Evidence map›Paper›PMID 28540368›Full record

ArticleJournal of drug abuse2016

Cocaine Use and Liver Disease are Associated with All-Cause Mortality in the Miami Adult Studies in HIV (MASH) Cohort.

Adriana Campa, Sabrina Sales Martinez, Kenneth E Sherman, Joe Pedro Greer, Yinghui Li, Stephanie Garcia, Tiffanie Stewart, Boubakari Ibrahimou, O Dale Williams, Marianna K Baum

Open access · diamondAbstract read
In one paragraph

Article in Journal of drug abuse, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.4field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Adriana CampaFlorida International University, R Stempel College of Public Health and Social Work, Miami, FL, USA.
Sabrina Sales MartinezFlorida International University, R Stempel College of Public Health and Social Work, Miami, FL, USA.
Kenneth E ShermanUniversity of Cincinnati, College of Medicine, Department of Internal Medicine, Cincinnati, Ohio, USA.
Joe Pedro GreerHerbert Wertheim College of Medicine, Florida International University, Miami, FL, USA.
Yinghui LiFlorida International University, R Stempel College of Public Health and Social Work, Miami, FL, USA.
Stephanie GarciaFlorida International University, R Stempel College of Public Health and Social Work, Miami, FL, USA.
Tiffanie StewartFlorida International University, R Stempel College of Public Health and Social Work, Miami, FL, USA.
Boubakari IbrahimouFlorida International University, R Stempel College of Public Health and Social Work, Miami, FL, USA.
O Dale WilliamsFlorida International University, R Stempel College of Public Health and Social Work, Miami, FL, USA.
Marianna K BaumFlorida International University, R Stempel College of Public Health and Social Work, Miami, FL, USA.
Florida International University · USUniversity of Cincinnati Medical Center · US

Funding

Community-Engaged Research on COVID-19 Testing Among Underserved and/or Vulnerable PopulationsU01DA040381 · NIDA · FLORIDA INTERNATIONAL UNIVERSITY · PI BAUM, MARIANNA K · 2015 to 2022
$9.6M
HIV and HIV/HCV-Infection, Disease Progression, Oxidative Stress and AntioxidantsR01DA023405 · NIDA · FLORIDA INTERNATIONAL UNIVERSITY · PI BAUM, MARIANNA K · 2007 to 2011
$2.9M
Alcohol & Antiretrovirals in HIV Infection, Oxidative Stress and Liver DiseaseR01AA018011 · NIAAA · FLORIDA INTERNATIONAL UNIVERSITY · PI BAUM, MARIANNA K · 2008 to 2012
$2.3M
Community-Engaged Research on COVID-19 Testing Among Underserved and/or Vulnerable Populations Phase IIU01MD017423 · NIMHD · FLORIDA INTERNATIONAL UNIVERSITY · PI BAUM, MARIANNA K · 2022 to 2023
$2.2M
NIAAA NIH HHS R01 AA018011NIDA NIH HHS R01 DA023405NIDA NIH HHS U01 DA040381NIMHD NIH HHS U01 MD017423
6 · The paper itself

Abstract

objectiveLiver disease is a frequent cause of morbidity and mortality in HIV infection. We examined the relationship of cocaine use, liver disease progression and mortality in an HIV-infected cohort.

methodsConsent was obtained from 487 HIV+ participants, a subset of the Miami Adult Studies on HIV (MASH) cohort. Participants were eligible if they were followed for at least two years, completed questionnaires on demographics and illicit drug use and had complete metabolic panels, CD4 cell counts and HIV-viral loads. FIB-4 was calculated and cut-off points were used for staging liver fibrosis. Death certificates were obtained.

resultsParticipants were 65% men, 69% Black and 81% were on ART at recruitment. Cocaine was used by 32% of participants and 29% were HIV/HCV co-infected. Mean age was 46.9 ± 7.7 years, mean CD4 cell count was 501.9 ± 346.7 cells/μL and mean viral load was 2.75 ± 1.3 log

conclusionCocaine use and liver fibrosis are strong and independent predictors of mortality in HIV infected and HIV/HCV co-infected adults. Effective interventions to reduce cocaine use among people living with HIV (PHLW) are needed.

Indexed as

CocaineHIVLiver diseaseMortalityOxidative stress

Identifiers

PMID28540368
PMCPMC5439351
OpenAlexW2574717183

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.