ArticleNature2017
Genomic epidemiology reveals multiple introductions of Zika virus into the United States.
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Article in Nature, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 199 papers, 2 of them syntheses that pooled it.
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199citing papers in PubMed, 2 pooled it
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Who cites it
199 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The Potential Role of Clinical Metagenomics in Infectious Diseases: Therapeutic Perspectives.Drugs · 2021Pooled it
- A systematic review and evaluation of Zika virus forecasting and prediction research during a public health emergency of international concern.PLoS neglected tropical diseases · 2019Pooled it
- Diversity of insect-specific viruses in Culex mosquitoes from Papua New Guinea.Virology journal · 2026Article
- Integrated Bioinformatics and Network Analysis Identifies Key Molecular Targets and Hub Genes in Zika Virus-induced Neuroinflammation.Journal of molecular neuroscience : MN · 2026Article
- Global source-sink dynamics of dengue viruses and epidemic establishment in areas on the fringe of endemic transmission.National science review · 2026Article
- Environmental, climatic, and social risk factors of severe fever with thrombocytopenia syndrome and the implications of climate change.One health (Amsterdam, Netherlands) · 2026Article
- Global epidemiology and evolutionary dynamics of arboviruses: A systematic review of surveillance, control strategies, and emerging threats.Dialogues in health · 2026Review
- SAASI: Sampling Aware Ancestral State Inference.Nature communications · 2026Article
- Frequent introductions and climate suitability drive increasing dengue risk in Florida.medRxiv : the preprint server for health sciences · 2026Article
- Identification and full genome sequencing of previously unknown sandfly-borne phleboviruses using a newly established capture-based next-generation sequencing approach.Journal of clinical microbiology · 2026Article
- First whole-genome detection of dengue virus in urban Aedes aegypti from Southern Brazil.PLoS neglected tropical diseases · 2026Article
- Phylogenetic insights into the transmission dynamics of arthropod-borne viruses.Nature reviews. Genetics · 2026Review
- Phylodynamic analysis reveals disparate transmission dynamics of Mycobacterium tuberculosis complex lineages in Botswana.Scientific reports · 2025Article
- Serological Evidence of Flavivirus Infection Among Mothers of Newborns in El Paso, Texas.Vector borne and zoonotic diseases (Larchmont, N.Y.) · 2025Article
- MASCOT-Skyline integrates population and migration dynamics to enhance phylogeographic reconstructions.PLoS computational biology · 2025Article
- Metagenomic Next-Generation Sequencing in Infectious Diseases: Clinical Applications, Translational Challenges, and Future Directions.Diagnostics (Basel, Switzerland) · 2025Review
- Differential immunity induced by Omicron sublineages in naïve and vaccine breakthrough infections.Scientific reports · 2025Article
- Effect of chikungunya, Mayaro and Una virus coinfection on vector competence ofOne health (Amsterdam, Netherlands) · 2025Article
- Review
- Epidemiology of West Nile Virus in New York City: Trends and Transmission Dynamics (2000-2019).Pathogens (Basel, Switzerland) · 2025Article
139 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
69 authors.
Nathan D GrubaughDepartment of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California 92037, USA.
Jason T LadnerCenter for Genome Sciences, US Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland 21702, USA.
Moritz U G KraemerDepartment of Zoology, University of Oxford, Oxford OX1 3PS, UK.
Gytis DudasVaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA.
Amanda L TanDepartment of Biological Sciences, College of Arts and Sciences, Florida Gulf Coast University, Fort Myers, Florida 33965, USA.
Karthik GangavarapuDepartment of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California 92037, USA.
Michael R WileyCenter for Genome Sciences, US Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland 21702, USA.
Stephen WhiteBureau of Public Health Laboratories, Division of Disease Control and Health Protection, Florida Department of Health, Miami, Florida 33125, USA.
Julien ThézéDepartment of Zoology, University of Oxford, Oxford OX1 3PS, UK.
Diogo M MagnaniDepartment of Pathology, University of Miami Miller School of Medicine, Miami, Florida 33136, USA.
Karla PrietoCenter for Genome Sciences, US Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland 21702, USA.
Daniel ReyesCenter for Genome Sciences, US Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland 21702, USA.
Andrea M BinghamBureau of Epidemiology, Division of Disease Control and Health Protection, Florida Department of Health, Tallahassee, Florida 32399, USA.
Lauren M PaulDepartment of Biological Sciences, College of Arts and Sciences, Florida Gulf Coast University, Fort Myers, Florida 33965, USA.
Refugio Robles-SikisakaDepartment of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California 92037, USA.
Glenn OliveiraScripps Translational Science Institute, La Jolla, California 92037, USA.
Darryl ProntyBureau of Public Health Laboratories, Division of Disease Control and Health Protection, Florida Department of Health, Miami, Florida 33125, USA.
Carolyn M BarcellonaDepartment of Biological Sciences, College of Arts and Sciences, Florida Gulf Coast University, Fort Myers, Florida 33965, USA.
Hayden C MetskyThe Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA.
Mary Lynn BanieckiThe Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA.
Kayla G BarnesThe Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA.
Bridget ChakThe Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA.
Catherine A FreijeThe Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA.
Adrianne Gladden-YoungThe Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA.
Andreas GnirkeThe Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA.
Cynthia LuoThe Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA.
Bronwyn MacInnisThe Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA.
Christian B MatrangaThe Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA.
Daniel J ParkThe Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA.
James QuThe Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA.
Stephen F SchaffnerThe Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA.
Christopher Tomkins-TinchThe Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA.
Kendra L WestThe Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA.
Sarah M WinnickiThe Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA.
Shirlee WohlThe Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA.
Nathan L YozwiakThe Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA.
Joshua QuickInstitute of Microbiology and Infection, University of Birmingham, Birmingham B15 2TT, UK.
Joseph R FauverDepartment of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, Colorado 80523, USA.
Kamran KhanLi Ka Shing Knowledge Institute, St Michael's Hospital, Toronto, Ontario M5B 1T8, Canada.
Shannon E BrentLi Ka Shing Knowledge Institute, St Michael's Hospital, Toronto, Ontario M5B 1T8, Canada.
Robert C ReinerInstitute for Health Metrics and Evaluation, University of Washington, Seattle, Washington 98121, USA.
Paola N LichtenbergerDivision of Infectious Diseases, University of Miami Miller School of Medicine, Miami, Florida 33136, USA.
Michael J RicciardiDepartment of Pathology, University of Miami Miller School of Medicine, Miami, Florida 33136, USA.
Varian K BaileyDepartment of Pathology, University of Miami Miller School of Medicine, Miami, Florida 33136, USA.
David I WatkinsDepartment of Pathology, University of Miami Miller School of Medicine, Miami, Florida 33136, USA.
Marshall R ConeBureau of Public Health Laboratories, Division of Disease Control and Health Protection, Florida Department of Health, Tampa, Florida 33612, USA.
Edgar W KoppBureau of Public Health Laboratories, Division of Disease Control and Health Protection, Florida Department of Health, Tampa, Florida 33612, USA.
Kelly N HoganBureau of Public Health Laboratories, Division of Disease Control and Health Protection, Florida Department of Health, Tampa, Florida 33612, USA.
Andrew C CannonsBureau of Public Health Laboratories, Division of Disease Control and Health Protection, Florida Department of Health, Tampa, Florida 33612, USA.
Reynald JeanFlorida Department of Health in Miami-Dade County, Miami, Florida 33125, USA.
Andrew J MonaghanNational Center for Atmospheric Research, Boulder, Colorado 80307, USA.
Robert F GarryDepartment of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, Louisiana 70112, USA.
Nicholas J LomanInstitute of Microbiology and Infection, University of Birmingham, Birmingham B15 2TT, UK.
Nuno R FariaDepartment of Zoology, University of Oxford, Oxford OX1 3PS, UK.
Mario C PorcelliMiami-Dade County Mosquito Control, Miami, Florida 33178, USA.
Chalmers VasquezMiami-Dade County Mosquito Control, Miami, Florida 33178, USA.
Elyse R NagleCenter for Genome Sciences, US Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland 21702, USA.
Derek A T CummingsDepartment of Biology and Emerging Pathogens Institute, University of Florida, Gainesville, Florida 32610, USA.
Danielle StanekBureau of Epidemiology, Division of Disease Control and Health Protection, Florida Department of Health, Tallahassee, Florida 32399, USA.
Andrew RambautInstitute of Evolutionary Biology, University of Edinburgh, Edinburgh EH9 3FL, UK.
Mariano Sanchez-LockhartCenter for Genome Sciences, US Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland 21702, USA.
Pardis C SabetiThe Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA.
Leah D GillisBureau of Public Health Laboratories, Division of Disease Control and Health Protection, Florida Department of Health, Miami, Florida 33125, USA.
Scott F MichaelDepartment of Biological Sciences, College of Arts and Sciences, Florida Gulf Coast University, Fort Myers, Florida 33965, USA.
Trevor BedfordVaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA.
Oliver G PybusDepartment of Zoology, University of Oxford, Oxford OX1 3PS, UK.
Sharon IsernDepartment of Biological Sciences, College of Arts and Sciences, Florida Gulf Coast University, Fort Myers, Florida 33965, USA.
Gustavo PalaciosCenter for Genome Sciences, US Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland 21702, USA.
Kristian G AndersenDepartment of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California 92037, USA.
Funding
Scripps Translational Science InstituteUL1TR001114 · NCATS · SCRIPPS RESEARCH INSTITUTE, THE · PI TOPOL, ERIC JEFFREY · 2013 to 2017
$24.0MMiami Clinical and Translational Science InstituteUL1TR000460 · NCATS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI SACCO, RALPH L. · 2012 to 2016
$16.9MTraining, Outreach & Diversity ComponentU54GM088491 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI VAN PANHUIS, WILLEM GIJSBERT · 2009 to 2018
$16.7MPATHOGENESIS AND IMMUNOLOGY OF DISEASET32AI007244 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI NEMAZEE, DAVID · 1985 to 2022
$8.8MReal-time tracking of virus evolution for vaccine strain selection and epidemiological investigationR35GM119774 · NIGMS · FRED HUTCHINSON CANCER RESEARCH CENTER · PI BEDFORD, TREVOR BC · 2016 to 2025
$4.1MProject 2. Expansion of Clinical Research Capacity at Kenema Government HospitalU19AI115589 · NIAID · TULANE UNIVERSITY OF LOUISIANA · PI SCHIEFFELIN, JOHN SCRIBNER · 2015 to 2019
$3.6MDesign of a human monoclonal antibody-informed dengue vaccineR01AI099210 · NIAID · FLORIDA GULF COAST UNIVERSITY · PI ISERN, SHARON · 2013 to 2016
$1.7MFHCRC High-Performance Computing ClusterS10OD020069 · OD · FRED HUTCHINSON CANCER RESEARCH CENTER · PI KOOPERBERG, CHARLES L · 2015 to 2015
$600kACL HHS U01CK000510European Research Council 260864Medical Research Council MC_PC_15100Medical Research Council MR/L015080/1Medical Research Council MR/M501621/1NCATS NIH HHS UL1 TR000460NCATS NIH HHS UL1 TR001114NCEZID CDC HHS U01 CK000510NIAID NIH HHS HHSN272201400048CNIAID NIH HHS R01 AI099210NIAID NIH HHS T32 AI007244NIAID NIH HHS U19 AI115589NIGMS NIH HHS R35 GM119774NIGMS NIH HHS U54 GM088491NIH HHS S10 OD020069Wellcome Trust 206298/Z/17/Z
Abstract
Zika virus (ZIKV) is causing an unprecedented epidemic linked to severe congenital abnormalities. In July 2016, mosquito-borne ZIKV transmission was reported in the continental United States; since then, hundreds of locally acquired infections have been reported in Florida. To gain insights into the timing, source, and likely route(s) of ZIKV introduction, we tracked the virus from its first detection in Florida by sequencing ZIKV genomes from infected patients and Aedes aegypti mosquitoes. We show that at least 4 introductions, but potentially as many as 40, contributed to the outbreak in Florida and that local transmission is likely to have started in the spring of 2016-several months before its initial detection. By analysing surveillance and genetic data, we show that ZIKV moved among transmission zones in Miami. Our analyses show that most introductions were linked to the Caribbean, a finding corroborated by the high incidence rates and traffic volumes from the region into the Miami area. Our study provides an understanding of how ZIKV initiates transmission in new regions.
Indexed as
AedesAnimalsCaribbean RegionDisease OutbreaksFemaleFloridaGenome, ViralHumansIncidenceMolecular EpidemiologyMosquito VectorsZika VirusZika Virus Infection
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.