ArticleEuro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin2017
Household transmission of invasive group A Streptococcus infections in England: a population-based study, 2009, 2011 to 2013.
Article in Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 68 citations in OpenAlex.
- Systematic Review of Household Transmission of Strep A: A Potential Site for Prevention That Has Eluded Attention.The Journal of infectious diseases · 2024Pooled it
- Acute rheumatic fever and rheumatic heart disease in Latin America: a contemporary review of epidemiology.Lancet regional health. Americas · 2026Review
- Risk of Household Secondary Invasive Group A Streptococcal Infections After a Prophylaxis Policy Change.JAMA network open · 2026Article
- Choosing Wisely: Effectiveness and Safety of Antibiotic Prophylaxis in Close Contacts of Invasive Group A Streptococci Infection.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2025Article
- Strep A: challenges, opportunities, vaccine-based solutions, and economics.NPJ vaccines · 2024Review
- Increase in invasive group A streptococcal disease among Australian children coinciding with northern hemisphere surges.The Lancet regional health. Western Pacific · 2023Article
- Group A Streptococcus Infection in Neonatal Population: A Systematic Review of The Literature.Journal of clinical medicine · 2023Review
- Effectiveness and Safety of Antibiotic Prophylaxis for Persons Exposed to Cases of Invasive Group A Streptococcal Disease: A Systematic Review.Open forum infectious diseases · 2022Review
- Genital Tract GAS Infection ISIDOG Guidelines.Journal of clinical medicine · 2021Review
- Diverse disease processes of group ABMJ case reports · 2021Article
- Modes of transmission and attack rates of group A Streptococcal infection: a protocol for a systematic review and meta-analysis.Systematic reviews · 2021Article
- A Review ofPathogens (Basel, Switzerland) · 2021Review
- Increasing Incidence of Invasive Group A Streptococcus Disease in First Nations Population, Alberta, Canada, 2003-2017.Emerging infectious diseases · 2021Article
- Invasive Group A Streptococcal Infections: Benefit of Clindamycin, Intravenous Immunoglobulins and Secondary Prophylaxis.Frontiers in pediatrics · 2021Review
- Out-of-season increase of puerperal fever with group AEuro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2020Article
- Biphasic Outbreak of Invasive Group A Streptococcus Disease in Eldercare Facility, New Zealand.Emerging infectious diseases · 2020Article
- Evaluating Household Transmission of Invasive Group A Streptococcus Disease in the United States Using Population-based Surveillance Data, 2013-2016.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2020Article
- InvasiveFrontiers in pediatrics · 2020Article
- Increased Risk for Invasive Group A Streptococcus Disease for Household Contacts of Scarlet Fever Cases, England, 2011-2016.Emerging infectious diseases · 2019Article
- Familial Transmission of emm12 Group A Streptococcus.Emerging infectious diseases · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Invasive group A streptococcal infection has a 15% case fatality rate and a risk of secondary transmission. This retrospective study used two national data sources from England; enhanced surveillance (2009) and a case management system (2011-2013) to identify clusters of severe group A streptococcal disease. Twenty-four household pairs were identified. The median onset interval between cases was 2 days (range 0-28) with simultaneous onset in eight pairs. The attack rate during the 30 days after first exposure to a primary case was 4,520 per 100,000 person-years at risk (95% confidence interval (CI): 2,900-6,730) a 1,940 (95% CI: 1,240-2,880) fold elevation over the background incidence. The theoretical number needed to treat to prevent one secondary case using antibiotic prophylaxis was 271 overall (95% CI: 194-454), 50 for mother-neonate pairs (95% CI: 27-393) and 82 for couples aged 75 years and over (95% CI: 46-417). While a dramatically increased risk of infection was noted in all household contacts, increased risk was greatest for mother-neonate pairs and couples aged 75 and over, suggesting targeted prophylaxis could be considered. Offering prophylaxis is challenging due to the short time interval between cases emphasising the importance of immediate notification and assessment of contacts.
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