Evidence map›Paper›PMID 28538727›Full record

ArticleNature2017

Establishment and cryptic transmission of Zika virus in Brazil and the Americas.

N R Faria, J Quick, I M Claro, J Thézé, J G de Jesus, M Giovanetti, M U G Kraemer, S C Hill, A Black, A C da Costa and 64 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 350 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
350citing papers in PubMed, 2 pooled it
85.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

350 citing papers in PubMed, 2 syntheses or guidelines pooled it, 663 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Nanopore Sequencing for Chikungunya Virus: Principles and Application.Methods in molecular biology (Clifton, N.J.) · 2027
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  10. Genome Sequencing in Infectious Disease Outbreaks.Advances in experimental medicine and biology · 2026
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  17. Review
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  19. Article
  20. Review

290 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

74 authors at 20 institutions in 9 countries.

N R FariaDepartment of Zoology, University of Oxford, Oxford OX1 3SY, UK.
J QuickInstitute of Microbiology and Infection, University of Birmingham, Birmingham, UK.
I M ClaroDepartment of Infectious Disease, School of Medicine &Institute of Tropical Medicine, University of São Paulo, São Paulo, Brazil.
J ThézéDepartment of Zoology, University of Oxford, Oxford OX1 3SY, UK.
J G de JesusFundação Oswaldo Cruz (FIOCRUZ), Salvador, Bahia, Brazil.
M GiovanettiFundação Oswaldo Cruz (FIOCRUZ), Salvador, Bahia, Brazil.
M U G KraemerDepartment of Zoology, University of Oxford, Oxford OX1 3SY, UK.
S C HillDepartment of Zoology, University of Oxford, Oxford OX1 3SY, UK.
A BlackVaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
A C da CostaDepartment of Infectious Disease, School of Medicine &Institute of Tropical Medicine, University of São Paulo, São Paulo, Brazil.
L C FrancoEvandro Chagas Institute, Ministry of Health, Ananindeua, Brazil.
S P SilvaEvandro Chagas Institute, Ministry of Health, Ananindeua, Brazil.
C-H WuDepartment of Statistics, University of Oxford, Oxford OX1 3LB, UK.
J RaghwaniDepartment of Zoology, University of Oxford, Oxford OX1 3SY, UK.
S CauchemezMathematical Modelling of Infectious Diseases and Center of Bioinformatics, Biostatistics and Integrative Biology, Institut Pasteur, Paris, France.
L du PlessisDepartment of Zoology, University of Oxford, Oxford OX1 3SY, UK.
M P VerottiCoordenação dos Laboratórios de Saúde (CGLAB/DEVIT/SVS), Ministry of Health, Brasília, Brazil.
W K de OliveiraCoordenação Geral de Vigilância e Resposta às Emergências em Saúde Pública (CGVR/DEVIT), Ministry of Health, Brasília, Brazil.
E H CarmoDepartamento de Vigilância das Doenças Transmissíveis, Ministry of Health, Brasilia, Brazil.
G E CoelhoCoordenação Geral dos Programas de Controle e Prevenção da Malária e das Doenças Transmitidas pelo Aedes, Ministry of Health, Brasília, Brazil.
A C F S SantelliCoordenação Geral dos Programas de Controle e Prevenção da Malária e das Doenças Transmitidas pelo Aedes, Ministry of Health, Brasília, Brazil.
L C VinhalCoordenação Geral dos Programas de Controle e Prevenção da Malária e das Doenças Transmitidas pelo Aedes, Ministry of Health, Brasília, Brazil.
C M HenriquesDepartamento de Vigilância das Doenças Transmissíveis, Ministry of Health, Brasilia, Brazil.
J T SimpsonOntario Institute for Cancer Research, Toronto, Ontario, Canada.
M LooseUniversity of Nottingham, Nottingham, UK.
K G AndersenDepartment of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California 92037, USA.
N D GrubaughDepartment of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California 92037, USA.
S SomasekarDepartments of Laboratory Medicine and Medicine &Infectious Diseases, University of California, San Francisco, California, USA.
C Y ChiuDepartments of Laboratory Medicine and Medicine &Infectious Diseases, University of California, San Francisco, California, USA.
J E Muñoz-MedinaDivisión de Laboratorios de Vigilancia e Investigación Epidemiológica, Instituto Mexicano del Seguro Social, Ciudad de México, Mexico.
C R Gonzalez-BonillaDivisión de Laboratorios de Vigilancia e Investigación Epidemiológica, Instituto Mexicano del Seguro Social, Ciudad de México, Mexico.
C F AriasInstituto de Biotecnología, Universidad Nacional Autónoma de México, Cuernavaca, Mexico.
L L Lewis-XimenezInstituto Oswaldo Cruz (FIOCRUZ), Rio de Janeiro, Brazil.
S A BaylisPaul-Ehrlich-Institut, Langen, Germany.
A O ChieppeLaboratório Central de Saúde Pública Noel Nutels, Rio de Janeiro, Brazil.
S F AguiarLaboratório Central de Saúde Pública Noel Nutels, Rio de Janeiro, Brazil.
C A FernandesLaboratório Central de Saúde Pública Noel Nutels, Rio de Janeiro, Brazil.
P S LemosEvandro Chagas Institute, Ministry of Health, Ananindeua, Brazil.
B L S NascimentoEvandro Chagas Institute, Ministry of Health, Ananindeua, Brazil.
H A O MonteiroEvandro Chagas Institute, Ministry of Health, Ananindeua, Brazil.
I C SiqueiraFundação Oswaldo Cruz (FIOCRUZ), Salvador, Bahia, Brazil.
M G de QueirozLaboratório Central de Saúde Pública do Estado do Rio Grande do Norte, Natal, Brazil.
T R de SouzaLaboratório Central de Saúde Pública do Estado do Rio Grande do Norte, Natal, Brazil.
J F BezerraLaboratório Central de Saúde Pública do Estado do Rio Grande do Norte, Natal, Brazil.
M R LemosLaboratório Central de Saúde Pública do Estado da Paraíba, João Pessoa, Brazil.
G F PereiraLaboratório Central de Saúde Pública do Estado da Paraíba, João Pessoa, Brazil.
D LoudalLaboratório Central de Saúde Pública do Estado da Paraíba, João Pessoa, Brazil.
L C MouraLaboratório Central de Saúde Pública do Estado da Paraíba, João Pessoa, Brazil.
R DhaliaFundação Oswaldo Cruz (FIOCRUZ), Recife, Pernambuco, Brazil.
R F FrançaFundação Oswaldo Cruz (FIOCRUZ), Recife, Pernambuco, Brazil.
T MagalhãesFundação Oswaldo Cruz (FIOCRUZ), Recife, Pernambuco, Brazil.
E T MarquesFundação Oswaldo Cruz (FIOCRUZ), Recife, Pernambuco, Brazil.
T JaenischSection Clinical Tropical Medicine, Department for Infectious Diseases, Heidelberg University Hospital, Heidelberg, Germany.
G L WallauFundação Oswaldo Cruz (FIOCRUZ), Recife, Pernambuco, Brazil.
M C de LimaLaboratório Central de Saúde Pública do Estado de Alagoas, Maceió, Brazil.
V NascimentoLaboratório Central de Saúde Pública do Estado de Alagoas, Maceió, Brazil.
E M de CerqueiraLaboratório Central de Saúde Pública do Estado de Alagoas, Maceió, Brazil.
M M de LimaUniversidade Estadual de Feira de Santana, Feira de Santana, Bahia, Brazil.
D L MascarenhasSecretaria de Saúde de Feira de Santana, Feira de Santana, Bahia, Brazil.
J P Moura NetoUniversidade Federal do Amazonas, Manaus, Brazil.
A S LevinDepartment of Infectious Disease, School of Medicine &Institute of Tropical Medicine, University of São Paulo, São Paulo, Brazil.
T R Tozetto-MendozaDepartment of Infectious Disease, School of Medicine &Institute of Tropical Medicine, University of São Paulo, São Paulo, Brazil.
S N FonsecaHospital São Francisco, Ribeirão Preto, Brazil.
M C Mendes-CorreaDepartment of Infectious Disease, School of Medicine &Institute of Tropical Medicine, University of São Paulo, São Paulo, Brazil.
F P MilagresUniversidade Federal do Tocantins, Palmas, Brazil.
A SeguradoDepartment of Infectious Disease, School of Medicine &Institute of Tropical Medicine, University of São Paulo, São Paulo, Brazil.
E C HolmesUniversity of Sydney, Sydney, Australia.
A RambautInstitute of Evolutionary Biology, University of Edinburgh, Edinburgh EH9 3FL, UK.
T BedfordVaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
M R T NunesEvandro Chagas Institute, Ministry of Health, Ananindeua, Brazil.
E C SabinoDepartment of Infectious Disease, School of Medicine &Institute of Tropical Medicine, University of São Paulo, São Paulo, Brazil.
L C J AlcantaraFundação Oswaldo Cruz (FIOCRUZ), Salvador, Bahia, Brazil.
N J LomanInstitute of Microbiology and Infection, University of Birmingham, Birmingham, UK.
O G PybusDepartment of Zoology, University of Oxford, Oxford OX1 3SY, UK.
Fundação Oswaldo Cruz · BRMinistério da Saúde · BRUniversidade de São Paulo · BRUniversity of Oxford · GBUniversidade Estadual de Ciências da Saúde de Alagoas · BRInstituto Evandro Chagas · BRMexican Social Security Institute · MXScripps Research Institute · USUniversity of Birmingham · GBUniversity of California, San Francisco · USClinics Hospital of Ribeirão Preto · BRFred Hutch Cancer Center · USHeidelberg University · DEInstitut Pasteur · FRMetabiota (United States) · USNational Institutes of Health · USOntario Institute for Cancer Research · CAPaul Ehrlich Institut · DEThe University of Texas Medical Branch at Galveston · USUniversidade Estadual de Feira de Santana · BR

Funding

PATHOGENESIS AND IMMUNOLOGY OF DISEASET32AI007244 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI NEMAZEE, DAVID · 1985 to 2022
$8.8M
Pan-Genomic Approaches for Comprehensive Blood Screening of Novel or Emerging Infectious AgentsR01HL105704 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHIU, CHARLES YEN · 2011 to 2020
$5.9M
Real-time tracking of virus evolution for vaccine strain selection and epidemiological investigationR35GM119774 · NIGMS · FRED HUTCHINSON CANCER RESEARCH CENTER · PI BEDFORD, TREVOR BC · 2016 to 2025
$4.1M
Real-Time Unbiased Pathogen Detection in Febrile Illnesses by Nanopore SequencingR33AI120977 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHIU, CHARLES YEN · 2018 to 2020
$1.6M
Real-Time Unbiased Pathogen Detection in Febrile Illnesses by Nanopore SequencingR21AI120977 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHIU, CHARLES YEN · 2016 to 2017
$436k
Medical Research Council MC_PC_15100Medical Research Council MR/L015080/1Medical Research Council MR/M501621/1NHLBI NIH HHS R01 HL105704NIAID NIH HHS R21 AI120977NIAID NIH HHS R33 AI120977NIAID NIH HHS T32 AI007244NIGMS NIH HHS R35 GM119774Wellcome Trust 101237/Z/13/ZWellcome Trust 206298/Z/17/ZWellcome Trust MC_PC_15100/ZK/16-078
6 · The paper itself

Abstract

Transmission of Zika virus (ZIKV) in the Americas was first confirmed in May 2015 in northeast Brazil. Brazil has had the highest number of reported ZIKV cases worldwide (more than 200,000 by 24 December 2016) and the most cases associated with microcephaly and other birth defects (2,366 confirmed by 31 December 2016). Since the initial detection of ZIKV in Brazil, more than 45 countries in the Americas have reported local ZIKV transmission, with 24 of these reporting severe ZIKV-associated disease. However, the origin and epidemic history of ZIKV in Brazil and the Americas remain poorly understood, despite the value of this information for interpreting observed trends in reported microcephaly. Here we address this issue by generating 54 complete or partial ZIKV genomes, mostly from Brazil, and reporting data generated by a mobile genomics laboratory that travelled across northeast Brazil in 2016. One sequence represents the earliest confirmed ZIKV infection in Brazil. Analyses of viral genomes with ecological and epidemiological data yield an estimate that ZIKV was present in northeast Brazil by February 2014 and is likely to have disseminated from there, nationally and internationally, before the first detection of ZIKV in the Americas. Estimated dates for the international spread of ZIKV from Brazil indicate the duration of pre-detection cryptic transmission in recipient regions. The role of northeast Brazil in the establishment of ZIKV in the Americas is further supported by geographic analysis of ZIKV transmission potential and by estimates of the basic reproduction number of the virus.

Indexed as

AmericasBasic Reproduction NumberBrazilGenetic VariationGenome, ViralHumansMicrocephalyMolecular EpidemiologyPhylogeographySpatio-Temporal AnalysisZika VirusZika Virus Infection

Identifiers

PMID28538727
PMCPMC5722632
OpenAlexW2618268848

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.