Evidence map›Paper›PMID 28541469›Full record

ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2017

Clinical and Molecular Evidence of Atovaquone and Azithromycin Resistance in Relapsed Babesia microti Infection Associated With Rituximab and Chronic Lymphocytic Leukemia.

Matthew S Simon, Lars F Westblade, Alexis Dziedziech, Joseph E Visone, Richard R Furman, Stephen G Jenkins, Audrey N Schuetz, Laura A Kirkman

Open access · bronzeAbstract readCase Reports
In one paragraph

Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed
3.4field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 84 citations in OpenAlex.

  1. Article
  2. Review
  3. Evaluating acridones as novel therapeutics for human babesiosis.Antimicrobial agents and chemotherapy · 2026
    Article
  4. Tafenoquine: A Breakthrough Option for Babesiosis Treatment.Tropical medicine and infectious disease · 2026
    Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Antimicrobial agents and chemotherapy · 2024
    Article
  13. Tafenoquine for Relapsing Babesiosis: A Case Series.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2024
    Article
  14. Article
  15. Article
  16. Transfusion-transmittedJournal of clinical microbiology · 2023
    Review
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Matthew S SimonDepartment of Medicine, Division of Infectious Diseases.
Lars F WestbladeDepartment of Pathology and Laboratory Medicine.
Alexis DziedziechDepartment of Medicine, Division of Infectious Diseases.
Joseph E VisoneDepartment of Microbiology and Immunology, and.
Richard R FurmanDepartment of Medicine, Division of Hematology Oncology, Weill Cornell Medicine,New York, New York; and.
Stephen G JenkinsDepartment of Pathology and Laboratory Medicine.
Audrey N SchuetzMayo Clinic, Department of Laboratory Medicine and Pathology, Rochester, Minnesota.
Laura A KirkmanDepartment of Medicine, Division of Infectious Diseases.
Office of Infectious Diseases · USMayo Clinic · USWeill Cornell Medicine · US

Funding

Clinical and Translational Science CenterUL1TR000457 · NCATS · WEILL MEDICAL COLL OF CORNELL UNIV · PI IMPERATO-MCGINLEY, JULIANNE L · 2012 to 2016
$46.0M
NCATS NIH HHS UL1 TR000457
6 · The paper itself

Abstract

Babesiosis treatment failures with standard therapy have been reported, but the molecular mechanisms are not well understood. We describe the emergence of atovaquone and azithromycin resistance associated with mutations in the binding regions of the target proteins of both drugs during treatment of an immunosuppressed patient with relapsing babesiosis.

Indexed as

Aged, 80 and overAmino Acid SequenceAntiprotozoal AgentsAtovaquoneAzithromycinBabesia microtiBabesiosisDrug ResistanceHumansLeukemia, Lymphocytic, Chronic, B-CellMaleRituximabAntiprotozoal AgentsAtovaquoneAzithromycinRituximab

Identifiers

PMID28541469
PMCPMC6248624
OpenAlexW2618278720

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.