Evidence map›Paper›PMID 28539853›Full record

ArticleDose-response : a publication of International Hormesis Society

Treatment of Cancer and Inflammation With Low-Dose Ionizing Radiation: Three Case Reports.

Shuji Kojima, Mitsutoshi Tsukimoto, Noriko Shimura, Hironobu Koga, Akishisa Murata, Tsuyoshi Takara

Open access · goldAbstract read
In one paragraph

Article in Dose-response : a publication of International Hormesis Society. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 1 pooled it
4.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Review
  9. Application of Low Doses of Ionizing Radiation in Medical Therapies.Dose-response : a publication of International Hormesis Society
    Article
  10. Effects of Radon From Hot Springs on Lymphocyte Subsets in Peripheral Blood.Dose-response : a publication of International Hormesis Society
    Article
  11. Article
  12. Death of the ALARA Radiation Protection Principle as Used in the Medical Sector.Dose-response : a publication of International Hormesis Society
    Article
  13. Review
  14. Continuous Low-Dose-Rate Irradiation Promotes Growth of Silkworms.Dose-response : a publication of International Hormesis Society
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Evaluation of Brown Micro-Algae Synergies With Low DoseDose-response : a publication of International Hormesis Society
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Shuji KojimaDepartment of Radiation Biosciences, Faculty of Pharmaceutical Sciences, Tokyo University of Science (TUS), Noda-Shi, Chiba, Japan.
Mitsutoshi TsukimotoDepartment of Radiation Biosciences, Faculty of Pharmaceutical Sciences, Tokyo University of Science (TUS), Noda-Shi, Chiba, Japan.
Noriko ShimuraFaculty of Pharmaceutical Sciences, Ohu University, Koriyama, Japan.
Hironobu KogaLead and Company Co, Ltd, Yokohama, Japan.
Akishisa MurataLead and Company Co, Ltd, Yokohama, Japan.
Tsuyoshi TakaraTakara Clinic, Shinagawa-ku, Tokyo, Japan.
Tokyo University of Science · JPOhu University · JPTakara (Japan) · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

There is considerable evidence from experimental studies in animals, as well as from clinical reports, that low-dose radiation hormesis is effective for the treatment of cancer and ulcerative colitis. In this study, we present 3 case reports that support the clinical efficacy of low-dose radiation hormesis in patients with these diseases. First, a patient with prostate cancer who had undergone surgical resection showed a subsequent increase in prostate-specific antigen (PSA). His PSA value started decreasing immediately after the start of repeated low-dose X-ray irradiation treatment and remained low thereafter. Second, a patient with prostate cancer with bone metastasis was treated with repeated low-dose X-ray irradiation. His PSA level decreased to nearly normal within 3 months after starting the treatment and remained at the low level after the end of hormesis treatment. His bone metastasis almost completely disappeared. Third, a patient with ulcerative colitis showed a slow initial response to repeated low-dose irradiation treatment using various modalities, including drinking radon-containing water, but within 8 months, his swelling and bleeding had completely disappeared. After 1 year, the number of bowel movements had become normal. Interest in the use of radiation hormesis in clinical practice is increasing, and we hope that these case reports will encourage further clinical investigations.

Indexed as

cancerclinical trialhormesislow-dose radiationulcerative colitis

Identifiers

PMID28539853
PMCPMC5433552
OpenAlexW2598893565

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.