ReviewNature reviews. Rheumatology2017
Antinuclear antibody testing - misunderstood or misbegotten?
Review in Nature reviews. Rheumatology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 82 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
82 citing papers in PubMed, 2 syntheses or guidelines pooled it, 185 citations in OpenAlex.
- Glucocorticoids Improve the Pregnancy Rate and Outcome in Women With Unexplained Positive Autoantibodies: A Systematic Review and Meta-Analysis.Frontiers in medicine · 2022Pooled it
- A multianalyte assay panel with cell-bound complement activation products demonstrates clinical utility in systemic lupus erythematosus.Lupus science & medicine · 2021Pooled it
- Diagnostic Anchoring on Positive Autoimmune Serologies in Polysymptomatic Patients.Journal of general internal medicine · 2026Article
- Cell-based ELISA using intact HEp-2 cells: an alternative approach for antinuclear antibody detection.Immunologic research · 2026Article
- Beyond the Surface: Antinuclear Antibodies in Rheumatoid Arthritis-Experiences from a Single-Center, Cross-Sectional Observational Study.Antibodies (Basel, Switzerland) · 2026Article
- Antinuclear antibodies seroconversion and endoscopic response to infliximab in biologic-naive Crohn's disease: a Chinese single-center, retrospective study.Intestinal research · 2026Article
- Autoantibody Ordering Patterns Across a Tertiary Hospital: A Retrospective Audit.Open access rheumatology : research and reviews · 2026Article
- A new immunological paradigm for diseases: the protein-homeostasis-system hypothesis.Frontiers in immunology · 2026Review
- Fusion of Generative AI Techniques and Machine Learning Models to Generate and Investigate Biosignals for Glucose Sensors.ACS omega · 2025Article
- Neonatal lupus erythematosus: an acquired autoimmune disease to be taken seriously.Annals of medicine · 2025Review
- Vitamin D as an Immune Modulator in Systemic Lupus Erythematosus: A Narrative Review.Life (Basel, Switzerland) · 2025Review
- A Case Report in Using a Laboratory-Based Decision Support Alert for Research Enrollment and Randomization.Applied clinical informatics · 2025Article
- Warm Autoimmune Hemolytic Anemia Unmasked by Blood Transfusion in a Patient With Prostate Cancer: A Case Report.Cureus · 2025Article
- Anti-Nuclear Antibody Staining Patterns in Juvenile Idiopathic Arthritis: Association of AC-1 Pattern and Elevated Titers with Uveitis.Medeniyet medical journal · 2025Article
- Autoantibodies in Systemic Lupus Erythematosus: Diagnostic and Pathogenic Insights.Journal of clinical medicine · 2025Review
- A presentation of systemic lupus erythematosus manifesting as abdominal pain: a case report.Journal of medical case reports · 2025Article
- Diagnosis of Systemic Rheumatic Disease Using the Connective Tissue Disease Screen.Antibodies (Basel, Switzerland) · 2025Review
- Crystalline silica exposure induces multiple systemic autoimmune phenotypes including inflammatory arthritis and nephritis in Collaborative Cross mice with differing sub-clinical autoimmune profiles.bioRxiv : the preprint server for biology · 2025Article
- Precision Medicine in Rheumatology: The Role of Biomarkers in Diagnosis and Treatment Optimization.Journal of clinical medicine · 2025Review
- Epidemiological Analysis of Antinuclear Antibodies Positivity and Pattern Distribution in a Taiwanese Hospital-Based Cohort.British journal of biomedical science · 2025Article
22 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Antinuclear antibodies (ANAs) are a diverse group of autoantibodies that recognize nuclear macromolecules and their complexes. ANAs represent key biomarkers in the evaluation of rheumatic diseases, most prominently systemic lupus erythematosus (SLE), and ANA testing is commonly performed in the clinical setting. In addition, ANA testing is now used to assess eligibility for participation in clinical trials of new therapeutic agents for SLE. ANAs can be assayed by various techniques, with the fluorescent ANA assay often viewed as the gold standard. Whereas a positive ANA test represents a classification criterion for SLE, up to 20-30% of the healthy population, depending on the assay used, is positive for an ANA, complicating the use of this test for diagnosis or the detection of preclinical autoimmunity. Furthermore, ANAs might be expressed in SLE less commonly than often thought. This Perspectives article discusses important questions about the use of ANA testing in both the clinical and research settings.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.