Evidence map›Paper›PMID 28537558›Full record

ArticleeLife2017

Rapid short-term reorganization in the language network.

Gesa Hartwigsen, Danilo Bzdok, Maren Klein, Max Wawrzyniak, Anika Stockert, Katrin Wrede, Joseph Classen, Dorothee Saur

Abstract read
In one paragraph

Article in eLife, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Review
  16. Article
  17. Article
  18. Causal evidence for a coordinated temporal interplay within the language network.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  19. Inhibitory TMS over Visual Area V5/MT Disrupts Visual Speech Recognition.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Gesa HartwigsenDepartment of Neuropsychology, Max Planck Institute for Human Cognitive and Brain Sciences Leipzig, Leipzig, Germany.ORCID 0000-0002-8084-1330
Danilo BzdokDepartment of Psychiatry, Psychotherapy and Psychosomatics, RWTH Aachen, Aachen, Germany.ORCID 0000-0003-3466-6620
Maren KleinLanguage and Aphasia Laboratory, Department of Neurology, University of Leipzig, Leipzig, Germany.
Max WawrzyniakLanguage and Aphasia Laboratory, Department of Neurology, University of Leipzig, Leipzig, Germany.
Anika StockertLanguage and Aphasia Laboratory, Department of Neurology, University of Leipzig, Leipzig, Germany.
Katrin WredeLanguage and Aphasia Laboratory, Department of Neurology, University of Leipzig, Leipzig, Germany.
Joseph ClassenHuman Cortical Physiology and Motor Control Laboratory, Department of Neurology, University of Leipzig, Leipzig, Germany.
Dorothee SaurLanguage and Aphasia Laboratory, Department of Neurology, University of Leipzig, Leipzig, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The adaptive potential of the language network to compensate for lesions remains elusive. We show that perturbation of a semantic region in the healthy brain induced suppression of activity in a large semantic network and upregulation of neighbouring phonological areas. After perturbation, the disrupted area increased its inhibitory influence on another semantic key node. The inhibitory influence predicted the individual delay in response speed, indicating that inhibition at remote nodes is functionally relevant. Individual disruption predicted the upregulation of semantic activity in phonological regions. In contrast, perturbation over a phonological region suppressed activity in the network and disrupted behaviour without inducing upregulation. The beneficial contribution of a neighbouring network might thus depend on the level of functional disruption and may be interpreted to reflect a differential compensatory potential of distinct language networks. These results might reveal generic mechanisms of plasticity in cognitive networks and inform models of language reorganization.

Indexed as

CognitionLanguageNeuronal PlasticityAdultBrainFemaleHumansMaleNerve NetStrokeYoung Adultaphasiahumanlesionneuroscienceparietal cortexsemanticstroketranscranial magnetic stimulation

Identifiers

PMID28537558
PMCPMC5472437

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.