ArticleNature communications2017
Nonlinear mechanics of hybrid polymer networks that mimic the complex mechanical environment of cells.
Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 86 citations in OpenAlex.
- Decoupling Dynamics and Crosslink Stability in Supramolecular Hydrogels Using Associative Exchange.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Fiber-integrated hydrogels: a versatile platform to improve structural and biological performance in 3D biofabrication.Materials today. Bio · 2026Review
- Fibrous polyisocyanide hydrogels for 3D cell culture applications.Nature protocols · 2025Review
- Magnetically Tunable Hydrogel for Biofilm Control.ACS applied bio materials · 2025Article
- Anisotropic hydrogel microelectrodes for intraspinal neural recordings in vivo.Nature communications · 2025Article
- Mechanical Cell Reprogramming on Tissue-Mimicking Hydrogels for Cancer Cell Transdifferentiation.Research (Washington, D.C.) · 2025Article
- Biomechanics, Energetics, and Structural Basis of Rupture of Fibrin Networks.Advanced healthcare materials · 2023Article
- Repeated Application and Removal of Polyisocyanopeptide Hydrogel Wound Dressings in a Splinted Full-Thickness Wound Model.International journal of molecular sciences · 2023Article
- Regulation of biomaterial implantation-induced fibrin deposition to immunological functions of dendritic cells.Materials today. Bio · 2022Article
- Cell-matrix reciprocity in 3D culture models with nonlinear elasticity.Bioactive materials · 2022Review
- Injectable bottlebrush hydrogels with tissue-mimetic mechanical properties.Science advances · 2022Article
- Tunable Hybrid Matrices Drive Epithelial Morphogenesis and YAP Translocation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Article
- Glycation alters the mechanical behavior of kidney extracellular matrix.Matrix biology plus · 2020Article
- Bottlebrush Bridge between Soft Gels and Firm Tissues.ACS central science · 2020Article
- Influence of Network Topology on the Viscoelastic Properties of Dynamically Crosslinked Hydrogels.Frontiers in chemistry · 2020Article
- Strain shifts under stress-controlled oscillatory shearing in theoretical, experimental, and structural perspectives: Application to probing zero-shear viscosity.Journal of rheology · 2019Article
- Mechanical adaptability of artificial muscles from nanoscale molecular action.Nature communications · 2019Article
- Cytoskeletal stiffening in synthetic hydrogels.Nature communications · 2019Article
- Smart hydrogels with high tunability of stiffness as a biomimetic cell carrier.Cell biology international · 2019Review
- Bond percolation in coloured and multiplex networks.Nature communications · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mechanical properties of cells and the extracellular environment they reside in are governed by a complex interplay of biopolymers. These biopolymers, which possess a wide range of stiffnesses, self-assemble into fibrous composite networks such as the cytoskeleton and extracellular matrix. They interact with each other both physically and chemically to create a highly responsive and adaptive mechanical environment that stiffens when stressed or strained. Here we show that hybrid networks of a synthetic mimic of biological networks and either stiff, flexible and semi-flexible components, even very low concentrations of these added components, strongly affect the network stiffness and/or its strain-responsive character. The stiffness (persistence length) of the second network, its concentration and the interaction between the components are all parameters that can be used to tune the mechanics of the hybrids. The equivalence of these hybrids with biological composites is striking.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.