ReviewCurrent opinion in neurology2017
Measuring compensation in neurodegeneration using MRI.
Review in Current opinion in neurology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed.
- Brain-clinical biotyping in patients with idiopathic REM sleep behavior disorder.NPJ Parkinson's disease · 2025Article
- Cerebellar Metabolic Connectivity during Treadmill Walking before and after Unilateral Dopamine Depletion in Rats.International journal of molecular sciences · 2024Article
- Measuring Articulatory Patterns in Amyotrophic Lateral Sclerosis Using a Data-Driven Articulatory Consonant Distinctiveness Space Approach.Journal of speech, language, and hearing research : JSLHR · 2023Article
- Accumulation of network redundancy marks the early stage of Alzheimer's disease.Human brain mapping · 2023Article
- A whole new world: embracing the systems-level to understand the indirect impact of pathology in neurodegenerative disorders.Journal of neurology · 2023Review
- Prediction of mental effort derived from an automated vocal biomarker using machine learning in a large-scale remote sample.Frontiers in artificial intelligence · 2023Article
- Investigating Compensatory Brain Activity in Older Adults with Subjective Cognitive Decline.Journal of Alzheimer's disease : JAD · 2023Article
- Compensatory cognition in neurological diseases and aging: A review of animal and human studies.Aging brain · 2023Review
- Classification of Parkinson's disease using a region-of-interest- and resting-state functional magnetic resonance imaging-based radiomics approach.Brain imaging and behavior · 2022Article
- White matter microstructural differences in children and genetic risk for multiple sclerosis: A population-based study.Multiple sclerosis (Houndmills, Basingstoke, England) · 2022Article
- Dopamine depletion and subcortical dysfunction disrupt cortical synchronization and metastability affecting cognitive function in Parkinson's disease.Human brain mapping · 2022Article
- Functional connectivity in Parkinson's disease candidates for deep brain stimulation.NPJ Parkinson's disease · 2022Article
- Linking α-synuclein-induced synaptopathy and neural network dysfunction in early Parkinson's disease.Brain communications · 2022Review
- Differentiating white matter measures that protect against vs. predispose to bipolar disorder and other psychopathology in at-risk youth.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Article
- Association of specific biotypes in patients with Parkinson disease and disease progression.Neurology · 2020Article
- Aberrant functional connectivity of the cingulate subregions in right-sided temporal lobe epilepsy.Experimental and therapeutic medicine · 2020Article
- The Clinical Non-Motor Connectome in Early Parkinson's Disease.Journal of Parkinson's disease · 2020Article
- Assessing inter-individual differences with task-related functional neuroimaging.Nature human behaviour · 2019Review
- Severe hyposmia and aberrant functional connectivity in cognitively normal Parkinson's disease.PloS one · 2018Article
- Altered Whole-Brain and Network-Based Functional Connectivity in Parkinson's Disease.Frontiers in neurology · 2018Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
purpose of reviewDespite signs of cortical and subcortical loss, patients with prodromal and early-stage neurodegenerative disease are able to perform at a level comparable to the normal population. It is presumed that the onset of compensatory processes, that is changes in brain activation within a function-specific network or in the recruitment of a region outside of the task-network, underlies this maintenance of normal performance. However, in most studies to date, increased brain activity is not correlated with indices of both disease and performance and what appears to be compensation could simply be a symptom of neurodegeneration. RECENT
findingsMRI studies have explored compensation in neurodegenerative disease, claiming that compensation is evident across a number of disorders, including Alzheimer's and Parkinson's disease, but generally always in early stages; after this point, compensation is generally no longer able to operate under the severe burden of disease. However, none of these studies explicitly adopted a particular model of compensation. Thus, we also discuss our recent attempts to operationalize compensation for empirical testing. SUMMARY: There is clear evidence of compensatory processes in the early stages of neurodegenerative disease. However, for a more complete understanding, this requires more explicit empirical modelling.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.