ReviewDer Unfallchirurg2017
[Osteosynthesis-associated infections : Epidemiology, definition and diagnosis].
Review in Der Unfallchirurg, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 20 citations in OpenAlex.
- Defensive antibacterial coating in orthopaedic surgery: Current evidence and future direction.World journal of orthopedics · 2025Review
- Analysis of risk factors, pathogenic bacteria characteristics, and drug resistance of postoperative surgical site infection in adults with limb fractures.Chinese journal of traumatology = Zhonghua chuang shang za zhi · 2025Article
- Biomaterial-Based Scaffolds as Carriers of Topical Antimicrobials for Bone Infection Prophylaxis.Polish journal of microbiology · 2025Review
- [What should be considered in the case of previous operations or injections prior to hip and knee replacement?]Orthopadie (Heidelberg, Germany) · 2025Review
- Improving the microbiological diagnosis of fracture-related infection and prosthetic joint infection through culturing sonication fluid in Bactec blood culture bottles.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2024Article
- Pathogens in FRI - Do bugs matter? - An analysis of FRI studies to assess your enemy.Journal of orthopaedics · 2024Article
- Bioactive coating provides antimicrobial protection through immunomodulation and phage therapeutics.Materials today. Bio · 2024Review
- INVERSE RELATIONSHIP BETWEEN PLASMA PROTEINS AND SATISFACTORY SURGICAL WOUNDS OUTCOME.Acta ortopedica brasileira · 2023Article
- [50/m-Painful redness and swelling after surgical fracture stabilization : Preparation for the medical specialist examination: part 80].Der Unfallchirurg · 2021Article
- Sonication in the diagnosis of fracture-related infections (FRI)-a retrospective study on 230 retrieved implants.Journal of orthopaedic surgery and research · 2021Article
- [Open reduction and plate/screw osteosynthesis of proximal phalanx fractures].Operative Orthopadie und Traumatologie · 2019Review
- Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Osteosynthesis-associated infections occur in 1-5% after closed and in up to 30% after open fractures. There are three different descriptions of implant-associated infections after fracture fixation, which are crucial for the selection of the adequate treatment strategy; temporal appearance from the index surgery (early versus late), pathogenesis of the infection (exogenous, hematogenous and contiguous from an adjacent focus), duration of infection symptoms (acute versus chronic). Diagnosis of osteosynthesis-associated infection is challenging, as chronic low-grade infections often present only with unspecific and subtle clinical symptoms. History, clinical evaluation, imaging, histopathlogical and microbiological examination build the cornerstones of diagnostics in implant-associated infections. A new onset of rest pain, early loosening of the prosthesis or mechanically unexplained, nonunion should raise suspicion for infection and prompt further evaluation. Percutaneous sinus tracts, purulent wound secretion and skin erosions with visibility of the implant confirm the implant-associated infection. Elevated C‑reactive protein value in blood is a supportive argument for infection, but is neither sensitive nor specific for infection. Imaging plays a key role to detect nonunions, infectious callus, sequester, peri-implant osteolysis and extraosseous and intramedullary involvement. Through microbiological and histopathological examination of intraoperative tissue samples, as well as sonication of explanted implants the causative pathogen is identified in most cases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.