Evidence map›Paper›PMID 28539382›Full record

ArticleJournal of the American Society of Nephrology : JASN2017

IL233, A Novel IL-2 and IL-33 Hybrid Cytokine, Ameliorates Renal Injury.

Marta E Stremska, Sheethal Jose, Vikram Sabapathy, Liping Huang, Amandeep Bajwa, Gilbert R Kinsey, Poonam R Sharma, Saleh Mohammad, Diane L Rosin, Mark D Okusa and 1 more

Open access · greenAbstract read
In one paragraph

Article in Journal of the American Society of Nephrology : JASN, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed
4.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

63 citing papers in PubMed, 96 citations in OpenAlex.

  1. Review
  2. Review
  3. ST2 Signaling Regulates Innate Immune Responses in Kidney Injury.bioRxiv : the preprint server for biology · 2026
    Article
  4. Review
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Innate Lymphoid Cells Are the Rheostat of Immune Response in the Kidney.Journal of cellular and molecular medicine · 2025
    Review
  11. Review
  12. ST2 + T-Regulatory Cells as a Potential Immunotherapy Target for Kidney Fibrosis.Journal of the American Society of Nephrology : JASN · 2025
    Article
  13. Review
  14. ST2 + T-Regulatory Cells in Renal Inflammation and Fibrosis after Ischemic Kidney Injury.Journal of the American Society of Nephrology : JASN · 2025
    Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article

3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Marta E StremskaDivision of Nephrology and Center for Immunity, Inflammation and Regenerative Medicine, Department of Medicine, and.
Sheethal JoseDivision of Nephrology and Center for Immunity, Inflammation and Regenerative Medicine, Department of Medicine, and.
Vikram SabapathyDivision of Nephrology and Center for Immunity, Inflammation and Regenerative Medicine, Department of Medicine, and.
Liping HuangDivision of Nephrology and Center for Immunity, Inflammation and Regenerative Medicine, Department of Medicine, and.
Amandeep BajwaDivision of Nephrology and Center for Immunity, Inflammation and Regenerative Medicine, Department of Medicine, and.
Gilbert R KinseyDivision of Nephrology and Center for Immunity, Inflammation and Regenerative Medicine, Department of Medicine, and.
Poonam R SharmaBiomedical Engineering, University of Virginia, Charlottesville, Virginia.
Saleh MohammadDivision of Nephrology and Center for Immunity, Inflammation and Regenerative Medicine, Department of Medicine, and.
Diane L RosinDepartments of Pharmacology.
Mark D OkusaDivision of Nephrology and Center for Immunity, Inflammation and Regenerative Medicine, Department of Medicine, and.
Rahul SharmaDivision of Nephrology and Center for Immunity, Inflammation and Regenerative Medicine, Department of Medicine, and rs3wn@virginia.edu.
Laboratoire d’immunologie intégrative du cancer · FRUniversity of Virginia · US

Funding

Women's Oncology Program - WONP30CA044579 · NCI · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI Thomas P. Loughran · 1987 to 2026
$72.1M
Sphingolipids in Acute Kidney Injury and Disease ProgressionR01DK085259 · NIDDK · UNIVERSITY OF VIRGINIA · PI OKUSA, MARK DOUGLAS · 2010 to 2023
$5.0M
Leukocyte Trafficking in Acute Renal FailureR01DK062324 · NIDDK · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI OKUSA, MARK DOUGLAS · 2003 to 2016
$4.4M
Ultrasound for Non-Invasive Prevention of Acute Kidney InjuryR01DK105133 · NIDDK · UNIVERSITY OF VIRGINIA · PI OKUSA, MARK DOUGLAS · 2015 to 2019
$2.4M
The TREX1 Pathway in Autoimmune DiseaseR01AI116725 · NIAID · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI PERRINO, FRED W · 2016 to 2020
$1.9M
Regulatory T Cells in Acute Kidney InjuryR01DK104963 · NIDDK · UNIVERSITY OF VIRGINIA · PI SHARMA, RAHUL · 2016 to 2020
$1.8M
Targeting Treg for Therapy of Lupus GlomerulonephritisR01DK105833 · NIDDK · UNIVERSITY OF VIRGINIA · PI FU, SHU MAN, SHARMA, RAHUL · 2016 to 2019
$1.4M
Regulatory T Cells as a Novel Therapeutic Agent/Target for Acute Kidney InjuryK01DK088967 · NIDDK · UNIVERSITY OF VIRGINIA · PI KINSEY, GILBERT R · 2010 to 2014
$593k
Sphingosine 1 phosphate receptors 1 and 3 as novel targets in transplantationK01DK091444 · NIDDK · UNIVERSITY OF VIRGINIA · PI BAJWA, AMANDEEP · 2012 to 2016
$579k
MBF Bioscience and Zeiss Microscope System for Stereology and Tissue MorphologyS10RR026799 · NCRR · UNIVERSITY OF VIRGINIA · PI OKUSA, MARK DOUGLAS · 2010 to 2010
$278k
NCI NIH HHS P30 CA044579NCRR NIH HHS S10 RR026799NIAID NIH HHS R01 AI116725NIDDK NIH HHS K01 DK088967NIDDK NIH HHS K01 DK091444NIDDK NIH HHS R01 DK062324NIDDK NIH HHS R01 DK085259NIDDK NIH HHS R01 DK104963NIDDK NIH HHS R01 DK105133NIDDK NIH HHS R01 DK105833
6 · The paper itself

Abstract

CD4

Indexed as

Acute Kidney InjuryAnimalsCD4 Lymphocyte CountCell ProliferationCells, CulturedCisplatinCoculture TechniquesDoxorubicinInterleukin-1 Receptor-Like 1 ProteinInterleukin-2Interleukin-33KidneyMaleMiceRecombinant Fusion ProteinsReperfusion InjuryCisplatinDoxorubicinIl1rl1 protein, mouseIL233 fusion proteinInterleukin-1 Receptor-Like 1 ProteinInterleukin-2Interleukin-33Recombinant Fusion ProteinsAKIILC2InflammationIRInephrotoxicityTregs

Identifiers

PMID28539382
PMCPMC5576940
OpenAlexW2618671021

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.