ArticleCell reports2017
Tonic LAT-HDAC7 Signals Sustain Nur77 and Irf4 Expression to Tune Naive CD4 T Cells.
Open access · goldAbstract read
In one paragraph
Article in Cell reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 39 citations in OpenAlex.
- Finding functional gaps: integrative analysis of VPAC1- and VPAC2-mediated signalling pathways in human lymphocytes.Cell & bioscience · 2026Article
- The LDH-H3K18La-Nur77 Axis Potentiates Immune Escape in Small Cell Lung Cancer.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Targeting the nuclear orphan receptor NR4A1: a key target in lung cancer progression and therapeutic resistance.Frontiers in oncology · 2025Review
- Endogenous antigens shape the transcriptome and TCR repertoire in an autoimmune arthritis model.The Journal of clinical investigation · 2024Article
- Class IIa HDAC4 and HDAC7 cooperatively regulate gene transcription in Th17 cell differentiation.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Cbl-b mitigates the responsiveness of naive CD8Science signaling · 2024Article
- Defective LAT signalosome pathology in mice mimics human IgG4-related disease at single-cell level.The Journal of experimental medicine · 2023Article
- Histone deacetylase 7: a signalling hub controlling development, inflammation, metabolism and disease.The FEBS journal · 2023Review
- Alternative splicing of HDAC7 regulates its interaction with 14-3-3 proteins to alter histone marks and target gene expression.Cell reports · 2023Article
- Role of Histone Deacetylases in T-Cell Development and Function.International journal of molecular sciences · 2022Review
- ZAP70, too little, too much can lead to autoimmunity.Immunological reviews · 2022Review
- KLF2 up-regulates IRF4/HDAC7 to protect neonatal rats from hypoxic-ischemic brain damage.Cell death discovery · 2022Article
- Functional heterogeneity and adaptation of naive T cells in response to tonic TCR signals.Current opinion in immunology · 2021Review
- T cells at work: How post-transcriptional mechanisms control T cell homeostasis and activation.European journal of immunology · 2021Review
- The Effects of Interferons on Allogeneic T Cell Response in GVHD: The Multifaced Biology and Epigenetic Regulations.Frontiers in immunology · 2021Review
- Acetylation in Tumor Immune Evasion Regulation.Frontiers in pharmacology · 2021Review
- Strength of tonic T cell receptor signaling instructs T follicular helper cell-fate decisions.Nature immunology · 2020Article
- Nur77 controls tolerance induction, terminal differentiation, and effector functions in semi-invariant natural killer T cells.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Article
- Role of the Orphan Nuclear Receptor NR4A Family in T-Cell Biology.Frontiers in endocrinology · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 4 institutions in 1 country.
Darienne R MyersDepartment of Anatomy, University of California, San Francisco, San Francisco, CA 94143, USA.
Tannia LauDepartment of Anatomy, University of California, San Francisco, San Francisco, CA 94143, USA.
Evan MarkegardDepartment of Anatomy, University of California, San Francisco, San Francisco, CA 94143, USA.
Hyung W LimGladstone Institute of Virology and Immunology, University of California, San Francisco, 1650 Owens Street, San Francisco, CA 94158, USA.
Herbert KaslerGladstone Institute of Virology and Immunology, University of California, San Francisco, 1650 Owens Street, San Francisco, CA 94158, USA.
Minghua ZhuDepartment of Immunology, Duke University Medical Center, Durham, NC 27710, USA.
Andrea BarczakLung Biology Center, Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA.
John P HuizarDivision of Rheumatology, Rosalind Russell and Ephraim P. Engleman Arthritis Research Center, Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA.
Julie ZikhermanDivision of Rheumatology, Rosalind Russell and Ephraim P. Engleman Arthritis Research Center, Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA.
David J ErleLung Biology Center, Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA.
Weiguo ZhangDepartment of Immunology, Duke University Medical Center, Durham, NC 27710, USA.
Eric VerdinGladstone Institute of Virology and Immunology, University of California, San Francisco, 1650 Owens Street, San Francisco, CA 94158, USA.
Jeroen P RooseDepartment of Anatomy, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address: jeroen.roose@ucsf.edu.
University of California, San Francisco · USDuke Medical Center · USDuke University Hospital · USGladstone Institutes · US
Funding
Understand the metabolic fitness of naïve T cellsP01AI091580 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ARTHUR WEISS · 2011 to 2026
$31.1MAnalysis of adaptor protein (LAT) in TCR signalingR01AI048674 · NIAID · DUKE UNIVERSITY · PI ZHANG, WEIGUO · 2001 to 2011
$3.5MLoss of Intrinsic Control in Autoimmune T Helper Cells with Signaling VariantsR01AI104789 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ROOSE, JEROEN · 2014 to 2018
$1.9MDissecting unique functions of IgM and IgD BCRs in tolerance and autoimmunityR01AR069520 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ZIKHERMAN, JULIE · 2016 to 2020
$1.7MNIAID NIH HHS P01 AI091580NIAID NIH HHS R01 AI048674NIAID NIH HHS R01 AI104789NIAMS NIH HHS R01 AR069520
Abstract
CD4
Indexed as
Signal TransductionAdaptor Proteins, Signal TransducingAnimalsCD4-Positive T-LymphocytesCell NucleusCell ProliferationGene DeletionGene Expression RegulationHistone DeacetylasesHumansInterferon Regulatory Factor-4Interferon Regulatory FactorsJurkat CellsMembrane ProteinsMiceNuclear Receptor Subfamily 4, Group A, Member 1Adaptor Proteins, Signal TransducingHDAC7 protein, humanHistone DeacetylasesInterferon Regulatory Factor-4Interferon Regulatory FactorsLAT protein, humanMembrane ProteinsNuclear Receptor Subfamily 4, Group A, Member 1gene expressionHDACIrf4LATNur77T cellsTh2tonic signals
Identifiers
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.