Evidence map›Paper›PMID 28540433›Full record

ArticleEuropean journal of pediatrics2017

Altered tetrahydrobiopterin metabolism in patients with phenylalanine hydroxylase deficiency.

Francesca Nardecchia, Flavia Chiarotti, Claudia Carducci, Silvia Santagata, Giulia Valentini, Antonio Angeloni, Nenad Blau, Vincenzo Leuzzi

Abstract read
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Article in European journal of pediatrics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Francesca NardecchiaDepartment of Pediatrics, Child Neurology and Psychiatry, SAPIENZA University of Rome, Via dei Sabelli 108, 00185, Rome, Italy.
Flavia ChiarottiDepartment of Cell Biology and Neuroscience, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161, Rome, Italy.
Claudia CarducciDepartment of Experimental Medicine, SAPIENZA University of Rome, Viale del Policlinico 155, 00161, Rome, Italy.
Silvia SantagataDepartment of Experimental Medicine, SAPIENZA University of Rome, Viale del Policlinico 155, 00161, Rome, Italy.
Giulia ValentiniDepartment of Pediatrics, Child Neurology and Psychiatry, SAPIENZA University of Rome, Via dei Sabelli 108, 00185, Rome, Italy.
Antonio AngeloniDepartment of Experimental Medicine, SAPIENZA University of Rome, Viale del Policlinico 155, 00161, Rome, Italy.
Nenad BlauDietmar-Hopp-Metabolic Center, University Children's Hospital, Heidelberg, Germany.
Vincenzo LeuzziDepartment of Pediatrics, Child Neurology and Psychiatry, SAPIENZA University of Rome, Via dei Sabelli 108, 00185, Rome, Italy. vincenzo.leuzzi@uniroma1.it.
Policlinico Umberto I · ITSapienza University of Rome · ITHeidelberg University · DEIstituto Superiore di Sanità · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The tetrahydrobiopterin (BH

conclusionCommon metabolic (blood Phe levels) and individual (age) factors implicated in the assessment of PKU outcome account only marginally and transiently for the variability of neopterin and biopterin excretion in PKU patients. Other unknown homeostatic factors may probably affect the individual response to chronically elevated Phe levels. What is Known: • In PKU patients, a high urinary excretion of biopterin and neopterin is found. • Biopterin and neopterin excretion is influenced by age and phenylalanine levels. W hat is New: • Blood phenylalanine concentration is the major determinant on pterin excretion in PKU patients in the first months of life. • In older PKU patients, the influence of phenylalanine on pterin excretion is less prominent.

Indexed as

AdolescentAdultBiomarkersBiopterinsCase-Control StudiesChildChild, PreschoolFemaleHumansInfantInfant, NewbornLongitudinal StudiesMaleMultivariate AnalysisNeopterinPhenylalanineBiomarkersBiopterinsNeopterinPhenylalaninesapropterinTyrosineBiochemical variability in PKUBiopterinNeopterinPhenylketonuriaTetrahydrobiopterin (BH4)

Identifiers

PMID28540433
OpenAlexW2619206461

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.