ArticleJournal of foot and ankle research2017
Are ultrasound features at the first metatarsophalangeal joint associated with clinically-assessed pain and function? A study of people with gout, asymptomatic hyperuricaemia and normouricaemia.
Article in Journal of foot and ankle research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.
- 2023 EULAR recommendations on imaging in diagnosis and management of crystal-induced arthropathies in clinical practice.Annals of the rheumatic diseases · 2024Guideline
- Physical Impairments in People With Gout: A Scoping Review.Musculoskeletal care · 2025Article
- Gout, Hyperuricemia and Psoriatic Arthritis: An Evolving Conundrum.Current rheumatology reports · 2025Review
- An ultrasonographic study of gouty arthritis: Synovitis and its relationship to clinical symptoms: A retrospective analysis.Health science reports · 2023Article
- Usefulness of ultrasound in the diagnosis of crystal deposition diseases.European journal of rheumatology · 2022Article
- Reliability of knee joint sonography in the evaluation of gouty arthritis.Journal of ultrasonography · 2021Article
- Sonographic estimation of monosodium urate burden predicts the fulfillment of the 2016 remission criteria for gout: a 12-month study.Arthritis research & therapy · 2021Observational
- Performance of Ultrasound in the Clinical Evaluation of Gout and Hyperuricemia.Journal of immunology research · 2021Article
- Risk factors of ultrasound-detected tophi in patients with gout.Clinical rheumatology · 2020Article
Corrections and comments
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Authors and funding
6 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe first metatatarsophalangeal joint (1st MTP joint) is a common location for sonographic evidence of urate deposition in people with gout and asymptomatic hyperuricaemia. However, it is unclear whether these are related to clinically-assessed pain and function. This study aimed to determine the association between ultrasound features and clinical characteristics of the 1st MTP joint in people with gout, asymptomatic hyperuricaemia and age- and sex-matched normouricaemic individuals.
methodsTwenty-three people with gout, 29 with asymptomatic hyperuricaemia and 34 with normouricaemia participated in a cross-sectional study. No participant had clinical evidence of acute inflammatory arthritis at the time of assessment. Four sonographic features at the 1st MTP joint were analysed: double contour sign, tophus, bone erosion and synovitis. Clinical characteristics included in the analysis were 1st MTP joint pain, overall foot pain and disability, 1st MTP joint temperature, 1st MTP joint range of motion and gait velocity. Statistical analyses adjusted for the diagnostic group of the participant.
resultsAfter accounting for the diagnostic group, double contour sign was associated with higher foot pain and disability scores (
conclusionsUltrasound features of urate crystal deposition, rather than soft tissue inflammation or bone erosion, are associated with clinical measures of foot-related functional impairment and disability even in the absence of clinical evidence of current acute inflammatory arthritis. This association persisted regardless of the diagnosis of the participant as having gout or asymptomatic hyperuricaemia.
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