Evidence map›Paper›PMID 28541802›Full record

Trial reportJournal of dual diagnosis

The Role of Relationship Adjustment in an Integrated Individual Treatment for PTSD and Substance Use Disorders Among Veterans: An Exploratory Study.

Julianne C Flanagan, Melanie S Fischer, Christal L Badour, Gili Ornan, Therese K Killeen, Sudie E Back

Registry-linked trialAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Journal of dual diagnosis. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01365247 (A Randomized Trial of Concurrent Treatment for PTSD and Substance Dependence), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01365247 nacompletednot on this map

A Randomized Trial of Concurrent Treatment for PTSD and Substance Dependence

TypeinterventionalSponsorThe City College of New YorkRan2008 to 2014Enrolled110ConditionsStress Disorders, Post-Traumatic, Substance-Related DisordersArmsConcurrent Treatment of PTSD and Substance Use Disorders Using Prolonged Exposure, Relapse Prevention Treatment, Active Monitoring Control Group
3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Julianne C Flanagana Department of Psychiatry & Behavioral Sciences , Medical University of South Carolina , Charleston , South Carolina , USA.
Melanie S Fischera Department of Psychiatry & Behavioral Sciences , Medical University of South Carolina , Charleston , South Carolina , USA.
Christal L Badourb Department of Psychology , University of Kentucky , Lexington , Kentucky , USA.
Gili Ornanc Case Western Reserve University , Cleveland , Ohio , USA.
Therese K Killeena Department of Psychiatry & Behavioral Sciences , Medical University of South Carolina , Charleston , South Carolina , USA.
Sudie E Backa Department of Psychiatry & Behavioral Sciences , Medical University of South Carolina , Charleston , South Carolina , USA.

Funding

Drug Abuse Research Training (DART) ProgramR25DA020537 · NIDA · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI KATHLEEN T. BRADY, Sudie E Back · 2006 to 2026
$6.3M
Integrated Treatment of OEF/OIF Veterans with PTSD and Substance Use DisordersR01DA030143 · NIDA · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI BACK, SUDIE E · 2010 to 2014
$1.6M
Integrating Neurobiology and Neuroimaging into Research on Addiction and PTSDK02DA039229 · NIDA · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI BACK, SUDIE E · 2015 to 2019
$779k
Effects of Oxytocin on Alcohol Craving and Intimate Partner AggressionK23AA023845 · NIAAA · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI FLANAGAN, JULIANNE CHRISTINA · 2016 to 2019
$774k
NIAAA NIH HHS K23 AA023845NIDA NIH HHS K02 DA039229NIDA NIH HHS R01 DA030143NIDA NIH HHS R25 DA020537
6 · The paper itself

Abstract

objectiveIdentifying factors that influence treatment outcomes of emerging integrated interventions for co-occurring posttraumatic stress disorder (PTSD) and substance use disorder is crucial to maximize veterans' health. Dyadic adjustment suffers among individuals with PTSD and substance use disorder and may be an important mechanism of change in treatment. This exploratory study examined the association between dyadic adjustment and treatment outcomes in individual integrated treatment for co-occurring PTSD and substance use disorder.

methodsParticipants were treatment-seeking veterans (N = 15) participating in a larger randomized controlled trial examining the efficacy of a novel integrated treatment for co-occurring PTSD and substance use disorder. Multiple regression analyses controlling for baseline symptom severity and independent sample t-tests were used to examine the relation between dyadic adjustment and treatment outcome variables including PTSD, substance use disorder, and depression symptom severity.

resultsBaseline dyadic adjustment was associated with session 12 PTSD symptom severity as measured by both the Clinician-Administered PTSD Scale (CAPS) and PTSD Checklist (PCL), such that participants with high dyadic adjustment had significantly lower session 12 CAPS and PCL scores compared to participants with low dyadic adjustment. Baseline dyadic adjustment was not associated with session 12 depression symptoms or frequency of substance use.

conclusionsThese findings suggest that while the primary determinant of treatment outcome in this sample is the application of an evidence-based intervention, dyadic adjustment may play a role in individual treatment outcome for some treatment-seeking veterans. Data from this study were derived from clinical trial NCT01365247.

Indexed as

Delivery of Health Care, IntegratedPrecision MedicineAdolescentAdultAgedFemaleHumansMaleMiddle AgedPsychiatric Status Rating ScalesRegression AnalysisSeverity of Illness IndexStress Disorders, Post-TraumaticSubstance-Related DisordersTreatment OutcomeVeteransaddictioncouplesdyadic adjustmentintegrated treatmentposttraumatic stress

Identifiers

PMID28541802
PMCPMC5544565

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.