Evidence map›Paper›PMID 28539403›Full record

ArticleMolecular biology of the cell2017

SEC23B is required for pancreatic acinar cell function in adult mice.

Rami Khoriaty, Nancy Vogel, Mark J Hoenerhoff, M Dolors Sans, Guojing Zhu, Lesley Everett, Bradley Nelson, Haritha Durairaj, Brooke McKnight, Bin Zhang and 3 more

Open access · greenAbstract read
In one paragraph

Article in Molecular biology of the cell, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 30 citations in OpenAlex.

  1. Article
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  5. Genetics of hemostasis: from bedside to bench and back again.The Journal of clinical investigation · 2024
    Article
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  7. Review
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  14. Molecular Regulatory Mechanism of Exocytosis in the Salivary Glands.International journal of molecular sciences · 2018
    Review
  15. Functions of the COPII gene paralogs SEC23A and SEC23B are interchangeable in vivo.Proceedings of the National Academy of Sciences of the United States of America · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Rami KhoriatyDepartment of Internal Medicine, University of Michigan, Ann Arbor, MI 48109.
Nancy VogelDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109.
Mark J HoenerhoffIn Vivo Animal Core, Unit for Laboratory Animal Medicine, University of Michigan, Ann Arbor, MI 48109.
M Dolors SansDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109.
Guojing ZhuLife Sciences Institute, University of Michigan, Ann Arbor, MI 48109.
Lesley EverettUniversity of Michigan Medical School, University of Michigan, Ann Arbor, MI 48109.
Bradley NelsonDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109.
Haritha DurairajDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109.
Brooke McKnightCollege of Literature Science and the Arts, University of Michigan, Ann Arbor, MI 48109.
Bin ZhangGenomic Medicine Institute, Cleveland Clinic Lerner Research Institute, Cleveland, OH 44195.
Stephen A ErnstDepartment of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI 48109.
David GinsburgDepartment of Internal Medicine, University of Michigan, Ann Arbor, MI 48109 jawillms@med.umich.edu ginsburg@umich.edu.
John A WilliamsDepartment of Internal Medicine, University of Michigan, Ann Arbor, MI 48109 jawillms@med.umich.edu ginsburg@umich.edu.
University of Michigan · USCleveland Clinic Lerner College of Medicine · USHoward Hughes Medical Institute · US

Funding

XenograftP30CA046592 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Alexey I Nesvizhskii · 1988 to 2026
$178.2M
University of Michigan Center for Gastrointestinal ResearchP30DK034933 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI OMARY, BISHR · 1986 to 2021
$22.5M
TRANSGENIC MODELS FOR THE STUDY OF FACTOR V FUNCTIONP01HL057346 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI GORDON, DAVID · 1997 to 2013
$19.9M
ER-to-Golgi transport of coagulation factors V and VIIIR01HL094505 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI ZHANG, BIN · 2009 to 2022
$5.1M
The Molecular Genetics of HemostasisR35HL135793 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI GINSBURG, DAVID · 2017 to 2023
$4.1M
Calcium and Pancreatic Stimulus-Secretion CouplingR37DK041122 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI WILLIAMS, JOHN A · 2006 to 2015
$3.2M
Molecular Genetic Study of von Willebrand FactorR01HL039693 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI GINSBURG, DAVID · 1989 to 2016
$2.4M
The Evolution of the Mammalian SEC23 Paralogs and the Molecular Pathogenesis of Congenital Dyserythropoietic Anemia type IIK08HL128794 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KHORIATY, RAMI · 2015 to 2019
$812k
NCI NIH HHS P30 CA046592NHLBI NIH HHS K08 HL128794NHLBI NIH HHS P01 HL057346NHLBI NIH HHS R01 HL039693NHLBI NIH HHS R01 HL094505NHLBI NIH HHS R35 HL135793NIDDK NIH HHS P30 DK034933NIDDK NIH HHS R37 DK041122
6 · The paper itself

Abstract

Mice with germline absence of SEC23B die perinatally, exhibiting massive pancreatic degeneration. We generated mice with tamoxifen-inducible, pancreatic acinar cell-specific

Indexed as

Acinar CellsAnimalsApoptosisCell ProliferationEndoplasmic ReticulumEndoplasmic Reticulum StressEpithelial CellsMiceMice, TransgenicPancreasVesicular Transport ProteinsSEC23B protein, mouseVesicular Transport Proteins

Identifiers

PMID28539403
PMCPMC5509426
OpenAlexW2617515716

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.