ArticleNature2017
Zika virus evolution and spread in the Americas.
Abstract read
In one paragraph
Article in Nature, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 227 papers, 4 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
227citing papers in PubMed, 4 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
227 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- The increasing complexity of arbovirus serology: An in-depth systematic review on cross-reactivity.PLoS neglected tropical diseases · 2023Pooled it
- Update on the Transmission of Zika Virus Through Breast Milk and Breastfeeding: A Systematic Review of the Evidence.Viruses · 2021Pooled it
- Another piece of the Zika puzzle: assessing the associated factors to microcephaly in a systematic review and meta-analysis.BMC public health · 2020Pooled it
- Zika virus infection in the genital tract of non-pregnant females: a systematic review.Revista do Instituto de Medicina Tropical de Sao Paulo · 2020Pooled it
- Acute Zika virus infection in an asymptomatic blood donor at the onset of the Puerto Rico epidemic.Transfusion · 2019Trial
- Article
- Targeting the Zika virus envelope domains I and III as a recombinant vaccine protects mice from lethal challenge.NPJ vaccines · 2026Article
- Identification and full genome sequencing of previously unknown sandfly-borne phleboviruses using a newly established capture-based next-generation sequencing approach.Journal of clinical microbiology · 2026Article
- E-protein variability in Zika virus strains: A possible new O-glycosylation site and its implications.The Indian journal of medical research · 2026Article
- Genomic evidence of HMPV resurgence in Beijing: Clade B2 triggers the 2024 winter epidemic peak.Virologica Sinica · 2026Article
- Zika Virus: A Tale of Two Lineages.Pathogens (Basel, Switzerland) · 2025Review
- Chronic Neuroplasticity Changes Following Neurotropic Viral Infection: Mechanisms and Implications.Cellular and molecular neurobiology · 2025Review
- Viral Metagenomic Next-Generation Sequencing for One Health Discovery and Surveillance of (Re)Emerging Viruses: A Deep Review.International journal of molecular sciences · 2025Review
- A Pyrido-Quinoxaline Derivative That Downregulates Reticulon 3 Protein Exhibits Potent Antiviral Activity Against Zika Virus.Journal of medical virology · 2025Article
- Emergence of Oropouche Virus in Espírito Santo State, Brazil, 2024.Emerging infectious diseases · 2025Article
- varVAMP: degenerate primer design for tiled full genome sequencing and qPCR.Nature communications · 2025Article
- Article
- Comprehensive intra-host infection kinetics reveals high arbo-orthoflavivirus transmission potential by neglected vector species, Aedes scutellaris.PLoS neglected tropical diseases · 2025Article
- Review of selected mosquito-borne diseases: arboviruses (dengue, chikungunya, Zika, West Nile, Japanese encephalitis, yellow fever) and parasitic diseases (malaria, lymphatic Filariasis).Frontiers in public health · 2025Review
- Zika virus infection disturbs development of human muscle progenitor cells.Frontiers in cellular and infection microbiology · 2025Article
167 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
65 authors.
Hayden C MetskyBroad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
Christian B MatrangaBroad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
Shirlee WohlBroad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
Stephen F SchaffnerBroad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
Catherine A FreijeBroad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
Sarah M WinnickiBroad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
Kendra WestBroad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
James QuBroad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
Mary Lynn BanieckiBroad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
Adrianne Gladden-YoungBroad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
Aaron E LinBroad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
Christopher H Tomkins-TinchBroad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
Simon H YeBroad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
Daniel J ParkBroad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
Cynthia Y LuoBroad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
Kayla G BarnesBroad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
Rickey R ShahBroad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
Bridget ChakBroad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
Giselle Barbosa-LimaNational Institute of Infectious Diseases Evandro Chagas, Fundação Oswaldo Cruz (FIOCRUZ), Rio de Janeiro, Rio de Janeiro, Brazil.
Edson DelatorreLaboratório de AIDS e Imunologia Molecular, Instituto Oswaldo Cruz, FIOCRUZ, Rio de Janeiro, Rio de Janeiro, Brazil.
Yasmine R VieiraNational Institute of Infectious Diseases Evandro Chagas, Fundação Oswaldo Cruz (FIOCRUZ), Rio de Janeiro, Rio de Janeiro, Brazil.
Lauren M PaulDepartment of Biological Sciences, College of Arts and Sciences, Florida Gulf Coast University, Fort Myers, Florida, USA.
Amanda L TanDepartment of Biological Sciences, College of Arts and Sciences, Florida Gulf Coast University, Fort Myers, Florida, USA.
Carolyn M BarcellonaDepartment of Biological Sciences, College of Arts and Sciences, Florida Gulf Coast University, Fort Myers, Florida, USA.
Mario C PorcelliMiami-Dade County Mosquito Control, Miami, Florida, USA.
Chalmers VasquezMiami-Dade County Mosquito Control, Miami, Florida, USA.
Andrew C CannonsBureau of Public Health Laboratories, Division of Disease Control and Health Protection, Florida Department of Health, Tampa, Florida, USA.
Marshall R ConeBureau of Public Health Laboratories, Division of Disease Control and Health Protection, Florida Department of Health, Tampa, Florida, USA.
Kelly N HoganBureau of Public Health Laboratories, Division of Disease Control and Health Protection, Florida Department of Health, Tampa, Florida, USA.
Edgar W KoppBureau of Public Health Laboratories, Division of Disease Control and Health Protection, Florida Department of Health, Tampa, Florida, USA.
Joshua J AnzingerDepartment of Microbiology, The University of the West Indies, Mona, Kingston, Jamaica.
Kimberly F GarciaInstituto de Investigacion en Microbiologia, Universidad Nacional Autónoma de Honduras, Tegucigalpa, Honduras.
Leda A ParhamInstituto de Investigacion en Microbiologia, Universidad Nacional Autónoma de Honduras, Tegucigalpa, Honduras.
Rosa M Gélvez RamírezGrupo de Epidemiología Clínica, Universidad Industrial de Santander, Bucaramanga, Colombia.
Maria C Miranda MontoyaGrupo de Epidemiología Clínica, Universidad Industrial de Santander, Bucaramanga, Colombia.
Diana P RojasDepartment of Epidemiology, College of Public Health and Health Professions, University of Florida, Gainesville, Florida, USA.
Catherine M BrownMassachusetts Department of Public Health, Jamaica Plain, Massachusetts, USA.
Scott HenniganMassachusetts Department of Public Health, Jamaica Plain, Massachusetts, USA.
Brandon SabinaMassachusetts Department of Public Health, Jamaica Plain, Massachusetts, USA.
Sarah ScotlandMassachusetts Department of Public Health, Jamaica Plain, Massachusetts, USA.
Karthik GangavarapuDepartment of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, USA.
Nathan D GrubaughDepartment of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, USA.
Glenn OliveiraScripps Translational Science Institute, La Jolla, California, USA.
Refugio Robles-SikisakaDepartment of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, USA.
Andrew RambautInstitute of Evolutionary Biology, University of Edinburgh, Edinburgh EH9 3FL, UK.
Lee GehrkeInstitute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
Sandra SmoleMassachusetts Department of Public Health, Jamaica Plain, Massachusetts, USA.
M Elizabeth HalloranVaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
Luis VillarGrupo de Epidemiología Clínica, Universidad Industrial de Santander, Bucaramanga, Colombia.
Salim MattarInstitute for Tropical Biology Research, Universidad de Córdoba, Montería, Córdoba, Colombia.
Ivette LorenzanaInstituto de Investigacion en Microbiologia, Universidad Nacional Autónoma de Honduras, Tegucigalpa, Honduras.
Jose Cerbino-NetoNational Institute of Infectious Diseases Evandro Chagas, Fundação Oswaldo Cruz (FIOCRUZ), Rio de Janeiro, Rio de Janeiro, Brazil.
Clarissa ValimDepartment of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Harvard University, Boston, Massachusetts, USA.
Wim DegraveFIOCRUZ, Instituto Oswaldo Cruz, Laboratório de Genômica Funcional e Bioinformática, Rio de Janeiro, Rio de Janeiro, Brazil.
Patricia T BozzaLaboratório de Imunofarmacologia, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Rio de Janeiro, Brazil.
Andreas GnirkeBroad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
Kristian G AndersenDepartment of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, USA.
Sharon IsernDepartment of Biological Sciences, College of Arts and Sciences, Florida Gulf Coast University, Fort Myers, Florida, USA.
Scott F MichaelDepartment of Biological Sciences, College of Arts and Sciences, Florida Gulf Coast University, Fort Myers, Florida, USA.
Fernando A BozzaNational Institute of Infectious Diseases Evandro Chagas, Fundação Oswaldo Cruz (FIOCRUZ), Rio de Janeiro, Rio de Janeiro, Brazil.
Thiago M L SouzaNational Institute for Science and Technology on Innovation on Neglected Diseases, FIOCRUZ, Rio de Janeiro, Rio de Janeiro, Brazil.
Irene BoschInstitute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
Nathan L YozwiakBroad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
Bronwyn L MacInnisBroad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
Pardis C SabetiBroad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
Funding
Viral Genomics: evolution, spread, and host interactionsU19AI110818 · NIAID · BROAD INSTITUTE, INC. · PI CUOMO, CHRISTINA A · 2014 to 2024
$66.5MScripps Translational Science InstituteUL1TR001114 · NCATS · SCRIPPS RESEARCH INSTITUTE, THE · PI TOPOL, ERIC JEFFREY · 2013 to 2017
$24.0MUnderstanding Transmission with Integrated Genetic and Epidemiologic InferenceU54GM111274 · NIGMS · FRED HUTCHINSON CANCER RESEARCH CENTER · PI VESPIGNANI, ALESSANDRO · 2014 to 2018
$12.5MPATHOGENESIS AND IMMUNOLOGY OF DISEASET32AI007244 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI NEMAZEE, DAVID · 1985 to 2022
$8.8MDesign of a human monoclonal antibody-informed dengue vaccineR01AI099210 · NIAID · FLORIDA GULF COAST UNIVERSITY · PI ISERN, SHARON · 2013 to 2016
$1.7MMMDx: A rapid multiplexed matrix code diagnostic for real time epidemiologyR33AI100190 · NIAID · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI GEHRKE, LEE · 2014 to 2016
$1.6MMMDx: A rapid multiplexed matrix code diagnostic for real time epidemiologyR21AI100190 · NIAID · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI GEHRKE, LEE · 2012 to 2013
$436kNCATS NIH HHS UL1 TR001114NIAID NIH HHS HHSN272201400048CNIAID NIH HHS R01 AI099210NIAID NIH HHS R21 AI100190NIAID NIH HHS R33 AI100190NIAID NIH HHS T32 AI007244NIAID NIH HHS U19 AI110818NIGMS NIH HHS U54 GM111274Wellcome Trust 206298/Z/17/Z
Abstract
Although the recent Zika virus (ZIKV) epidemic in the Americas and its link to birth defects have attracted a great deal of attention, much remains unknown about ZIKV disease epidemiology and ZIKV evolution, in part owing to a lack of genomic data. Here we address this gap in knowledge by using multiple sequencing approaches to generate 110 ZIKV genomes from clinical and mosquito samples from 10 countries and territories, greatly expanding the observed viral genetic diversity from this outbreak. We analysed the timing and patterns of introductions into distinct geographic regions; our phylogenetic evidence suggests rapid expansion of the outbreak in Brazil and multiple introductions of outbreak strains into Puerto Rico, Honduras, Colombia, other Caribbean islands, and the continental United States. We find that ZIKV circulated undetected in multiple regions for many months before the first locally transmitted cases were confirmed, highlighting the importance of surveillance of viral infections. We identify mutations with possible functional implications for ZIKV biology and pathogenesis, as well as those that might be relevant to the effectiveness of diagnostic tests.
Indexed as
PhylogenyAnimalsBrazilColombiaCulicidaeDisease OutbreaksGenome, ViralGeographic MappingHondurasHumansMetagenomeMolecular EpidemiologyMosquito VectorsMutationPublic Health SurveillancePuerto Rico
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