ReviewNeuroradiology2017
Imaging of cerebral ischemic edema and neuronal death.
Review in Neuroradiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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The trial behind it
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Who cites it
44 citing papers in PubMed.
- Intravenous Glibenclamide Reduces Lesional Water Uptake in Large Hemispheric Infarction.Stroke · 2019Trial
- Effect of IV alteplase on the ischemic brain lesion at 24-48 hours after ischemic stroke.Neurology · 2018Trial
- Carrier-Free Rapamycin-Loaded Nanoparticles with MRI and Near-Infrared Fluorescence Bimodal Imaging for Precise Diagnosis and Synergistic Therapy of Ischemic Stroke.International journal of nanomedicine · 2026Article
- The independent prognostic value of brain diffusion tensor imaging in comatose patients after cardiac arrest.Brain informatics · 2025Article
- Simultaneous MRI and laser Doppler Flowmetry: Assessing cerebral Macro- and microcirculation in neurointensive care.NeuroImage. Clinical · 2025Article
- Recanalization status and temporal evolution of early ischemic changes following stroke thrombectomy.European stroke journal · 2024Article
- Target-based deep learning network surveillance of non-contrast computed tomography for small infarct core of acute ischemic stroke.Frontiers in neurology · 2024Article
- Distinct Alterations in Oxygenation, Ion Composition and Acid-Base Balance in Cerebral Collaterals During Large-Vessel Occlusion Stroke.Clinical neuroradiology · 2023Observational
- Semiautomated Detection of Early Infarct Signs on Noncontrast CT Improves Interrater Agreement.Stroke · 2023Article
- Improved Visualization and Quantification of Net Water Uptake in Recent Small Subcortical Infarcts in the Thalamus Using Computed Tomography.Diagnostics (Basel, Switzerland) · 2023Article
- Multinuclear MRI Reveals Early Efficacy of Stem Cell Therapy in Stroke.Translational stroke research · 2023Article
- Free water corrected diffusion tensor imaging discriminates between good and poor outcomes of comatose patients after cardiac arrest.European radiology · 2023Article
- Assessing Brain Tissue Viability on Nonenhanced Computed Tomography After Ischemic Stroke.Stroke · 2023Article
- Cerebral monitoring in a pig model of cardiac arrest with 48 h of intensive care.Intensive care medicine experimental · 2022Article
- Automated quantitative lesion water uptake in acute stroke is a predictor of malignant cerebral edema.European radiology · 2022Article
- Detecting brain lesions in suspected acute ischemic stroke with CT-based synthetic MRI using generative adversarial networks.Annals of translational medicine · 2022Article
- Normal Appearing Ischaemic Brain Tissue on CT and Outcome After Intravenous Alteplase.Frontiers in radiology · 2022Article
- Molecular, Pathological, Clinical, and Therapeutic Aspects of Perihematomal Edema in Different Stages of Intracerebral Hemorrhage.Oxidative medicine and cellular longevity · 2022Review
- Accuracy of thin-slice model-based iterative reconstruction designed for brain CT to diagnose acute ischemic stroke in the middle cerebral artery territory: a multicenter study.Neuroradiology · 2021Article
- Cytotoxic Lesion in the Splenium of Corpus Callosum Secondary to Subacute Methotrexate Neurotoxicity.Avicenna journal of medicine · 2021Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeIn acute cerebral ischemia, the assessment of irreversible injury is crucial for treatment decisions and the patient's prognosis. There is still uncertainty how imaging can safely differentiate reversible from irreversible ischemic brain tissue in the acute phase of stroke.
methodsWe have searched PubMed and Google Scholar for experimental and clinical papers describing the pathology and pathophysiology of cerebral ischemia under controlled conditions.
resultsWithin the first 6 h of stroke onset, ischemic cell injury is subtle and hard to recognize under the microscope. Functional impairment is obvious, but can be induced by ischemic blood flow allowing recovery with flow restoration. The critical cerebral blood flow (CBF) threshold for irreversible injury is ~15 ml/100 g × min. Below this threshold, ischemic brain tissue takes up water in case of any residual capillary flow (ionic edema). Because tissue water content is linearly related to X-ray attenuation, computed tomography (CT) can detect and measure ionic edema and, thus, determine ischemic brain infarction. In contrast, diffusion-weighted magnetic resonance imaging (DWI) detects cytotoxic edema that develops at higher thresholds of ischemic CBF and is thus highly sensitive for milder levels of brain ischemia, but not specific for irreversible brain tissue injury.
conclusionCT and MRI are complimentary in the detection of ischemic stroke pathology and are valuable for treatment decisions.
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