Trial reportMedicine2017
Characteristics of and risk factors for severe neurological deficit in patients with pyogenic vertebral osteomyelitis: A case-control study.
Trial report in Medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 58 citations in OpenAlex.
- Isolated Staphylococcus aureus spinal epidural abscesses: severe initial neurological deficits do not predict worse outcomes compared with spondylodiscitis-associated cases.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Article
- Beyond Cord Compression: Instability as a Major Driver for Neurological Deficit in Active Thoracic Spinal Tuberculosis.Global spine journal · 2026Article
- Using C-Reactive Protein Measurements to Predict Treatment Failure in Native Vertebral Osteomyelitis: A Multisite Retrospective Cohort Study Cohort Study.Open forum infectious diseases · 2026Article
- Cervical myelopathy caused by vertebral osteomyelitis after below-knee amputation for diabetic foot: A case report on early diagnosis and rehabilitation.Turkish journal of physical medicine and rehabilitation · 2026Article
- Clinical features of pyogenic vertebral osteomyelitis and factors associated with adverse clinical outcome: a retrospective cohort study.BMC infectious diseases · 2025Article
- Changing Tides in the Treatment of Spondylodiscitis? A Retrospective, Monocentric Comparison of Mortality and Quality of Life After Surgical and Conservative Treatment.Clinics and practice · 2025Article
- Diagnosis and management of de novo non-specific spinal infections: European Association of Neurosurgical Societies (EANS) Spine Section Delphi consensus recommendations.Brain & spine · 2025Article
- Unique Presentation of Asymptomatic Bacteriuria, Vertebral Osteomyelitis, and Iliopsoas Abscess Due to Klebsiella pneumonia in a 73-Year-Old Man with Type 2 Diabetes Mellitus on Empagliflozin.The American journal of case reports · 2024Article
- The Need for Comprehensive Medical Management in Pyogenic Spondylodiscitis: A Review Article.Spine surgery and related research · 2024Review
- Early Reduction in C-Reactive Protein Following Treatment for Spinal Epidural Abscess: A Potential Treatment Guide.Global spine journal · 2024Article
- Advances in diagnosis and management of atypical spinal infections: A comprehensive review.North American Spine Society journal · 2023Article
- Preoperative Risk Factors Affecting Outcome in Surgically Treated Pyogenic Spondylodiscitis.Global spine journal · 2023Article
- Spinal cord injury as a result of Staphylococcus aureus pyogenic spinal infection complicating infected atopic eczema: two case reports.Spinal cord series and cases · 2023Article
- Can we predict favourable quality of life after surgically treated vertebral osteomyelitis? Analysis of a prospective study.Archives of orthopaedic and trauma surgery · 2023Article
- Determining threshold values for success after surgical treatment of lumbar spondylodiscitis using quality of life scores.Acta orthopaedica et traumatologica turcica · 2023Article
- Candida: The Ruthless Opportunist.Cureus · 2023Article
- Carbapenem-ResistantInfection and drug resistance · 2023Article
- Utilization of Antibiotic Bone Cement in Spine Surgery: Pearls, Techniques, and Case Review.Orthopedic reviews · 2023Article
- Spinal infection with intraspinal abscess or empyema and acute myelopathy: comparative analysis of diagnostics, therapy, complications and outcome in primary care.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2022Article
- Machine learning is an effective method to predict the 90-day prognosis of patients with transient ischemic attack and minor stroke.BMC medical research methodology · 2022Article
Corrections and comments
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Authors and funding
17 authors at 12 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Severe neurological deficit (SND) is a rare but major complication of pyogenic vertebral osteomyelitis (PVO). We aimed to determine the risk factors and the variables associated with clinical improvement for SND during PVO.This case-control study included patients without PVO-associated SND enrolled in a prospective randomized antibiotic duration study, and patients with PVO-associated SND managed in 8 French referral centers. Risk factors for SND were determined by logistic regression.Ninety-seven patients with PVO-associated SND cases, and 297 controls were included. Risk factors for SND were epidural abscess [adjusted odds ratio, aOR 8.9 (3.8-21)], cervical [aOR 8.2 (2.8-24)], and/or thoracic involvement [aOR 14.8 (5.6-39)], Staphylococcus aureus PVO [aOR 2.5 (1.1-5.3)], and C-reactive protein (CRP) >150 mg/L [aOR 4.1 (1.9-9)]. Among the 81 patients with PVO-associated SND who were evaluated at 3 months, 62% had a favorable outcome, defined as a modified Rankin score ≤ 3. No factor was found significantly associated with good outcome, whereas high Charlson index [adjusted Hazard Ratio (aHR) 0.3 (0.1-0.9)], low American Spinal Injury Association (ASIA) impairment scale at diagnosis [aHR 0.4 (0.2-0.9)], and thoracic spinal cord compression [aHR 0.2 (0.08-0.5)] were associated with poor outcome. Duration of antibiotic treatment was not associated with functional outcome.SND is more common in cervical, thoracic, and S. aureus PVO, in the presence of epidural abscess, and when CRP >150 mg/L. Although neurological deterioration occurs in 30% of patients in early follow-up, the functional outcome is quite favorable in most cases after 3 months. The precise impact of optimal surgery and/or corticosteroids therapy must be specified by further studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.