Evidence map›Paper›PMID 28539658›Full record

ArticleScientific reports2017

Functional compressive mechanics and tissue biocompatibility of an injectable SF/PU hydrogel for nucleus pulposus replacement.

Jingen Hu, Yang Lu, Ling Cai, Kwabena Gyabaah Owusu-Ansah, Gewen Xu, Feilong Han, Junjie Bao, Xiangjin Lin, Yiping Huang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

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  14. Frontiers in bioengineering and biotechnology · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jingen HuDepartment of Orthopedics, the First Affiliated Hospital, School of Medicine, Zhejiang University, NO. 79 Qingchun Road, Hangzhou, Zhejiang, China.
Yang LuDepartment of Orthopedics, the First Affiliated Hospital, School of Medicine, Zhejiang University, NO. 79 Qingchun Road, Hangzhou, Zhejiang, China.ORCID 0000-0002-6474-715X
Ling CaiSchool of Chemistry and Chemical Engineering & the Key Laboratory of Environment-friendly Polymer Materials of Anhui Province, Anhui University, NO. 111 Jiu Long Road, Hefei, China.
Kwabena Gyabaah Owusu-AnsahDepartment of Hepatobilliary and Pancreatic Surgery, the First Affiliated Hospital, School of Medicine, Zhejiang University, NO. 79 Qingchun Road, Hangzhou, Zhejiang, China.
Gewen XuSchool of Chemistry and Chemical Engineering & the Key Laboratory of Environment-friendly Polymer Materials of Anhui Province, Anhui University, NO. 111 Jiu Long Road, Hefei, China.
Feilong HanSchool of Chemistry and Chemical Engineering & the Key Laboratory of Environment-friendly Polymer Materials of Anhui Province, Anhui University, NO. 111 Jiu Long Road, Hefei, China.
Junjie BaoSchool of Chemistry and Chemical Engineering & the Key Laboratory of Environment-friendly Polymer Materials of Anhui Province, Anhui University, NO. 111 Jiu Long Road, Hefei, China.
Xiangjin LinDepartment of Orthopedics, the First Affiliated Hospital, School of Medicine, Zhejiang University, NO. 79 Qingchun Road, Hangzhou, Zhejiang, China. forevertonylu@qq.com.
Yiping HuangSchool of Chemistry and Chemical Engineering & the Key Laboratory of Environment-friendly Polymer Materials of Anhui Province, Anhui University, NO. 111 Jiu Long Road, Hefei, China. 18768115432@sina.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In spinal degenerative disease, an injectable liquid hydrogel can fill in defect entirely, lessen the danger of implant relocation and following loss of disc height, minimizing the operative trauma. Here, we propose an injectable in-situ chemically cross-linked hydrogel by a two-component reaction of liquid silk fibroin with liquid polyurethane at physiological temperature conditions. Confined compression tests and fatigue tests were reported to assess physical properties of the hydrogel. Impact of different diameter on the biomechanical behaviours was tested to evaluate the clinical potentiality of the hydrogel for replacing nucleus pulposus. Degradation behaviours in different solutions and animal experiments were also investigated to examine the tissue biocompatibility of the hydrogel. The hydrogel modulus was affected by the hydrogel geometrical (diameter) parameters. SF/PU composite hydrogel can survive a million cycles, unconstrained fatigue resistance. More importantly, in vivo biocompatibility using New Zealand white rabbits, showed good biocompatibility over a three-month period in culture. Particularly, they showed the significant clinical merit of providing stronger axial compressive stiffness on confined compression test. Based on the outcomes of the present research, the SF/PU composite hydrogel may provide significant advantages for use in future clinical application in replacing nucleus pulposus field.

Indexed as

AnimalsBiomechanical PhenomenaCompressive StrengthFibroinsHydrogelsInjectionsMaleMaterials TestingNucleus PulposusPolyurethanesRabbitsSpinal InjuriesTotal Disc ReplacementWound HealingFibroinsHydrogelsPolyurethanes

Identifiers

PMID28539658
PMCPMC5443820

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.