Observational studyJornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia
Tuberculosis recurrence in a priority city in the state of São Paulo, Brazil.
Observational study in Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 8 citations in OpenAlex.
- Identifying risk factors for recurrent multidrug resistant tuberculosis based on patient's record data from 2016 to 2021: retrospective study.Scientific reports · 2024Article
- Timing of recurrence after treatment of pulmonary TB.IJTLD open · 2024Article
- Recurrence Rate of Pulmonary Tuberculosis in Patients Treated with the Standard 6-Month Regimen: Findings and Implications from a Prospective Observational Multicenter Study.Tropical medicine and infectious disease · 2023Article
- Factors affecting successful antituberculosis treatment: a single-center experience.Revista da Associacao Medica Brasileira (1992) · 2023Article
- Risk factors associated with tuberculosis recurrence in South Korea determined using a nationwide cohort study.PloS one · 2022Article
- A new combination rule for Spatial Decision Support Systems for epidemiology.International journal of health geographics · 2019Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objective: To describe cases of tuberculosis recurrence (TBR), stratified by temporal classification (early or late TBR), and to identify possible predictors of such recurrence.
methods: This was an analytical retrospective observational epidemiological study involving a cohort of 963 new cases of pulmonary tuberculosis, reported and treated via the Tuberculosis Control Program in the city of Carapicuíba, Brazil. The study period was from 2000 to 2010. All of the pulmonary tuberculosis patients who successfully completed the treatment (with or without confirmation of cure) were selected and followed until December 31, 2012.
results: Of the 963 cases, TBR occurred in 47 (4.88%). The mean time between the first and second tuberculosis episodes was 36.12 months. Of the 47 TBR cases, 16 (34.04%) occurred within the first 18 months after the completion of the initial treatment (early TBR) and 31 (65.96%) occurred thereafter (late TBR). There were statistically significant differences between the early and late TBR groups only regarding level of education (≤ 3 vs. > 3 years of schooling; p < 0.004) and weight gain at completion of the initial treatment (1.78 kg vs. 5.31 kg; p < 0.045)-not regarding any of the other variables studied.
conclusions: A low level of education might translate to poor treatment adherence, which impedes the killing of bacilli and facilitates their survival in a latent state, making it appear as if the treatment was effective. Minimal or no weight gain at completion of the initial treatment might be a reliable biomarker to be used by health care facilities that provide tuberculosis treatment. OBJETIVO:: Descrever os casos de recorrência de tuberculose (RTB) e identificar possíveis preditores segundo a classificação RTB recente ou tardia. MÉTODOS:: Estudo epidemiológico observacional analítico retrospectivo a partir de uma coorte de 963 casos novos de tuberculose pulmonar notificados e tratados no Programa de Controle de Tuberculose de Carapicuíba (SP). O período de estudo foi de 2000 a 2010. Todos os casos novos de tuberculose pulmonar que completaram com sucesso o tratamento (com ou sem cura confirmada) foram selecionados e seguidos até 31 de dezembro de 2012. RESULTADOS:: Dos 963 casos, RTB ocorreu em 47 (4,88%). O tempo médio transcorrido até o segundo episódio foi de 36,12 meses. Dos 47 casos de RTB, 16 (34,04%) ocorreram em até 18 meses da alta do primeiro tratamento (RTB recente), e 31 (65,96%) ocorreram após 18 meses (RTB tardia). Entre as variáveis investigadas, somente houve diferenças significativas entre os grupos RTB recente e tardia em relação ao ganho de peso na alta do primeiro tratamento (1,78 kg vs. 5,31 kg; p < 0,045) e nível de escolaridade (≤ 3 vs. > 3 anos de estudo; p < 0,004). CONCLUSÕES:: A baixa escolaridade pode indicar uma menor adesão ao tratamento, dificultando a esterilização dos bacilos e facilitando sua sobrevivência em forma dormente, o que mascara a efetividade do tratamento. A ausência ou um reduzido aumento de peso na alta do tratamento poderá servir como um marcador biológico que pode ser utilizado pelos serviços de saúde que realizam o tratamento de tuberculose.
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