ArticleFrontiers in neurology2017
Herpes Simplex Virus Type 2 Myelitis: Case Report and Review of the Literature.
Article in Frontiers in neurology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Unveiling the clinical spectrum of herpes simplex virus CNS infections in adults: a systematic review.Systematic reviews · 2025Pooled it
- Suspected HSV vs. demyelinating transverse myelitis in patient on TNF alpha inhibitor: a case report.Frontiers in medicine · 2026Article
- Herpetic meningomyelitis: An exceptional presentation of herpes simplex virus.Radiology case reports · 2025Article
- Elsberg syndrome - A systematic review of existing scientific literature from 2000 - 2023.Pakistan journal of medical sciences · 2024Review
- Elsberg Syndrome With Albuminocytologic Dissociation - A Guillain-Barré Syndrome Mimic or Guillain-Barré Syndrome Variant?The Neurohospitalist · 2024Article
- It Looks Like a Spinal Cord Tumor but It Is Not.Cancers · 2024Review
- Article
- Acute transverse myelitis following SARS-CoV-2 vaccination: a case report and review of literature.Journal of neurology · 2022Review
- Neurologic complications of coronavirus and other respiratory viral infections.Handbook of clinical neurology · 2022Review
- Application of metagenomic next-generation sequencing technique for diagnosing a specific case of necrotizing meningoencephalitis caused by human herpesvirus 2.Open life sciences · 2022Article
- Spectrum of Neuroimaging Findings in Post-COVID-19 Vaccination: A Case Series and Review of Literature.Neurology international · 2021Review
- Clinical Challenges in a 49-Year-Old Patient with Severe Tick-Borne Myeloradiculitis Despite Complete Active Vaccination.Vaccines · 2020Article
- Herpes Simplex Virus Type 2 Radiculomyelitis Disguised as Conversion Disorder.Case reports in neurologyArticle
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Non-traumatic myelopathies can result from a wide spectrum of conditions including inflammatory, ischemic, and metabolic disorders. Here, we describe the case of a 60-year old immunocompetent woman who developed acute back pain followed by rapidly ascending flaccid tetraparesis, a C6 sensory level, and sphincter dysfunction within 8 h. Acyclovir and steroids were started on day 2 and herpes simplex virus type 2 (HSV-2) was confirmed by polymerase chain reaction in cerebrospinal fluid. Magnetic resonance imaging revealed a bilateral anterior horn tractopathy expanding from C2 to T2 and cervicothoracic cord swelling. Screening for paraneoplastic antibodies and cancer was negative. Neurophysiology aided in the work-up by corroborating root involvement. Recovery was poor despite early initiation of antiviral treatment, adjuvant anti-inflammatory therapy, and neurorehabilitation efforts. The clinical course, bilateral affection of the anterior horns, and early focal atrophy on follow-up magnetic resonance imaging take a necrotizing myelitis potentially caused by intraneuronal spread of the virus into consideration. Further, we summarize the literature on classical and rare presentations of HSV-2 myeloradiculitis in non-immunocompromised patients and raise awareness for the limited treatment options for a condition with frequent devastating outcome.
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