Evidence map›Paper›PMID 28539364›Full record

ArticleThe Journal of biological chemistry2017

Integrative proteomics and biochemical analyses define Ptc6p as the

Xiao Guo, Natalie M Niemi, Joshua J Coon, David J Pagliarini

Open access · hybridAbstract readComparative Study
In one paragraph

Article in The Journal of biological chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.6field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 30 citations in OpenAlex.

  1. Article
  2. Sustained loss ofbioRxiv : the preprint server for biology · 2026
    Article
  3. Article
  4. Coordinating BNIP3/NIX-mediated mitophagy in space and time.Biochemical Society transactions · 2024
    Review
  5. Article
  6. Article
  7. Increased CONature communications · 2024
    Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Xiao GuoMorgridge Institute for Research, Madison, Wisconsin 53715; Departments of Chemistry, University of Wisconsin-Madison, Madison, Wisconsin 53706.
Natalie M NiemiMorgridge Institute for Research, Madison, Wisconsin 53715; Departments of Biochemistry, University of Wisconsin-Madison, Madison, Wisconsin 53706.
Joshua J CoonMorgridge Institute for Research, Madison, Wisconsin 53715; Departments of Chemistry, University of Wisconsin-Madison, Madison, Wisconsin 53706; Genome Center of Wisconsin, Madison, Wisconsin 53706; Biomolecular Chemistry, University of Wisconsin-Madison, Madison, Wisconsin 53706.
David J PagliariniMorgridge Institute for Research, Madison, Wisconsin 53715; Departments of Biochemistry, University of Wisconsin-Madison, Madison, Wisconsin 53706. Electronic address: dpagliarini@morgridge.org.
University of Wisconsin–Madison · US

Funding

Structure, Function and Regulation of the ProteomeR35GM118110 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI COON, JOSHUA J · 2016 to 2025
$9.1M
Regulation of Mitochondrial Metabolism by Post-Translational ModificationsR01DK098672 · NIDDK · WASHINGTON UNIVERSITY · PI David J Pagliarini · 2013 to 2026
$4.8M
NIDDK NIH HHS R01 DK098672NIGMS NIH HHS R35 GM118110
6 · The paper itself

Abstract

The pyruvate dehydrogenase complex (PDC) is the primary metabolic checkpoint connecting glycolysis and mitochondrial oxidative phosphorylation and is important for maintaining cellular and organismal glucose homeostasis. Phosphorylation of the PDC E1 subunit was identified as a key inhibitory modification in bovine tissue ∼50 years ago, and this regulatory process is now known to be conserved throughout evolution. Although

Indexed as

Protein Processing, Post-TranslationalAmino Acid SequenceBiochemistryConserved SequenceDatabases, ProteinEnzyme ActivationGene Knockout TechniquesImmunoprecipitationPhosphoprotein PhosphatasesPhosphorylationPhylogenyProteomicsPyruvate Dehydrogenase ComplexRecombinant Fusion ProteinsSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsPhosphoprotein PhosphatasesPTC6 protein, S cerevisiaePyruvate Dehydrogenase ComplexRecombinant Fusion ProteinsSaccharomyces cerevisiae ProteinsGpd1pmitochondriaphosphoproteomicsphosphorylationprotein phosphatase 2C (PP2C)Ptc5pPtc6pPtc7ppyruvate dehydrogenase complex (PDC)Saccharomyces cerevisiae

Identifiers

PMID28539364
PMCPMC5512070
OpenAlexW2618883567

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.