Evidence map›Paper›PMID 28539437›Full record

ArticleJournal of virology2017

Spontaneous Mutation at Amino Acid 544 of the Ebola Virus Glycoprotein Potentiates Virus Entry and Selection in Tissue Culture.

John B Ruedas, Jason T Ladner, Chelsea R Ettinger, Suryaram Gummuluru, Gustavo Palacios, John H Connor

Open access · bronzeAbstract read
In one paragraph

Article in Journal of virology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Natural History ofVaccines · 2022
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Ebolaviruses: New roles for old proteins.PLoS neglected tropical diseases · 2018
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

John B RuedasDepartment of Microbiology, Boston University School of Medicine, Boston, Massachusetts, USA jruedas@bu.edu jhconnor@bu.edu.
Jason T LadnerCenter for Genome Sciences, U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, USA.
Chelsea R EttingerDepartment of Microbiology, Boston University School of Medicine, Boston, Massachusetts, USA.
Suryaram GummuluruDepartment of Microbiology, Boston University School of Medicine, Boston, Massachusetts, USA.ORCID http://orcid.org/0000-0002-8606-8481
Gustavo PalaciosCenter for Genome Sciences, U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, USA.
John H ConnorDepartment of Microbiology, Boston University School of Medicine, Boston, Massachusetts, USA jruedas@bu.edu jhconnor@bu.edu.ORCID http://orcid.org/0000-0002-8867-7256
Boston University · USUnited States Army Medical Research Institute of Infectious Diseases · US

Funding

Mechanism of cell-associated HIV-1 transmissionR01AI064099 · NIAID · BOSTON UNIVERSITY MEDICAL CAMPUS · PI GUMMULURU, SURYARAM · 2005 to 2020
$5.9M
Genetic probing of residues involved in ebolavirus glycoprotein entryR21AI135517 · NIAID · BOSTON UNIVERSITY MEDICAL CAMPUS · PI CONNOR, JOHN H · 2018 to 2019
$454k
NIAID NIH HHS R01 AI064099NIAID NIH HHS R21 AI135517
6 · The paper itself

Abstract

Ebolaviruses have a surface glycoprotein (GP

Indexed as

Mutation, MissenseSelection, GeneticVirus InternalizationAdaptation, BiologicalAmino Acid SubstitutionAnimalsCell LineDNA Mutational AnalysisEbolavirusGenome, ViralHumansMutant ProteinsRecombination, GeneticReverse GeneticsSequence Analysis, DNASerial Passageenvelope glycoprotein, Ebola virusMutant ProteinsViral Envelope ProteinsadaptationBundibugyo ebolavirusEbola virusglycoproteinsmembrane fusionmutationSudan ebolavirusTai Forest ebolavirustissue culturetissue culture mutationvirus entry

Identifiers

PMID28539437
PMCPMC5651722
OpenAlexW2619904095

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.