Evidence map›Paper›PMID 28538683›Full record

ReviewMetabolites2017

Metabolic Investigations of the Molecular Mechanisms Associated with Parkinson's Disease.

Robert Powers, Shulei Lei, Annadurai Anandhan, Darrell D Marshall, Bradley Worley, Ronald L Cerny, Eric D Dodds, Yuting Huang, Mihalis I Panayiotidis, Aglaia Pappa and 1 more

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Metabolites, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 58 citations in OpenAlex.

  1. Review
  2. Article
  3. ACS pharmacology & translational science · 2025
    Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Review
  10. Article
  11. Review
  12. Review
  13. Review
  14. Review
  15. Article
  16. Article
  17. Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 3 countries.

Robert PowersDepartment of Chemistry, University of Nebraska-Lincoln, Lincoln, NE 68588, USA. rpowers3@unl.edu.
Shulei LeiDepartment of Chemistry, University of Nebraska-Lincoln, Lincoln, NE 68588, USA. shulei@huskers.unl.edu.
Annadurai AnandhanRedox Biology Center, University of Nebraska-Lincoln, Lincoln, NE 68588, USA. ananbiochem@gmail.com.
Darrell D MarshallDepartment of Chemistry, University of Nebraska-Lincoln, Lincoln, NE 68588, USA. darrell.marshall@huskers.unl.edu.
Bradley WorleyDepartment of Chemistry, University of Nebraska-Lincoln, Lincoln, NE 68588, USA. bradley.worley@huskers.unl.edu.
Ronald L CernyDepartment of Chemistry, University of Nebraska-Lincoln, Lincoln, NE 68588, USA. rcerny1@unl.edu.
Eric D DoddsDepartment of Chemistry, University of Nebraska-Lincoln, Lincoln, NE 68588, USA. eric.dodds@unl.edu.
Yuting HuangDepartment of Chemistry, University of Nebraska-Lincoln, Lincoln, NE 68588, USA. yuting.huang@huskers.unl.edu.
Mihalis I PanayiotidisDepartment of Applied Sciences, Northumbria University, Newcastle Upon Tyne NE1 8ST, UK. m.panagiotidis@northumbria.ac.uk.
Aglaia PappaDepartment of Molecular Biology and Genetics, Democritus University of Thrace, Alexandroupolis 68100, Greece. apappa@mbg.duth.gr.
Rodrigo FrancoRedox Biology Center, University of Nebraska-Lincoln, Lincoln, NE 68588, USA. rfrancocruz2@unl.edu.
University of Nebraska–Lincoln · USDemocritus University of Thrace · GRNorthumbria University · GB

Funding

Targeted mass spectrometry approaches to understand CART processing and recepter interactionsP20GM113126 · NIGMS · UNIVERSITY OF NEBRASKA LINCOLN · PI GUO, JIANTAO · 2016 to 2025
$20.8M
NIGMS NIH HHS P20 GM113126
6 · The paper itself

Abstract

Parkinson's disease (PD) is a neurodegenerative disorder characterized by fibrillar cytoplasmic aggregates of α-synuclein (i.e., Lewy bodies) and the associated loss of dopaminergic cells in the substantia nigra. Mutations in genes such as α-synuclein (

Indexed as

geneticsmass spectrometrymolecular mechanismsNMRParkinson’s Diseasetoxin synergy

Identifiers

PMID28538683
PMCPMC5487993
OpenAlexW2620533407

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.