ArticleActa radiologica open2017
Frequency and locations of systemic metastases in Merkel cell carcinoma by imaging.
Article in Acta radiologica open, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
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Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 61 citations in OpenAlex.
- Merkel Cell Carcinoma, Version 1.2018, NCCN Clinical Practice Guidelines in Oncology.Journal of the National Comprehensive Cancer Network : JNCCN · 2018Guideline
- Case report of metastatic Merkel cell carcinoma presenting as purpuric chest discoloration.JAAD case reports · 2026Article
- Diagnosis and treatment of Merkel cell carcinoma in a puppy: A comparative oncology approach.The Canadian veterinary journal = La revue veterinaire canadienne · 2026Article
- Rapidly Progressive Merkel Cell Carcinoma with Atypical Metastatic Pattern-A Case Report and Brief Literature Review.Diagnostics (Basel, Switzerland) · 2025Article
- Distant Metastasis of Merkel Cell Carcinoma: A Descriptive Study.Dermatology practical & conceptual · 2025Article
- Article
- Merkel cell polyomavirus in lung carcinogenesis: evidence and controversy.Frontiers in oncology · 2025Review
- Rubella virus chronic inflammatory disease and other unusual viral phenotypes in inborn errors of immunity.Immunological reviews · 2024Review
- Dermoscopy of skin metastases in advanced cancer-systemic (visceral, hematologic) and cutaneous.Frontiers in medicine · 2024Article
- Large Intestinal Obstruction and Perforation From Metastatic Merkel Cell Carcinoma: A Case Report.Cureus · 2023Article
- An Extraordinary Cause of Colonic Obstruction: Merkel Cell Carcinoma of Unknown Primary.ACG case reports journal · 2023Article
- A rare tonsillar metastasis of Merkel cell carcinoma: A case report.Clinical case reports · 2023Article
- Multimodality imaging findings of infection-induced tumors.Abdominal radiology (New York) · 2022Review
- Review
- Therapeutic Potential of 5'-Methylschweinfurthin G in Merkel Cell Polyomavirus-Positive Merkel Cell Carcinoma.Viruses · 2022Article
- Article
- A case report of 2 patients developing multiple Merkel cell carcinomas-using comparative genomic hybridization to elucidate tumor relationship.JAAD case reports · 2022Article
- Unique presentation of Merkel cell tumour affecting the hand.BMJ case reports · 2022Article
- Demographic features and changing incidence and presentation of Merkel cell carcinoma in a retrospective single-center case series.Archives of dermatological research · 2021Article
- Clinical benefit of baseline imaging in Merkel cell carcinoma: Analysis of 584 patients.Journal of the American Academy of Dermatology · 2021Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe primary neuroendocrine skin cancer, Merkel cell carcinoma (MCC), has a well-known predilection to metastasize systemically. However, the experience of systemic metastases in MCC is mainly disseminated through case reports due to the rarity of MCC. PURPOSE: To elucidate the frequency and locations of systemic metastasis in MCC by reviewing the imaging of patients with metastatic MCC in a national cohort. MATERIAL AND
methodsPatients with diagnosed metastatic MCC by imaging studies in Finland during 1999-2012 were included in this study. We reviewed their imaging studies to evaluate the most frequent sites for systemic metastasis and determined the latency between the primary tumor diagnosis and systemic metastasis. The material includes 30 MCC patients with complete imaging series and 187 examinations, of which 102 (54%) were CT images.
resultsThe mean latency from the primary tumor diagnosis to systemic metastasis was 2.1 years and the mean latency between the radiologic diagnosis of the metastases and death was 299 days. Metastases were recorded in several organ systems in most of the cases, and at least two separate metastatic sites in 63% of the cases. Metastatic spread was noted in 60% of the cases in distant lymph nodes. Liver and lungs were the most affected solid organs.
conclusionSystemic metastasis in MCC has no predilection site, basically every organ system can be involved. Most of the systemic metastases were recorded during the first two years after the MCC diagnosis.
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