ArticleJournal of radiation research2017
Differences in responses to X-ray exposure between osteoclast and osteoblast cells.
Article in Journal of radiation research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 41 citations in OpenAlex.
- Targeted Alpha Therapy as a Multiscale Design Problem: From Radioactive Decay to Therapeutic Outcome.Pharmaceuticals (Basel, Switzerland) · 2026Review
- Quantifying early pelvic radiation-induced bone injury with dual-energy CT: a rabbit model study of dynamic bone mineral and marrow adiposity changes.Frontiers in medicine · 2026Article
- Disrupted bone microenvironment and immune recovery following total body irradiation in a murine model.Cell death & disease · 2025Article
- Bystander Effects in Osteoblasts and Osteoclasts: Comparison Between X- and Proton-Irradiation.International journal of particle therapy · 2025Article
- The effects of high-dose radiation therapy on bone: a scoping review.Radiation oncology journal · 2024Article
- Cytoprotective Effect of Gallic Acid against Injuries Promoted by Therapeutic Ionizing Radiation in Preosteoblast Cells.International journal of molecular and cellular medicine · 2024Article
- The effects of BPA-BNCT on normal bone: determination of the CBE value in mice‡.Journal of radiation research · 2023Article
- Radiation Induces Bone Microenvironment Disruption by Activating the STING-TBK1 Pathway.Medicina (Kaunas, Lithuania) · 2023Article
- Article
- Modulation of Differentiation and Bone Resorbing Activity of Human (Pre-) Osteoclasts After X-Ray Exposure.Frontiers in immunology · 2022Article
- Simulated Galactic Cosmic Rays Modify Mitochondrial Metabolism in Osteoclasts, Increase Osteoclastogenesis and Cause Trabecular Bone Loss in Mice.International journal of molecular sciences · 2021Article
- Radiation induces primary osteocyte senescence phenotype and affects osteoclastogenesisInternational journal of molecular medicine · 2021Article
- 0.5‑Gy X‑ray irradiation induces reorganization of cytoskeleton and differentiation of osteoblasts.Molecular medicine reports · 2021Article
- Influence of hyperbaric oxygen therapy on bone metabolism in patients with neoplasm.Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology · 2021Article
- Postradiation Fractures after Combined Modality Treatment in Extremity Soft Tissue Sarcomas.Sarcoma · 2021Review
- The Influence of Radiation on Bone and Bone Cells-Differential Effects on Osteoclasts and Osteoblasts.International journal of molecular sciences · 2020Review
- Review
- Effects of ionizing radiation on woven bone: influence on the osteocyte lacunar network, collagen maturation, and microarchitecture.Clinical oral investigations · 2020Article
- Radium-223 mechanism of action: implications for use in treatment combinations.Nature reviews. Urology · 2019Review
- Evaluation of longitudinal time-lapsed in vivo micro-CT for monitoring fracture healing in mouse femur defect models.Scientific reports · 2019Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Radiation-induced bone loss is a potential health concern for cancer patients undergoing radiotherapy. Enhanced bone resorption by osteoclasts and decreased bone formation by osteoblasts were thought to be the main reasons. In this study, we showed that both pre-differentiating and differentiating osteoclasts were relatively sensitive to X-rays compared with osteoblasts. X-rays decreased cell viability to a greater degree in RAW264.7 cells and in differentiating cells than than in osteoblastic MC3T3-E1 cells. X-rays at up to 8 Gy had little effects on osteoblast mineralization. In contrast, X-rays at 1 Gy induced enhanced osteoclastogenesis by enhanced cell fusion, but had no effects on bone resorption. A higher dose of X-rays at 8 Gy, however, had an inhibitory effect on bone resorption. In addition, actin ring formation was disrupted by 8 Gy of X-rays and reorganized into clusters. An increased activity of Caspase 3 was found after X-ray exposure. Actin disorganization and increased apoptosis may be the potential effects of X-rays at high doses, by inhibiting osteoclast differentiation. Taken together, our data indicate high radiosensitivity of osteoclasts. X-ray irradiation at relatively low doses can activate osteoclastogenesis, but not osteogenic differentiation. The radiosensitive osteoclasts are the potentially responsive cells for X-ray-induced bone loss.
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Registered trials
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