ArticleScientific reports2017
Whole blood transcriptome analysis reveals potential competition in metabolic pathways between negative energy balance and response to inflammatory challenge.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Maternal Hydroxytyrosol Supplementation Enhances Antioxidant Capacity and Immunometabolic Adaptations in Nutrient-Restricted Beef Cows and Their Offspring.Antioxidants (Basel, Switzerland) · 2025Article
- What happens when the lights are left on? Transcriptomic and phenotypic habituation to light pollution.iScience · 2024Article
- Integration of multi-omics reveals the important role of the BBS10 gene in reproduction.Journal of animal science · 2024Article
- Milk metabolite profiling of dairy cows as influenced by mastitis.Frontiers in veterinary science · 2024Review
- Comparative evaluation for the globin gene depletion methods for mRNA sequencing using the whole blood-derived total RNAs.BMC genomics · 2020Article
- Th17-related mammary immunity, but not a high systemic Th1 immune response is associated with protection against E. coli mastitis.NPJ vaccines · 2020Article
- Strategies for Feeding Unweaned Dairy Beef Cattle to Improve Their Health.Animals : an open access journal from MDPI · 2020Review
- Mismatch of Glucose Allocation between Different Life Functions in the Transition Period of Dairy Cows.Animals : an open access journal from MDPI · 2020Review
- Whole blood transcriptome analysis in feedlot cattle after 35 days of supplementation with a β1-adrenergic agonist.Journal of applied genetics · 2020Article
- Chicken adaptive response to low energy diet: main role of the hypothalamic lipid metabolism revealed by a phenotypic and multi-tissue transcriptomic approach.BMC genomics · 2019Article
- Mammary Gland Transcriptome and Proteome Modifications by Nutrient Restriction in Early Lactation Holstein Cows Challenged with Intra-Mammary Lipopolysaccharide.International journal of molecular sciences · 2019Article
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Authors and funding
8 authors.
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Abstract
Negative Energy Balance (NEB) is considered to increase susceptibility to mastitis. The objective of this study was to improve our understanding of the underlying mechanisms by comparing transcriptomic profiles following NEB and a concomitant mammary inflammation. Accordingly, we performed RNA-seq analysis of blood cells in energy-restricted ewes and control-diet ewes at four different time points before and after intra mammary challenge with phlogogenic ligands. Blood leucocytes responded to NEB by shutting down lipid-generating processes, including cholesterol and fatty acid synthesis, probably under transcriptional control of SREBF 1. Furthermore, fatty acid oxidation was activated and glucose oxidation and transport inhibited in response to energy restriction. Among the differentially expressed genes (DEGs) in response to energy restriction, 64 genes were also differential in response to the inflammatory challenge. Opposite response included the activation of cholesterol and fatty acid synthesis during the inflammatory challenge. Moreover, activation of glucose oxidation and transport coupled with the increase of plasma glucose concentration in response to the inflammatory stimuli suggested a preferential utilization of glucose as the energy source during this stress. Leucocyte metabolism therefore undergoes strong metabolic changes during an inflammatory challenge, which could be in competition with those induced by energy restriction.
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