SynthesisPituitary2017
Pituitary dysfunction in granulomatosis with polyangiitis.
Synthesis in Pituitary, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 40 citations in OpenAlex.
- Microscopic Polyangiitis With Pituitary Dysfunction and Spontaneous Renal Aneurysm Rupture.Journal of medical cases · 2026Article
- Pituitary involvement in ANCA-associated vasculitis: a retrospective single-center experience and literature review.Journal of endocrinological investigation · 2026Article
- Cardiovascular and metabolic outcomes of GH replacement therapy in adults with GH deficiency - gender gaps.Pituitary · 2026Review
- Granulomatosis With Polyangiitis Manifesting With Diabetes Insipidus and Cranial Nerve Involvement: A Case Report and Review of the Literature.Clinical case reports · 2025Article
- Panhypophysitis and infundibulitis associated with granulomatosis with polyangiitis.Endocrinology, diabetes & metabolism case reports · 2025Article
- Pituitary dysfunction with eosinophilic granulomatosis with polyangiitis presenting with diabetes insipidus: a case report and review of the literature.Frontiers in immunology · 2025Review
- Primary angiitis of the CNS and ANCA-associated vasculitis: from pathology to treatment.Rheumatology international · 2024Review
- Clinical characteristics and primary outcomes of patients with ANCA-associated vasculitis and central diabetes insipidus.Frontiers in endocrinology · 2023Review
- Mepolizumab as an effective treatment in a case of hypophysitis in eosinophilic granulomatosis with polyangiitis.Therapeutic advances in neurological disorders · 2023Article
- Granulomatosis with polyangiitis in a patient with polydipsia, facial nerve paralysis, and severe otologic complaints: a case report and review of the literature.Journal of medical case reports · 2022Review
- Diagnostic and Therapeutic Approach in ANCA-Associated Glomerulonephritis: A Review on Management Strategies.Frontiers in medicine · 2022Review
- Granulomatous Polyangiitis With Renal Involvement: A Case Report and Review of Literature.Cureus · 2021Article
- Relapsed granulomatosis with polyangiitis with panhypopituitarism.BMJ case reports · 2021Article
- Ectopic Relapse of Anti-neutrophil Cytoplasmic Antibody-associated Pituitary Vasculitis with No Elevation of Anti-neutrophil Cytoplasmic Antibodies after Renal Remission.Internal medicine (Tokyo, Japan) · 2020Article
- Pituitary dysfunction in granulomatosis with polyangiitis.Clinical rheumatology · 2020Review
- Granulomatosis with Polyangiitis Manifesting as a Symptomatic Sellar Mass in a Young Woman.Cureus · 2019Article
- Non-functioning pituitary adenomas: indications for pituitary surgery and post-surgical management.Pituitary · 2019Review
- Pituitary involvement in patients with granulomatosis with polyangiitis: case series and literature review.Rheumatology international · 2019Review
- Pituitary Involvement in Granulomatosis with Polyangiitis: A Retrospective Analysis in a Single Chinese Hospital and a Literature Review.International journal of endocrinology · 2019Review
- Less known aspects of central hypothyroidism: Part 1 - Acquired etiologies.Journal of clinical & translational endocrinology · 2018Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeGranulomatosis with polyangiitis (GPA) is a multisystem disease, characterized by necrotizing small-vessel vasculitis, which mainly affects the respiratory tract and the kidneys. Pituitary involvement in GPA is rare, present in about 1% of all cases of GPA. To date, only case reports or small case series have been published. Herein we report clinical features, imaging findings, treatment and outcomes in three patients with GPA-related pituitary dysfunction (PD).
methodsA retrospective analysis of three cases of GPA-related PD was conducted, followed by systematic review of the English medical literature using PubMed.
resultsThe three cases include three women aged between 32 and 37 years. PD was the presenting feature in one and two developed PD in the course of the disease. All patients had a pituitary lesion on MRI. Conventional treatment with high doses of glucocorticoids and cyclophosphamide led to resolution or improvement of the MRI abnormalities, whereas it was not effective in restoring PD. A systematic review identified 51 additional patients, showing that GPA can lead to partial or global PD, either at onset or, during the course of the disease. Secondary hypogonadism is the predominant manifestation, followed by diabetes insipidus (DI). Sellar mass with central cystic lesion is the most frequent radiological finding.
conclusionGPA should be carefully considered in patients with a sellar mass and unusual clinical presentation with DI and systemic disease. Although conventional induction-remission treatment improves systemic symptoms and radiological pituitary abnormalities, hormonal deficiencies persist in most of the patients. Therefore, follow-up should include both imaging and pituitary function assessment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.