ArticleThe American journal of bioethics : AJOB2017
When Respecting Autonomy Is Harmful: A Clinically Useful Approach to the Nocebo Effect.
Article in The American journal of bioethics : AJOB, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed.
- Nocebo effects by providing informed consent in shared decision making? Not necessarily: a randomized pilot-trial using an open-label placebo approach.BMC medical ethics · 2020Trial
- Trial
- The "Are You OK?" Paradox: A Scoping Review of Nocebo and Negative Suggestion in Healthcare Communication.Dentistry journal · 2026Review
- Virtual Reality-Assisted Informed Consent for Anesthesia: A Prospective and Randomized Proof-of-Concept Study.Journal of clinical medicine · 2024Article
- Avoidance of nocebo effects by coincident naming of treatment benefits during the medical interview for informed consent-Evidence from dynamometry.Frontiers in psychology · 2022Article
- Are We Meeting the Current Standards of Consent for Anesthesia? An International Survey of Clinical Practice.Medical science monitor : international medical journal of experimental and clinical research · 2020Article
- [Placebos and placeboids in clinical practice: conceptual and ethical considerations].Der Nervenarzt · 2020Review
- Article
- One-year results after transitioning from etanercept originator to biosimilar in a setting promoting shared decision-making in rheumatology.Rheumatology advances in practice · 2020Article
- Placebos as a Source of Agency: Evidence and Implications.Frontiers in psychiatry · 2019Review
- Tell Me the Truth and I Will Not Be Harmed: Informed Consents and Nocebo Effects.The American journal of bioethics : AJOB · 2017Article
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nocebo effects occur when an adverse effect on the patient arises from the patient's own negative expectations. In accordance with informed consent, providers often disclose information that results in unintended adverse outcomes for the patient. While this may adhere to the principle of autonomy, it violates the doctrine of "primum non nocere," given that side-effect disclosure may cause those side effects. In this article we build off previous work, particularly by Wells and Kaptchuk ( 2012 ) and by Cohen ( 2013 ), to suggest ethical guidelines that permit nondisclosure in the case when a nocebo effect is likely to occur on of the basis of nonmaleficence. We accept that that autonomy vis-à-vis informed consent must be forestalled, but salvage much of its role by elaborating a practical clinical approach to postencounter follow-up. In doing so, we reconcile a clinically practicable process of determining conditions of disclosure with long-standing ethical commitments to patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.