Observational studyAge and ageing2017
Grip strength and inflammatory biomarker profiles in very old adults.
Observational study in Age and ageing, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- Factors associated with handgrip strength across the life course: A systematic review.Journal of cachexia, sarcopenia and muscle · 2024Pooled it
- Joint associations of grip strength, lipid levels, and lipid-related genetic risk with atrial fibrillation.Lipids in health and disease · 2026Article
- Genetically Predicted Homocysteine Levels and B Vitamins on Sarcopenia-Related Traits: Insights From an Observational and Mendelian Randomization Analysis.Food science & nutrition · 2026Article
- Systemic inflammation is associated with reduced functional recovery in older inpatients with chronic kidney disease.International urology and nephrology · 2026Observational
- Elevated Inflammatory Burden Index Is Association With Increased Sarcopenia: A Population-Based Study.Mediators of inflammation · 2026Article
- Joint associations of handgrip strength and functional disability with cognitive impairment in older adults.European journal of medical research · 2025Article
- Abnormal maximal tubular reabsorption of phosphate as a novel biomarker of physical dysfunction in older adults.Aging clinical and experimental research · 2025Article
- Age Difference in the Association Between Nutritional Status and Dynapenia in Older Adults.Nutrients · 2025Article
- Exploring the relationship between grip strength and diabetic nephropathy among U.S. adults with type 2 diabetes mellitus: a cross-sectional NHANES analysis.BMC endocrine disorders · 2025Article
- Article
- Association between combined urinary phthalate metabolites exposure and grip strength among residents in Guangzhou, China.Frontiers in public health · 2025Article
- Bridging Pain and Motoric Cognitive Risk Syndrome: Mediating Effect of Handgrip Strength.Journal of pain research · 2025Article
- Grip strength predicts postoperative ileus among patients undergoing abdominal minimally invasive surgery: a prospective multicenter cohort study.Surgical endoscopy · 2024Article
- Evaluation of Sarcopenia by Psoas Muscle Measurements in Bullous Pemphigoid: A Single-Institution Survey in Japan.Cureus · 2024Article
- Association of grip strength, sleep duration, and comorbidities with depressive symptoms in middle-aged and older patients with chronic lung diseases: a cross-sectional network analysis based on CHARLS data.Frontiers in psychology · 2024Article
- Diagnostics of inflammaging in relation to sarcopenia.Frontiers in public health · 2023Article
- Bidirectional association between handgrip strength and ADLs disability: a prospective cohort study.Frontiers in public health · 2023Article
- Influences of Vitamin D and Iron Status on Skeletal Muscle Health: A Narrative Review.Nutrients · 2022Review
- Causal effects of homocysteine levels on the components of sarcopenia: A two-sample mendelian randomization study.Frontiers in genetics · 2022Article
- Impact of intramuscular adipose tissue content on short- and long-term outcomes of hepatectomy for colorectal liver metastasis: a retrospective analysis.World journal of surgical oncology · 2020Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
Background: weak grip strength (GS) and chronic inflammation have been implicated in the aetiology of sarcopenia in older adults. Given the interrelationships between inflammatory biomarkers, a summary variable may provide better insight into the relationship between inflammation and muscle strength. This approach has not been investigated in very old adults (aged ≥85) who are at highest risk of muscle weakness. Methods: we used mixed models to explore the prospective association between GS over 5 years in 845 participants in the Newcastle 85+ Study, and inflammatory components identified by principal component analysis (PCA). Cut-offs of ≤27 kg (men) and ≤16 (women) were used to define sub-cohorts with weak and normal GS at each assessment. Results: PCA identified three components, which explained 70% of the total variance in seven baseline biomarkers. Basal interleukin-6 (IL-6) and tumour necrosis factor (TNF-α) had the highest loadings on Component 1; stimulated IL-6 and TNF-α and homocysteine the highest on Component 2; high-sensitivity C-reactive protein (hsCRP) loaded positively and albumin negatively to Component 3. In adjusted mixed models, only Component 3 was associated with GS. One SD increase of Component 3 was associated with a 0.41 kg lower GS initially (P = 0.03) in all participants, but not with GS decline over time. Similar conclusions held for those in the weak and normal GS sub-cohorts. Conclusion: an inflammatory profile including hsCRP and albumin was independently associated with baseline GS. Future studies linking inflammatory profiles and muscle strength are needed to corroborate these findings in older adults.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.