ArticleNature communications2017
Coordination of cortical and thalamic activity during non-REM sleep in humans.
Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers.
What it found
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Who cites it
78 citing papers in PubMed, 177 citations in OpenAlex.
- Trial
- Sleep EEG oscillations and synaptic plasticity in memory consolidation across NREM and REM sleep.Dialogues in clinical neuroscience · 2027Review
- Human brain-wide activation of sleep rhythms.eLife · 2026Article
- Thalamic oscillations distinguish natural states of consciousness in humans.Nature human behaviour · 2026Article
- Effects of pulvinar and combined pulvinar/anterior thalamic deep-brain stimulation on sleep: preliminary results.Journal of neurology · 2026Article
- Winding down for the night: changes in thalamocortical connectivity before bed are associated with subsequent sleep-stage duration.Neuroreport · 2026Article
- Fmr1 knockout disrupts multiple intrinsic properties via reduced HCN channel activity in mediodorsal thalamocortical neurons.Experimental physiology · 2026Article
- Article
- SLEEP AND NEURODEGENERATION: EXAMINING POTENTIAL PHYSIOLOGICAL MECHANISMS.Current sleep medicine reports · 2025Article
- Article
- Fast ripple band high-frequency activity associated with thalamic sleep spindles in pediatric epilepsy.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2025Article
- Alterations in White Matter Structure in Sleep-Related Epilepsies: A TBSS-Based Diffusion Tensor Imaging Study.Neuropsychiatric disease and treatment · 2025Article
- Polarity-dependent modulation of sleep oscillations and cortical excitability in aging.Frontiers in aging neuroscience · 2025Article
- Acute Sleep Deprivation Suppresses Sleep Spindles in Mice.Nature and science of sleep · 2025Article
- Selective Modulation of Fear Memory in Non-Rapid Eye Movement Sleep.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Thalamic spindles and Up states coordinate cortical and hippocampal co-ripples in humans.PLoS biology · 2024Article
- Topography of putative bidirectional interaction between hippocampal sharp wave ripples and neocortical slow oscillations.bioRxiv : the preprint server for biology · 2024Article
- The human claustrum tracks slow waves during sleep.Nature communications · 2024Article
- Binding of cortical functional modules by synchronous high-frequency oscillations.Nature human behaviour · 2024Article
- Cross-regional coordination of activity in the human brain during autobiographical self-referential processing.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
18 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
Every night, the human brain produces thousands of downstates and spindles during non-REM sleep. Previous studies indicate that spindles originate thalamically and downstates cortically, loosely grouping spindle occurrence. However, the mechanisms whereby the thalamus and cortex interact in generating these sleep phenomena remain poorly understood. Using bipolar depth recordings, we report here a sequence wherein: (1) convergent cortical downstates lead thalamic downstates; (2) thalamic downstates hyperpolarize thalamic cells, thus triggering spindles; and (3) thalamic spindles are focally projected back to cortex, arriving during the down-to-upstate transition when the cortex replays memories. Thalamic intrinsic currents, therefore, may not be continuously available during non-REM sleep, permitting the cortex to control thalamic spindling by inducing downstates. This archetypical cortico-thalamo-cortical sequence could provide the global physiological context for memory consolidation during non-REM sleep.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.