ArticleCureus2017
Association Between Coronary Artery Disease and MicroRNA: Literature Review and Clinical Perspective.
Article in Cureus, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 24 citations in OpenAlex.
- A Plasma Extracellular Vesicle-Derived microRNA Signature as a Potential Biomarker for Subclinical Coronary Atherosclerosis.International journal of molecular sciences · 2025Article
- Platelet miRNAs: differential expression in coronary artery disease and associations with course of left ventricular systolic function.BMC cardiovascular disorders · 2023Article
- Upregulated circulating mir-424 and its' diagnostic value for gram-negative bacteremia after thoracic transplantation.Non-coding RNA research · 2022Article
- miRNA-146a and miRNA-126 as Potential Biomarkers in Patients with Coronary Artery Disease and Generalized Periodontitis.Materials (Basel, Switzerland) · 2021Article
- Association between miR-146a and Tumor Necrosis Factor Alpha (TNF-α) in Stable Coronary Artery Disease.Medicina (Kaunas, Lithuania) · 2021Article
- Hsa-miR-584-5p as a novel candidate biomarker in Turkish men with severe coronary artery disease.Molecular biology reports · 2020Article
- lncRNA-SNHG14 Promotes Atherosclerosis by Regulating RORComputational and mathematical methods in medicine · 2020Article
- Circulating miR-130 and its target PPAR-γ may be potential biomarkers in patients of coronary artery disease with type 2 diabetes mellitus.Molecular genetics & genomic medicine · 2019Article
- Genetic Risk, Adherence to a Healthy Lifestyle, and Ischemic Heart Disease.Current cardiology reports · 2019Review
- Circulating microRNA profiles in different arterial territories of stable atherosclerotic disease: a systematic review.American journal of cardiovascular disease · 2018Review
- Integrating Genes Affecting Coronary Artery Disease in Functional Networks by Multi-OMICs Approach.Frontiers in cardiovascular medicine · 2018Review
- MicroRNAs as monitoring markers for right-sided heart failure and congestive hepatopathy.Journal of medicine and lifeReview
- Dynamics of Soluble Thrombomodulin and Circulating miRNAs in Patients with Atrial Fibrillation Undergoing Radiofrequency Catheter Ablation.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/HemostasisArticle
Corrections and comments
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Authors and funding
15 authors at 9 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundUntil recently, circulating micro-RNAs (miRNAs) have attracted major interest as novel biomarkers for the early diagnosis of coronary artery disease (CAD). This review article summarizes the available evidence on the correlation of micro-RNAs with both the clinical and subclinical coronary artery disease and highlights the necessity for exploring miRNAs as a potential diagnostic and prognostic biomarker of early CAD in an adult population.
methodsA systematic literature analysis and retrieval online systems Public/Publisher MEDLINE/ Excerpta Medica Database /Medical Literature Analysis and Retrieval System Online,(PUBMED/EMBASE/MEDLINE) search were conducted for relevant information. Search was limited to the articles published in English language and conducted on humans, January 2000 onwards. We excluded studies of heart surgery, coronary artery bypass grafting (CABG), angioplasty and heart transplant. Eighteen studies met the inclusion criteria.
resultsSeven out of 18 studies were multivariate, i.e. adjusted for age, gender, body mass index (BMI), smoking, hypertension, diabetes, and blood lipid profiles, while the remaining twelve studies were univariate analysis. Different sources of miRNAs were used, i.e. plasma/serum, microparticles, whole blood, platelets, blood mononuclear intimal and endothelial progenitor cells were investigated. Fourteen out of 18 studies showed up-regulation of different miRNA in CAD patients and in vulnerable plaque disease. Four out of 18 studies showed both the up-regulation and down-regulation of miRNA in the population, while only three studies showed down-regulation of miRNA. Various sources and types of miRNA were used in each study.
conclusionThis review gives an extensive overview of up-regulation and down-regulation of miRNA in CAD and non-CAD patients. The pattern of miRNA regulation with respect to CAD/non-CAD study subjects varies across individual studies and different parameters, which could be the possible reason for this aberrancy. We suggest further trials be conducted in future for highlighting the role of miRNA in CAD, which may improve both the diagnostic and therapeutic approaches to stratifying CAD burden in the general population.
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Registered trials
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