Evidence map›Paper›PMID 28539639›Full record

ArticleScientific reports2017

The Absence of Interferon-β Promotor Stimulator-1 (IPS-1) Predisposes to Bronchiolitis and Asthma-like Pathology in Response to Pneumoviral Infection in Mice.

Jennifer Simpson, Jason P Lynch, Zhixuan Loh, Vivian Zhang, Rhiannon B Werder, Kirsten Spann, Simon Phipps

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Viruses · 2022
    Review
  3. Article
  4. Review
  5. Article
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Jennifer SimpsonSchool of Biomedical Sciences, The University of Queensland, Queensland, 4072, Australia.
Jason P LynchSchool of Biomedical Sciences, The University of Queensland, Queensland, 4072, Australia.ORCID 0000-0003-0889-2616
Zhixuan LohSchool of Biomedical Sciences, The University of Queensland, Queensland, 4072, Australia.
Vivian ZhangSchool of Biomedical Sciences, The University of Queensland, Queensland, 4072, Australia.
Rhiannon B WerderSchool of Biomedical Sciences, The University of Queensland, Queensland, 4072, Australia.
Kirsten SpannSchool of Biomedical Sciences, Queensland University of Technology, 4001, Queensland, Australia.
Simon PhippsSchool of Biomedical Sciences, The University of Queensland, Queensland, 4072, Australia. s.phipps@uq.edu.au.
The University of Queensland · AUTranslational Research Institute · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Respiratory syncytial virus (RSV)-bronchiolitis is a major cause of infant morbidity and mortality and a risk factor for subsequent asthma. We showed previously that toll-like receptor (TLR)7 in plasmacytoid dendritic cells (pDCs) is critical for protection against bronchiolitis and asthma in mice infected with pneumonia virus of mice (PVM), the mouse homolog of RSV. This lack of redundancy was unexpected as interferon-β promotor stimulator-1 (IPS-1) signalling, downstream of RIG-I-like receptor (RLR) and not TLR7 activation, contributes to host defence in hRSV-inoculated adult mice. To further clarify the role of IPS-1 signalling, we inoculated IPS-1

Indexed as

Adaptor Proteins, Signal TransducingAnimalsAsthmaBronchiolitisDEAD Box Protein 58Dendritic CellsHost-Pathogen InteractionsInterferon-alphaMembrane GlycoproteinsMice, Inbred C57BLMice, KnockoutMurine pneumonia virusPneumovirus InfectionsSignal TransductionToll-Like Receptor 7Adaptor Proteins, Signal TransducingDEAD Box Protein 58Interferon-alphaMAVS protein, mouseMembrane GlycoproteinsTlr7 protein, mouseToll-Like Receptor 7

Identifiers

PMID28539639
PMCPMC5443759
OpenAlexW2615098385

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.