ReviewCardiovascular diagnosis and therapy2017
Myocardial flow reserve (MFR) with positron emission tomography (PET)/computed tomography (CT): clinical impact in diagnosis and prognosis.
Review in Cardiovascular diagnosis and therapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it, 73 citations in OpenAlex.
- Comparison of diagnostic accuracy of PET-derived myocardial blood flow parameters: A meta-analysis.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2020Pooled it
- Cardiovascular imaging with total-body PET.The British journal of radiology · 2026Review
- Myocardial flow reserve estimation from standardized uptake values ofAnnals of nuclear medicine · 2026Article
- Multicenter Evaluation of Myocardial Flow Reserve as a Prognostic Marker for Mortality inCirculation. Cardiovascular imaging · 2026Article
- Dynamic frame-by-frame motion correction forEuropean journal of nuclear medicine and molecular imaging · 2026Article
- Clinical impact of increasing ratio fromHeart and vessels · 2026Article
- Synergistic Effects of Type D ("Distressed") Personality Traits on Coronary Microvascular Function in Male Physicians With Occupational Burnout: A Cross-Sectional Study.Journal of the American Heart Association · 2025Article
- Noise-aware dynamic image denoising and positron range correction for Rubidium-82 cardiac PET imaging via self-supervision.Medical image analysis · 2025Article
- Heart failure and microvascular dysfunction: an in-depth review of mechanisms, diagnostic strategies, and innovative therapies.Annals of medicine and surgery (2012) · 2025Review
- Visually assessed ischemia on cardiac magnetic resonance, but not quantitative perfusion metrics, predicts symptomatic improvement in coronary artery bypass.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2025Article
- Impact on cardiovascular outcome of coronary revascularization-induced changes in ischemic perfusion defect and myocardial flow reserve.European journal of nuclear medicine and molecular imaging · 2024Article
- Coronary microvascular function in male physicians with burnout and job stress: an observational study.BMC medicine · 2023Observational
- Prognostic value of myocardial flow reserve measured with CZT cardiac-dedicated SPECT low-dose dynamic myocardial perfusion imaging in patients with INOCA.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- The Role of Cardiac PET in Diagnosis and Prognosis of Ischemic Heart Disease: Optimal Modality Across Different Patient Populations.Current atherosclerosis reports · 2023Review
- Association between CZT‑SPECT myocardial blood flow and coronary stenosis: A cross‑sectional study.Experimental and therapeutic medicine · 2023Article
- Home-Based Exercise Training in the Recovery of Multisystem Inflammatory Syndrome in Children: A Case Series Study.Children (Basel, Switzerland) · 2023Article
- Relationships between indicators of prothrombotic activity and coronary microvascular dysfunction in patients with myocardial infarction with obstructive and non-obstructive coronary artery disease.BMC cardiovascular disorders · 2022Article
- An obscure myocardial blood flow may illuminate post-acute sequelae of COVID-19 cardiovascular syndrome.European journal of clinical investigation · 2022Article
- Diagnostic value of regional myocardial flow reserve measurements using Rubidium-82 PET : Disclosures none.The international journal of cardiovascular imaging · 2022Article
- A Multimodality Myocardial Perfusion Phantom: Initial Quantitative Imaging Results.Bioengineering (Basel, Switzerland) · 2022Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In recent years, radionuclide myocardial perfusion imaging (MPI) using positron emission tomography/computed tomography (PET/CT) has emerged as a robust tool for the diagnosis, risk stratification and management of patients with known or established coronary artery disease (CAD). Cardiac PET/CT imaging affords key advantages compared to single photon emission computed tomography (SPECT) that encompass: (I) improved diagnostic accuracy; (II) decreased radiation exposure due to the utilization of short-lived radiopharmaceuticals, and importantly; (III) the ability to quantify noninvasively myocardial blood flow (MBF) in absolute terms, that is in ml per minute per gram of tissue. Quantitative approaches that measure MBF with PET can facilitate the diagnosis of multivessel CAD and offer the opportunity to monitor responses to lifestyle and/or risk factor modification and to therapeutic interventions. The aim of this review is to focus on the potential clinical utility of MBF and will discuss: (I) basics aspects of PET clinical perfusion tracers and flow quantification parameters; (II) limitations of relative MPI, (III) summarize a classification of diseases where flow quantification may be of use; (IV) specifically, review data on the diagnosis and prognostic value of flow quantification.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.