ArticleIEEE transactions on bio-medical engineering2018
Monitoring Acute Stroke in Mouse Model Using Laser Speckle Imaging-Guided Visible-Light Optical Coherence Tomography.
Article in IEEE transactions on bio-medical engineering, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 33 citations in OpenAlex.
- Maximum fluence for accurate functional photoacoustic microscopy.Photoacoustics · 2026Article
- Visual cortex speckle imaging for shape recognition.Scientific reports · 2025Article
- Visible Light Optical Coherence Tomography: Technology and Biomedical Applications.Bioengineering (Basel, Switzerland) · 2025Review
- Visible-light optical coherence tomography and its applications.Neurophotonics · 2025Review
- Quantitative Optical Imaging of Oxygen in Brain Vasculature.The journal of physical chemistry. B · 2024Review
- Multiscale imaging of corneal endothelium damage and Rho-kinase inhibitor application in mouse models of acute ocular hypertension.Biomedical optics express · 2024Article
- Application of emerging technologies in ischemic stroke: from clinical study to basic research.Frontiers in neurology · 2024Review
- Choosing a polarisation configuration for dynamic light scattering and laser speckle contrast imaging.Biomedical optics express · 2024Article
- Optimizing the precision of laser speckle contrast imaging.Scientific reports · 2023Article
- Temporal alterations in pericytes at the acute phase of ischemia/reperfusion in the mouse brain.Neural regeneration research · 2022Article
- Spatial-Temporal Speckle Variance in the En-Face View as a Contrast for Optical Coherence Tomography Angiography (OCTA).Sensors (Basel, Switzerland) · 2022Article
- Choosing a model for laser speckle contrast imaging.Biomedical optics express · 2021Article
- Combining DC-GAN with ResNet for blood cell image classification.Medical & biological engineering & computing · 2020Article
- Article
- Longitudinal deep-brain imaging in mouse using visible-light optical coherence tomography through chronic microprism cranial window.Biomedical optics express · 2019Article
- Supercontinuum source-based multi-contrast optical coherence tomography for rat retina imaging.Biomedical optics express · 2018Article
- Visible light optical coherence microscopy of the brain with isotropic femtoliter resolution in vivo.Optics letters · 2018Article
- Visible-light optical coherence tomography: a review.Journal of biomedical optics · 2017Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
objectiveMonitoring hemodynamic and vascular changes in the acute stages of mouse stroke models is invaluable in studying ischemic stroke pathophysiology. However, there lacks a tool to simultaneously and dynamically investigate these changes.
methodsWe integrated laser speckle imaging (LSI) and visible-light optical coherence tomography (Vis-OCT) to reveal dynamic vascular responses in acute stages in the distal middle cerebral artery occlusion (dMCAO) model in rodents. LSI provides full-field, real-time imaging to guide Vis-OCT imaging and monitor the dynamic cerebral blood flow (CBF). Vis-OCT offers depth-resolved angiography and oxygen saturation (sO2) measurements.
resultsOur results showed detailed CBF and vasculature changes before, during, and after dMCAO. After dMCAO, we observed insignificant sO2 variation in arteries and arterioles and location-dependent sO2 drop in veins and venules. We observed that higher branch-order veins had larger drops in sO2 at the reperfusion stage after dMCAO.
conclusionThis work suggests that integrated LSI and Vis-OCT is a promising tool for investigating ischemic stroke in mouse models. SIGNIFICANCE: For the first time, LSI and Vis-OCT are integrated to investigate ischemic strokes in rodent models.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.