Evidence map›Paper›PMID 28541890›Full record

ArticleIEEE transactions on bio-medical engineering2018

Event-Triggered Model Predictive Control for Embedded Artificial Pancreas Systems.

Ankush Chakrabarty, Stamatina Zavitsanou, Francis J Doyle, Eyal Dassau

Open access · greenAbstract read
In one paragraph

Article in IEEE transactions on bio-medical engineering, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
9.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 96 citations in OpenAlex.

  1. Article
  2. Article
  3. Enhancement of Closed-Loop Cognitive Stress Regulation Using Supervised Control Architectures.IEEE open journal of engineering in medicine and biology · 2022
    Article
  4. Article
  5. Article
  6. Embedded Model Predictive Control for a Wearable Artificial Pancreas.IEEE transactions on control systems technology : a publication of the IEEE Control Systems Society · 2020
    Article
  7. Online Glucose Prediction Using Computationally Efficient Sparse Kernel Filtering Algorithms in Type-1 Diabetes.IEEE transactions on control systems technology : a publication of the IEEE Control Systems Society · 2020
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Ankush Chakrabarty
Stamatina Zavitsanou
Francis J Doyle
Eyal Dassau
Harvard University · US

Funding

On-body ecosystem for automated insulin delivery in type 1 diabetesDP3DK113511 · NIDDK · YALE UNIVERSITY · PI DASSAU, EYAL, LAFFEL, LORI M · 2017 to 2017
$3.0M
An Implanted Intraperitoneal (IP-IP) Artificial Pancreas; a quantum leap forwardDP3DK101068 · NIDDK · UNIVERSITY OF CALIFORNIA SANTA BARBARA · PI ZISSER, HOWARD · 2013 to 2016
$2.6M
Pediatric Artificial Pancreas System for Enhanced Diabetes Management in Young Children with Type 1 DiabetesDP3DK104057 · NIDDK · UNIVERSITY OF CALIFORNIA SANTA BARBARA · PI DASSAU, EYAL, DOYLE, FRANCIS J · 2014 to 2014
$1.8M
NIDDK NIH HHS DP3 DK101068NIDDK NIH HHS DP3 DK104057NIDDK NIH HHS DP3 DK113511
6 · The paper itself

Abstract

objectiveThe development of artificial pancreas (AP) technology for deployment in low-energy, embedded devices is contingent upon selecting an efficient control algorithm for regulating glucose in people with type 1 diabetes mellitus. In this paper, we aim to lower the energy consumption of the AP by reducing controller updates, that is, the number of times the decision-making algorithm is invoked to compute an appropriate insulin dose.

methodsPhysiological insights into glucose management are leveraged to design an event-triggered model predictive controller (MPC) that operates efficiently, without compromising patient safety. The proposed event-triggered MPC is deployed on a wearable platform. Its robustness to latent hypoglycemia, model mismatch, and meal misinformation is tested, with and without meal announcement, on the full version of the US-FDA accepted UVA/Padova metabolic simulator.

resultsThe event-based controller remains on for 18 h of 41 h in closed loop with unannounced meals, while maintaining glucose in 70-180 mg/dL for 25 h, compared to 27 h for a standard MPC controller. With meal announcement, the time in 70-180 mg/dL is almost identical, with the controller operating a mere 25.88% of the time in comparison with a standard MPC.

conclusionA novel control architecture for AP systems enables safe glycemic regulation with reduced processor computations. SIGNIFICANCE: Our proposed framework integrated seamlessly with a wide variety of popular MPC variants reported in AP research, customizes tradeoff between glycemic regulation and efficacy according to prior design specifications, and eliminates judicious prior selection of controller sampling times.

Indexed as

Models, StatisticalPancreas, ArtificialAlgorithmsBlood Glucose Self-MonitoringDiabetes Mellitus, Type 1HumansHypoglycemiaHypoglycemic AgentsHypoglycemic Agents

Identifiers

PMID28541890
PMCPMC5839516
OpenAlexW2620014678

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.