Observational studyMedicine2017
Serum PLR and LMR in Behçet's disease: Can they show the disease activity?
Observational study in Medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03747354 (Serum), which is not on this map. Cited by 22 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Serum (PLR), (LMR), (MPV) and (NLR) in Behcet Disease and Their Correlation With Disease Activity
Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 46 citations in OpenAlex.
- Role of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio as potential biomarkers in Behçet's disease: a meta-analysis.Zeitschrift fur Rheumatologie · 2024Pooled it
- Finding the Needle in the Haystack: Serological and Urinary Biomarkers in Behçet's Disease: A Systematic Review.International journal of molecular sciences · 2023Pooled it
- The relationship between hematological indices of systemic inflammation and disease activity in patients with rheumatoid arthritis: a retrospective cross-sectional study.Clinical rheumatology · 2026Article
- Application Value of Platelet-to-Lymphocyte Ratio as a Novel Indicator in Rheumatoid Arthritis: A Review Based on Clinical Evidence.Journal of inflammation research · 2024Review
- High levels of plateletZhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2022Article
- Assessing the role of systemic inflammation in the etiopathogenesis of advanced stage keratoconus.Indian journal of ophthalmology · 2021Article
- Monocyte-to-lymphocyte ratio is associated with 28-day mortality in patients with acute respiratory distress syndrome: a retrospective study.Journal of intensive care · 2021Article
- Correlation of clinical signs and symptoms of Behçet's disease with platelet-to-lymphocyte ratio (PLR) and neutrophil-to-lymphocyte ratio (NLR).Immunologic research · 2021Article
- Variation of red blood cell parameters in Behcet's disease: association with disease severity and vascular involvement.Clinical rheumatology · 2021Article
- Risk factors of disease activity in patients with Behçet's syndrome.Clinical rheumatology · 2021Article
- Severe retinopathy of prematurity is associated with early post-natal low platelet count.Scientific reports · 2021Article
- Use of prognostic nutritional index in the evaluation of disease activity in patients with Behçet's disease.European journal of rheumatology · 2020Article
- An investigation of thiol/disulfide homeostasis in patients with Behçet's disease.Archives of medical science : AMS · 2020Article
- High Monocyte-To-Lymphocyte Ratio Is Associated With Stroke-Associated Pneumonia.Frontiers in neurology · 2020Article
- Value of hematological indices versus VEGF as biomarkers of activity in Behçet's disease.Clinical rheumatology · 2019Article
- The Platelet-to-Lymphocyte Ratio as an Inflammatory Marker in Rheumatic Diseases.Annals of laboratory medicine · 2019Review
- Neutrophil-to-lymphocyte and platelet-to-lymphocyte ratio as predictors of 12-week treatment response and drug persistence of anti-tumor necrosis factor-α agents in patients with rheumatoid arthritis: a retrospective chart review analysis.Rheumatology international · 2019Article
- Biomarkers in Vasculitides of the Nervous System.Frontiers in neurology · 2019Review
- Serum calprotectin and ischemia modified albumin levels as markers of disease activity in Behçet's disease.Postepy dermatologii i alergologii · 2018Article
- Platelet to lymphocyte ratio is associated with the current activity of ANCA-associated vasculitis at diagnosis: a retrospective monocentric study.Rheumatology international · 2018Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study is to determine platelet to lymphocyte ratio (PLR) and lymphocytes to monocytes ratio (LMR) levels in Behçet's disease (BD) and to investigate their relationships with disease activity.Hematological and inflammatory parameters including high-sensitivity C-reactive proteins (hs-CRP), erythrocyte sedimentation rate (ESR), PLR, and LMR were examined in BD and healthy controls.Data from 140 patients with BD (108 with active and 32 with inactive disease) and 107 controls were enrolled. PLR (153.21 ± 65.44, 106.20 ± 28.91, P <.001, respectively) was remarkably higher, whereas LMR (5.37 ± 5.47, 8.95 ± 5.84, P <.001, respectively) was significantly lower in BD than in controls. Active BD patients had significantly higher PLR (159.20 vs 131.14, P = .037), ESR (38.30 vs 24.55, P = .017), and hs-CRP (30.20 vs 17.21, P = .027) than those with inactive BD. However, no significant difference in LMR was found between the groups. Moreover, PLR was positively correlated with BDCAF (r = 0.193, P <.05), hs-CRP (r = 0.402, P <.01), and ESR (r = 0.284, P <.01), whereas LMR was negatively correlated with BDCAF (r = -0.175, P <.05), hs-CPR (r = -0.263, P <.01), and ESR (r = -0.175, P <.05). Additionally, both PLR and LMR were shown to be independent factors for BD by multivariate logistic regression analysis. Furthermore, a PLR level of 124.63 was determined as the best cut-off value by ROC analysis (sensitivity 64.3%, specificity 78.0%, and the area under the ROC curve 0. 753).PLR was elevated in active BD as compared to inactive BD. PLR may be a reliable, cost-effective, and novel potential parameter to help evaluate disease activity in BD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.