · 1989Article
- The Saccharomyces cerevisiae PUT3 activator protein associates with proline-specific upstream activation sequences.Molecular and cellular biology · 1989Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Ty transposable-element insertion mutations of Saccharomyces cerevisiae can cause cell-type-dependent activation of adjacent-gene expression. Several cis-acting regulatory regions within Ty1 are responsible for the effect of Ty1 on adjacent-gene expression. One of these is the block II sequence that was defined by its homology to mammalian enhancers and to the yeast a1-alpha 2 control site. Tandem copies of a 57-base-pair region encompassing block II caused an additive increase in expression of the CYC7 reporter gene in the absence of other Ty1 sequences. The activation of gene expression by the multiple repeats was abolished in a/alpha diploid cells. A specific complex between a constitutive factor in whole-cell extracts and the DNA regulatory element was observed. The protein-binding site for the constitutive factor coincided with the block II element. Base-pair substitutions within the binding site abolished the ability of the block II element to function as a component of the Ty1 activator and to form the factor-DNA complex. The correlation between complex formation and reporter gene expression indicates that factor binding to the cis-acting element is essential for this element to function as a component of the Ty1 activator.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.