ArticleToxicological sciences : an official journal of the Society of Toxicology2017
Respiratory Effects and Systemic Stress Response Following Acute Acrolein Inhalation in Rats.
Article in Toxicological sciences : an official journal of the Society of Toxicology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 41 citations in OpenAlex.
- Estrogen and glucocorticoid receptors co-regulate acrolein-induced respiratory and systemic homeostatic stress responses.Toxicological sciences : an official journal of the Society of Toxicology · 2025Article
- Adrenergic receptor subtypes differentially influence acrolein-induced ventilatory, vascular leakage, and inflammatory responses.Toxicology and applied pharmacology · 2025Article
- Neuroendocrine contribution to sex-related variations in adverse air pollution health effects.Journal of toxicology and environmental health. Part B, Critical reviews · 2024Review
- Countermeasures against Pulmonary Threat Agents.The Journal of pharmacology and experimental therapeutics · 2024Review
- Serum metabolome and liver transcriptome reveal acrolein inhalation-induced sex-specific homeostatic dysfunction.Scientific reports · 2023Article
- Multimodal Diagnostics of Changes in Rat Lungs after Vaping.Diagnostics (Basel, Switzerland) · 2023Article
- Sex-specific respiratory and systemic endocrine effects of acute acrolein and trichloroethylene inhalation.Toxicology letters · 2023Article
- Differential Cardiopulmonary Effects of Isoprene- versus Toluene-generated Photochemically-Aged Smog in Rats.Atmospheric environment (Oxford, England : 1994) · 2023Article
- Differential transcriptomic alterations in nasal versus lung tissue of acrolein-exposed rats.Frontiers in toxicology · 2023Article
- Stress Drivers of Glucose Dynamics during Ozone Exposure Measured Using Radiotelemetry in Rats.Environmental health perspectives · 2022Article
- Acrolein inhalation acutely affects the regulation of mitochondrial metabolism in rat lung.Toxicology · 2022Article
- Adrenergic and Glucocorticoid Receptors in the Pulmonary Health Effects of Air Pollution.Toxics · 2021Review
- The Role of Hepatic Vagal Tone in Ozone-Induced Metabolic Dysfunction in the Liver.Toxicological sciences : an official journal of the Society of Toxicology · 2021Article
- Exposure to volatile organic compounds - acrolein, 1,3-butadiene, and crotonaldehyde - is associated with vascular dysfunction.Environmental research · 2021Article
- Pulmonary and vascular effects of acute ozone exposure in diabetic rats fed an atherogenic diet.Toxicology and applied pharmacology · 2021Article
- Peripheral metabolic effects of ozone exposure in healthy and diabetic rats on normal or high-cholesterol diet.Toxicology and applied pharmacology · 2021Article
- The Impacts of Illegal Toxic Waste Dumping on Children's Health: A Review and Case Study from Pasir Gudang, Malaysia.International journal of environmental research and public health · 2021Review
- Offspring susceptibility to metabolic alterations due to maternal high-fat diet and the impact of inhaled ozone used as a stressor.Scientific reports · 2020Article
- Oleic acid and derivatives affect human endothelial cell mitochondrial function and vasoactive mediator production.Lipids in health and disease · 2020Article
- Susceptibility Variations in Air Pollution Health Effects: Incorporating Neuroendocrine Activation.Toxicologic pathology · 2019Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
Previous studies have demonstrated that exposure to the pulmonary irritant ozone causes myriad systemic metabolic and pulmonary effects attributed to sympathetic and hypothalamus-pituitary-adrenal (HPA) axis activation, which are exacerbated in metabolically impaired models. We examined respiratory and systemic effects following exposure to a sensory irritant acrolein to elucidate the systemic and pulmonary consequences in healthy and diabetic rat models. Male Wistar and Goto Kakizaki (GK) rats, a nonobese type II diabetic Wistar-derived model, were exposed by inhalation to 0, 2, or 4 ppm acrolein, 4 h/d for 1 or 2 days. Exposure at 4 ppm significantly increased pulmonary and nasal inflammation in both strains with vascular protein leakage occurring only in the nose. Acrolein exposure (4 ppm) also caused metabolic impairment by inducing hyperglycemia and glucose intolerance (GK > Wistar). Serum total cholesterol (GKs only), low-density lipoprotein (LDL) cholesterol (both strains), and free fatty acids (GK > Wistar) levels increased; however, no acrolein-induced changes were noted in branched-chain amino acid or insulin levels. These responses corresponded with a significant increase in corticosterone and modest but insignificant increases in adrenaline in both strains, suggesting activation of the HPA axis. Collectively, these data demonstrate that acrolein exposure has a profound effect on nasal and pulmonary inflammation, as well as glucose and lipid metabolism, with the systemic effects exacerbated in the metabolically impaired GKs. These results are similar to ozone-induced responses with the exception of lung protein leakage and ability to alter branched-chain amino acid and insulin levels, suggesting some differences in neuroendocrine regulation of these two air pollutants.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.