Evidence map›Paper›PMID 28538730›Full record

ArticleNature2017

Blocking FSH induces thermogenic adipose tissue and reduces body fat.

Peng Liu, Yaoting Ji, Tony Yuen, Elizabeth Rendina-Ruedy, Victoria E DeMambro, Samarth Dhawan, Wahid Abu-Amer, Sudeh Izadmehr, Bin Zhou, Andrew C Shin and 30 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 220 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
220citing papers in PubMed, 2 pooled it
19.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

220 citing papers in PubMed, 2 syntheses or guidelines pooled it, 341 citations in OpenAlex.

  1. Pooled it
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  6. Impact of menopausal hormone formulations on pituitary-ovarian regulatory feedback.American journal of physiology. Regulatory, integrative and comparative physiology · 2019
    Trial
  7. Review
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  19. Article
  20. FSH Signaling in Osteoporosis and Alzheimer's Disease.Current osteoporosis reports · 2026
    Review

160 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

40 authors at 10 institutions in 4 countries.

Peng LiuDepartment of Medicine, and Mount Sinai Bone Program, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
Yaoting JiDepartment of Medicine, and Mount Sinai Bone Program, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
Tony YuenDepartment of Medicine, and Mount Sinai Bone Program, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
Elizabeth Rendina-RuedyMaine Medical Center Research Institute, Scarborough, Maine 04074, USA.
Victoria E DeMambroMaine Medical Center Research Institute, Scarborough, Maine 04074, USA.
Samarth DhawanDepartment of Medicine, and Mount Sinai Bone Program, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
Wahid Abu-AmerDepartment of Medicine, and Mount Sinai Bone Program, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
Sudeh IzadmehrDepartment of Medicine, and Mount Sinai Bone Program, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
Bin ZhouDepartment of Biomedical Engineering, Columbia University, New York, New York 10027, USA.
Andrew C ShinDepartment of Medicine, and Mount Sinai Bone Program, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
Rauf LatifDepartment of Medicine, and Mount Sinai Bone Program, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
Priyanthan ThangeswaranDepartment of Medicine, and Mount Sinai Bone Program, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
Animesh GuptaDepartment of Medicine, and Mount Sinai Bone Program, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
Jianhua LiDepartment of Medicine, and Mount Sinai Bone Program, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
Valeria ShnayderDepartment of Medicine, and Mount Sinai Bone Program, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
Samuel T RobinsonDepartment of Biomedical Engineering, Columbia University, New York, New York 10027, USA.
Yue Eric YuDepartment of Biomedical Engineering, Columbia University, New York, New York 10027, USA.
Xingjian ZhangDepartment of Biomedical Engineering, Columbia University, New York, New York 10027, USA.
Feiran YangDepartment of Biomedical Engineering, Columbia University, New York, New York 10027, USA.
Ping LuDepartment of Medicine, and Mount Sinai Bone Program, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
Yu ZhouDepartment of Medicine, and Mount Sinai Bone Program, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
Ling-Ling ZhuDepartment of Medicine, and Mount Sinai Bone Program, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
Douglas J OberlinDepartment of Medicine, and Mount Sinai Bone Program, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
Terry F DaviesDepartment of Medicine, and Mount Sinai Bone Program, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
Michaela R ReaganMaine Medical Center Research Institute, Scarborough, Maine 04074, USA.
Aaron BrownMaine Medical Center Research Institute, Scarborough, Maine 04074, USA.
T Rajendra KumarDepartment of Obstetrics and Gynecology, University of Colorado School of Medicine, Aurora, Colorado 80045, USA.
Solomon EpsteinDepartment of Medicine, and Mount Sinai Bone Program, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
Jameel IqbalPathology Service, Greater Los Angeles Veterans Affairs Medical Center, Los Angeles, California 90073, USA.
Narayan G AvadhaniDeparment of Animal Biology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, Pennsylvania 19104, USA.
Maria I NewDepartment of Medicine, and Mount Sinai Bone Program, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
Henrik MolinaProteomics Resource Center, Rockefeller University, New York, New York 10065, USA.
Jan B van KlinkenDepartment of Human Genetics and Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, 2311 EZ Leiden, The Netherlands.
Edward X GuoDepartment of Biomedical Engineering, Columbia University, New York, New York 10027, USA.
Christoph BuettnerDepartment of Medicine, and Mount Sinai Bone Program, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
Shozeb HaiderDepartment of Pharmaceutical and Biological Chemistry, University College London School of Pharmacy, London WC1N 1AX, UK.
Zhuan BianSchool and Hospital of Stomatology, Wuhan University, and Key Laboratory of Oral Biomedicine, Ministry of Education, Wuhan, Hubei 430079, China.
Li SunDepartment of Medicine, and Mount Sinai Bone Program, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
Clifford J RosenMaine Medical Center Research Institute, Scarborough, Maine 04074, USA.
Mone ZaidiDepartment of Medicine, and Mount Sinai Bone Program, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
Icahn School of Medicine at Mount Sinai · USColumbia University · USMaine Medical Center Research Institute · USLeiden University Medical Center · NLRockefeller University · USUniversity College London · GBUniversity of Colorado Denver · USUniversity of Pennsylvania · USWest Los Angeles College · USWuhan University · CN

Funding

RESEARCH TRAININGP30DK026687 · NIDDK · ST. LUKE'S-ROOSEVELT INST FOR HLTH SCIS · PI Anthony W Ferrante, DYMPNA GALLAGHER · 1986 to 2026
$33.0M
The Aging Pituitary/Gonadal AxisP01AG029531 · NIA · WICHITA STATE UNIVERSITY · PI GEORGE R BOUSFIELD · 2009 to 2026
$25.9M
Interdisciplinary Study of Marrow Adiposity, Mineral Metabolism & Energy BalanceR24DK092759 · NIDDK · MAINEHEALTH · PI HOROWITZ, MARK C, MACDOUGALD, ORMOND A · 2011 to 2019
$13.0M
Progenitor Cell Analysis CoreP30GM106391 · NIGMS · MAINEHEALTH · PI WOJCHOWSKI, DON MICHAEL · 2013 to 2017
$5.7M
Phase III COBRE in Vascular BiologyP30GM103392 · NIGMS · MAINEHEALTH · PI ST. GERMAIN, DONALD L. · 2012 to 2016
$4.7M
Role of FSH in Osreoclast Formation and FunctionR01AG023176 · NIA · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI ZAIDI, MONE · 2003 to 2012
$4.4M
Ahr and OsteoporosisR01AR067066 · NIAMS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI AVADHANI, NARAYAN G, ZAIDI, MONE · 2014 to 2018
$3.3M
TSH and BoneR01DK080459 · NIDDK · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI DAVIES, TERRY FRANCIS, SUN, LI · 2009 to 2013
$2.8M
Thyrotropin Receptor, Thyrotropin and Mechanisms of Bone LossR01DK113627 · NIDDK · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI DAVIES, TERRY FRANCIS, IQBAL, JAMEEL Z · 2017 to 2020
$2.8M
Understanding the skeletal phenotype of Gaucher diseaseR01AR065932 · NIAMS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI MISTRY, PRAMOD K, ZAIDI, MONE · 2013 to 2017
$2.6M
A Role of Hypothalamic Dysfunction in Alcoholic Liver DiseaseR01AA023416 · NIAAA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI BUETTNER, CHRISTOPH · 2014 to 2018
$2.2M
COBRE in Stem Cell Biology and Regenerative MedicineP20GM103465 · NIGMS · MAINEHEALTH · PI WOJCHOWSKI, DON MICHAEL · 2012 to 2012
$2.0M
NIAAA NIH HHS R01 AA023416NIAMS NIH HHS R01 AR065932NIAMS NIH HHS R01 AR067066NIA NIH HHS P01 AG029531NIA NIH HHS R01 AG023176NIA NIH HHS R01 AG040132NIDDK NIH HHS P30 DK026687NIDDK NIH HHS R01 DK080459NIDDK NIH HHS R01 DK113627NIDDK NIH HHS R24 DK092759NIDDK NIH HHS R56 DK083658NIGMS NIH HHS P20 GM103465NIGMS NIH HHS P30 GM103392NIGMS NIH HHS P30 GM106391NIH HHS AG23176NIH HHS AG40132NIH HHS AR065932NIH HHS AR067066NIH HHS DK113627NIH HHS R24 DK092759-06
6 · The paper itself

Abstract

Menopause is associated with bone loss and enhanced visceral adiposity. A polyclonal antibody that targets the β-subunit of the pituitary hormone follicle-stimulating hormone (Fsh) increases bone mass in mice. Here, we report that this antibody sharply reduces adipose tissue in wild-type mice, phenocopying genetic haploinsufficiency for the Fsh receptor gene Fshr. The antibody also causes profound beiging, increases cellular mitochondrial density, activates brown adipose tissue and enhances thermogenesis. These actions result from the specific binding of the antibody to the β-subunit of Fsh to block its action. Our studies uncover opportunities for simultaneously treating obesity and osteoporosis.

Indexed as

AdiposityThermogenesisAdipocytesAdipose TissueAdipose Tissue, BeigeAdipose Tissue, WhiteAnimalsAntibodiesDiet, High-FatFemaleFollicle Stimulating Hormone, beta SubunitHaploinsufficiencyMaleMiceMitochondriaObesityAntibodiesFollicle Stimulating Hormone, beta SubunitReceptors, FSHUcp1 protein, mouseUncoupling Protein 1

Identifiers

PMID28538730
PMCPMC5651981
OpenAlexW2618352462

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.