Evidence map›Paper›PMID 28538625›Full record

ArticleThe journal of trauma and acute care surgery2017

A metric of our own: Failure to rescue after trauma.

Daniel N Holena, Elinore J Kaufman, M Kit Delgado, Douglas J Wiebe, Brendan G Carr, Jason D Christie, Patrick M Reilly

Open access · greenAbstract read
In one paragraph

Article in The journal of trauma and acute care surgery, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 22 citations in OpenAlex.

  1. Complications and Their Association with Mortality Following Emergency Gastrointestinal Surgery-an Observational Study.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2022
    Observational
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Failure to rescue in surgical patients: A review for acute care surgeons.The journal of trauma and acute care surgery · 2019
    Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Daniel N HolenaFrom the Division of Traumatology (D.N.H., P.M.R.), Surgical Critical Care and Emergency Surgery, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania; The Penn Injury Science Center at the University of Pennsylvania (D.N.H., M.K.D., D.J.W., P.M.R.), Philadelphia, Pennsylvania; Department of Surgery (E.J.K.), Weill-Cornell School of Medicine, New York, New York; Department of Emergency Medicine (M.K.D.), Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania; Center for Clinical Epidemiology and Biostatistics (D.J.W.), Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania; and Department of Emergency Medicine (B.G.C.), Jefferson University School of Medicine, Philadelphia, Pennsylvania.
Elinore J Kaufman
M Kit Delgado
Douglas J Wiebe
Brendan G Carr
Jason D Christie
Patrick M Reilly
Cornell University · US

Funding

Enabling Medical Research Growth in Emergency MedicineK12HL109009 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI KIMMEL, STEPHEN E. · 2011 to 2015
$3.4M
The Penn Violence and Injury Control Research CenterR49CE002474 · CE · UNIVERSITY OF PENNSYLVANIA · PI WIEBE, DOUGLAS J · 2014 to 2018
$2.2M
Reducing mortality attributable to cardiac and pulmonary complications after traumatic injury: understanding the role of failure-to-rescueK08HL131995 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI HOLENA, DANIEL NORMAN · 2016 to 2018
$509k
NCIPC CDC HHS R49 CE002474NHLBI NIH HHS K08 HL131995NHLBI NIH HHS K12 HL109009
6 · The paper itself

Abstract

backgroundFailure to rescue (FTR) is defined as death after an adverse event. The original metric was derived in elective surgical populations and reclassifies deaths not preceded by recorded adverse events as FTR cases under the assumption these deaths resulted from missed adverse events. This approach lacks face validity in trauma because patients often die without adverse events as a direct result of injury. Another common approach simply excludes deaths without recorded adverse events, but this approach reduces the reliability of the FTR metric. We hypothesized that a hybrid metric excluding expected deaths but otherwise including patients without recorded adverse events in FTR analysis would improve face validity and reliability relative to existing methods.

methodsUsing 3 years of single-state adult trauma registry data from 30 trauma centers, we constructed 3 FTR metrics: (1) excluding deaths not preceded by adverse events (FTR-E), (2) reclassifying deaths not preceded by adverse events (FTR-R), and (3) including deaths not preceded by adverse events in FTR analysis except those with predicted mortality or greater than 50% (FTR-T). Mortality, adverse event, and FTR rates were calculated under each method, and reliability was tested using Spearman correlation for split-sample center rankings.

resultsA total of 89,780 patients were included (median age, 57 years [interquartile range, 26-73 years]; 85% were white; 59% were male; 92% had blunt mechanism of injury; median Injury Severity Score, 9 [interquartile range, 5-14]). The FTR rates varied by metric (FTR-E, 11.2%; FTR-R, 31.2%; FTR-T, 21.4%), as did the proportion of deaths preceded by adverse events (FTR-E, 28%; FTR-R, 100%; FTR-T, 60%). Spit-sample reliability was higher FTR-T than FTR-E (ρ = 0.59 vs. = 0.27, p < 0.001).

conclusionsA trauma-specific FTR metric increases face validity and reliability relative to other FTR methods that may be used in trauma populations. Future trauma outcomes studies examining FTR rates should use a metric designed for this cohort. LEVEL OF EVIDENCE: Retrospective cohort study, outcomes, level III.

Indexed as

Hospital MortalityTrauma CentersAdultAgedFemaleHumansMaleMiddle AgedPennsylvaniaRegistriesRetrospective StudiesTrauma Severity IndicesTreatment FailureWounds and Injuries

Identifiers

PMID28538625
PMCPMC5608646
OpenAlexW2617268172

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.