ArticleNature communications2017
Synthesis of spiro quasi[1]catenanes and quasi[1]rotaxanes via a templated backfolding strategy.
Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Covalent Template-Directed Synthesis: A Powerful Tool for the Construction of Complex Molecules.Chemical reviews · 2025Review
- Covalent [2]Catenane and [2]Rotaxane Synthesis via a δ-Amino Acid Template.ACS organic & inorganic Au · 2021Article
- Dynamic covalent self-assembly of mechanically interlocked molecules solely made from peptides.Nature chemistry · 2021Article
- Replication of Sequence Information in Synthetic Oligomers.Accounts of chemical research · 2021Article
- [2]Catenane Synthesis via Covalent Templating.Chemistry (Weinheim an der Bergstrasse, Germany) · 2021Article
- Fluorescent Self-Threaded Peptide Probes for Biological Imaging.Angewandte Chemie (International ed. in English) · 2020Article
- Effect of Thiol Molecular Structure on the Sensitivity of Gold Nanoparticle-Based Chemiresistors toward Carbonyl Compounds.Sensors (Basel, Switzerland) · 2020Article
- Attempting to synthesize lasso peptides using high pressure.PloS one · 2020Article
- Cap control: cyclicRSC advances · 2019Article
- Sequence information transfer using covalent template-directed synthesis.Chemical science · 2019Article
- A heteroditopic macrocycle as organocatalytic nanoreactor for pyrroloacridinone synthesis in water.Beilstein journal of organic chemistry · 2019Article
- A Short Covalent Synthesis of an All-Carbon-Ring [2]Rotaxane.Organic letters · 2017Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Due to their well-defined three-dimensional geometry, spiro compounds are widely utilized in drug research. From the central tetrahedral carbon atom, besides the regular structure, an inverted spiro connectivity may be envisioned. Here we disclose the synthesis of this molecule class that we have coined quasi[1]catenanes. Next to their fascinating and aesthetic shape, the higher compactness as compared to regular spiro bicycles is noteworthy. To enable synthetic access to compact entangled multimacrocyclic molecules, we have developed a new strategy. The key element is a template, which is covalently connected to the linear precursors, and spatially directs the sterically congested backfolding macrocyclizations that are required to give quasi[1]catenanes. Similarly, quasi[1]rotaxanes are made.
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Registered trials
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