Evidence map›Paper›PMID 28539646›Full record

Trial reportScientific reports2017

Colonic infusions of short-chain fatty acid mixtures promote energy metabolism in overweight/obese men: a randomized crossover trial.

Emanuel E Canfora, Christina M van der Beek, Johan W E Jocken, Gijs H Goossens, Jens J Holst, Steven W M Olde Damink, Kaatje Lenaerts, Cornelis H C Dejong, Ellen E Blaak

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05354245 (Using a Complex Carbohydrate Mixture Added to a High-protein Diet to Steer Fermentation and Improve Metabolic, Gut and Brain Health), which is not on this map. Cited by 192 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
192citing papers in PubMed, 6 pooled it
13.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05354245 nacompletednot on this mapstarted 2022, after this paper: background citation

Using a Complex Carbohydrate Mixture Added to a High-protein Diet to Steer Fermentation and Improve Metabolic, Gut and Brain Health

TypeinterventionalSponsorMaastricht University Medical CenterRan2022 to 2024Enrolled44ConditionsInsulin Resistance, Impaired Glucose Tolerance, PreDiabetes, Overweight and ObesityArmsFibre supplement (potato-pectin), Placebo, High-protein diet
3 · Its place in the literature

Who cites it

192 citing papers in PubMed, 6 syntheses or guidelines pooled it, 314 citations in OpenAlex.

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  18. Short-chain fatty acids.Nature metabolism · 2026
    Review
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132 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 4 countries.

Emanuel E CanforaDepartment of Human Biology, NUTRIM 'School of Nutrition and Translational Research in Metabolism', Maastricht University Medical Centre, 6229ER, Maastricht, The Netherlands. emanuel.canfora@maastrichtuniversity.nl.
Christina M van der BeekTop Institute Food and Nutrition, 6700AN, Wageningen, The Netherlands.
Johan W E JockenDepartment of Human Biology, NUTRIM 'School of Nutrition and Translational Research in Metabolism', Maastricht University Medical Centre, 6229ER, Maastricht, The Netherlands.
Gijs H GoossensDepartment of Human Biology, NUTRIM 'School of Nutrition and Translational Research in Metabolism', Maastricht University Medical Centre, 6229ER, Maastricht, The Netherlands.
Jens J HolstNNF Center for Basic Metabolic Research, Department of Biomedical Sciences, The Panum Institute, University of Copenhagen, 2200, Copenhagen, Denmark.
Steven W M Olde DaminkDepartment of Surgery, NUTRIM 'School of Nutrition and Translational Research in Metabolism', Maastricht University Medical Centre, 6229ER, Maastricht, The Netherlands.
Kaatje LenaertsTop Institute Food and Nutrition, 6700AN, Wageningen, The Netherlands.
Cornelis H C DejongTop Institute Food and Nutrition, 6700AN, Wageningen, The Netherlands.
Ellen E BlaakDepartment of Human Biology, NUTRIM 'School of Nutrition and Translational Research in Metabolism', Maastricht University Medical Centre, 6229ER, Maastricht, The Netherlands.
Maastricht University Medical Centre · NLTiFN · NLUniversity of Copenhagen · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Short-chain fatty acids (SCFA), formed by microbial fermentation, are believed to be involved in the aetiology of obesity and diabetes. This study investigated the effects of colonic administration of physiologically relevant SCFA mixtures on human substrate and energy metabolism. In this randomized, double-blind, crossover study, twelve normoglycaemic men (BMI 25-35 kg/m

Indexed as

Acetic AcidAdultButyric AcidColonCross-Over StudiesDouble-Blind MethodEnergy MetabolismFastingFatsFatty Acids, VolatileHumansInfusions, ParenteralMaleObesityOverweightOxidation-ReductionAcetic AcidButyric AcidFatsFatty Acids, VolatilePropionatespropionic acid

Identifiers

PMID28539646
PMCPMC5443817
OpenAlexW2614800736

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.