ArticleNeuro-oncology2017
Disrupted development and integrity of frontal white matter in patients treated for pediatric medulloblastoma.
Article in Neuro-oncology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 22 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Diffusion tensor imaging indices as biomarkers for cognitive changes following paediatric radiotherapy: a systematic review and meta-analysis.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2022Pooled it
- Neuroimaging Biomarkers and Neurocognitive Outcomes in Pediatric Medulloblastoma Patients: a Systematic Review.Cerebellum (London, England) · 2021Pooled it
- Executive function after childhood cancer: Insights from network neuroscience.Neuro-oncology advances · 2026Review
- Single-Nucleus RNA Sequencing of HDAC6 Inhibition in Resolving Doxorubicin-Induced Cognitive Impairment.Molecular neurobiology · 2025Article
- Characterizing long-term neurocognitive outcomes through diffusion tensor imaging in childhood brain tumor survivors.Neuro-oncology · 2025Article
- Long-term neurocognitive sequelae in pediatric medulloblastoma survivors treated according to the HIT protocol.Journal of neuro-oncology · 2025Article
- MRI identifies disrupted cerebral development in medulloblastoma patients.Brain communications · 2025Article
- Imaging mediation analysis for longitudinal outcomes: a case study of childhood brain tumor survivorship.Statistics and its interface · 2024Article
- Neurocognitive Dysfunction After Treatment for Pediatric Brain Tumors: Subtype-Specific Findings and Proposal for Brain Network-Informed Evaluations.Neuroscience bulletin · 2023Review
- Toxicity and Clinical Results after Proton Therapy for Pediatric Medulloblastoma: A Multi-Centric Retrospective Study.Cancers · 2022Article
- Association Between Brain Substructure Dose and Cognitive Outcomes in Children With Medulloblastoma Treated on SJMB03: A Step Toward Substructure-Informed Planning.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2022Article
- White matter tract changes in pediatric posterior fossa brain tumor survivors after surgery and chemotherapy.Frontiers in neuroimaging · 2022Article
- Immunotherapy in Medulloblastoma: Current State of Research, Challenges, and Future Perspectives.Cancers · 2021Review
- Cerebellar-Subcortical-Cortical Systems as Modulators of Cognitive Functions.Neuropsychology review · 2021Review
- White matter hyperintensity volumes are related to processing speed in long-term survivors of childhood cerebellar tumors.Journal of neuro-oncology · 2021Article
- Brain Imaging in Pediatric Cancer Survivors: Correlates of Cognitive Impairment.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2021Review
- Early neuropsychological profile of children diagnosed with a brain tumor predicts later academic difficulties at school age.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2021Article
- Neuroimaging of the component white matter connections and structures within the cerebellar-frontal pathway in posterior fossa tumor survivors.NeuroImage. Clinical · 2019Article
- Early changes in white matter predict intellectual outcome in children treated for posterior fossa tumors.NeuroImage. Clinical · 2018Article
- Evidence of supratentorial white matter injury prior to treatment in children with posterior fossa tumors using diffusion MRI.Neuro-oncology advancesArticle
Corrections and comments
- Erratum issuedCorrigendum.2017
Authors and funding
9 authors.
Funding
Abstract
backgroundTreatment of pediatric medulloblastoma is associated with known neurocognitive deficits that we hypothesize are caused by microstructural damage to frontal white matter (WM).
methodsLongitudinal MRI examinations were collected from baseline (after surgery but before therapy) to 36 months in 146 patients and at 3 time points in 72 controls. Regional analyses of frontal WM volume and diffusion tensor imaging metrics were performed and verified with tract-based spatial statistics. Age-adjusted, linear mixed-effects models were used to compare patient and control images and to associate imaging changes with Woodcock-Johnson Tests of Cognitive Abilities.
resultsAt baseline, WM volumes in patients were similar to those in controls; fractional anisotropy (FA) was lower bilaterally (P < 0.001) and was associated with decreased Processing Speed (P = 0.014) and Broad Attention (P = 0.025) performance at 36 months. During follow-up, WM volumes increased in controls but decreased in patients (P < 0.001) bilaterally. Smaller WM volumes in patients at 36 months were associated with concurrent decreased Working Memory (P = 0.026) performance.
conclusionsLower FA in patients with pediatric medulloblastoma compared with age-similar controls indicated that patients suffer substantial acute microstructural damage to supratentorial frontal WM following surgery but before radiation therapy or chemotherapy. Additionally, this damage to the frontal WM was associated with decreased cognitive performance in executive function 36 months later. This early damage also likely contributed to posttherapeutic failure of age-appropriate WM development and to the known association between decreased WM volumes and decreased cognitive performance.
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