ArticleOrganic letters2017
Stereoselective Synthesis of Quaternary Pyrrolidine-2,3-diones and β-Amino Acids.
Article in Organic letters, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 32 citations in OpenAlex.
- Improved Library of Pyrrolidine-2,3-dione Monomers as Antimicrobial and Antibiofilm Agents againstACS medicinal chemistry letters · 2026Article
- Synthesis ofTetrahedron · 2025Article
- Pyrrolidine-2,3-diones: heterocyclic scaffolds that inhibit and eradicateChemical communications (Cambridge, England) · 2024Article
- Synthesis of SpiropyrrolinesThe Journal of organic chemistry · 2024Article
- Total Synthesis and Microbiological Evaluation of Leopolic Acid A and Analogues.ACS bio & med chem Au · 2024Article
- Expanded library of novel 2,3-pyrrolidinedione analogues exhibit anti-biofilm activity.Bioorganic & medicinal chemistry letters · 2024Article
- Biological Screening and Crystallographic Studies of Hydroxy γ-Lactone Derivatives to Investigate PPARγ Phosphorylation Inhibition.Biomolecules · 2023Article
- Regioselective α-addition of vinylogous α-ketoester enolate in organocatalytic asymmetric Michael reactions: enantioselective synthesis of Rauhut-Currier type products.RSC advances · 2022Article
- Pd-catalyzed [3 + 2] cycloaddition of cyclic ketimines and trimethylenemethanes towardRSC advances · 2021Article
- Rapid synthesis of the core scaffold of crinane and haemanthamine through a multi-component approach.Tetrahedron letters · 2021Article
- Leveraging Marine Natural Products as a Platform to Tackle Bacterial Resistance and Persistence.Accounts of chemical research · 2021Article
- Stereoselective, Multicomponent Approach to Quaternary Substituted Hydroindole Scaffolds.Organic letters · 2020Article
- [1,3]/[1,4]-Sulfur atom migration in β-hydroxyalkylphosphine sulfides.Beilstein journal of organic chemistry · 2020Article
- Discovery of 3-hydroxy-3-pyrrolin-2-one-based mPGES-1 inhibitors using a multi-step virtual screening protocol.MedChemComm · 2018Article
- 3-Hydroxy-1,5-dihydro-2H-pyrrol-2-ones as novel antibacterial scaffolds against methicillin-resistant Staphylococcus aureus.Bioorganic & medicinal chemistry letters · 2018Article
- Direct Access to Highly Functionalized Heterocycles through the Condensation of Cyclic Imines and α-Oxoesters.The Journal of organic chemistry · 2017Article
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2 authors at 1 institution in 1 country.
Funding
Abstract
A facile, diastereoselective synthesis of highly substituted pyrrolidine-2,3-diones is reported, along with the one-step conversion of these heterocycles to novel β-amino acids and further functionalized derivatives. This method involves an unusually mild, one-pot, three-component cyclization/allylation followed by a Claisen rearrangement to provide unusual pyrrolidinone products that are densely functionalized and contain an all-carbon quaternary stereocenter. The reported reaction sequence is operationally simple, exquisitely diastereoselective, and provides gram-scale access to valuable heterocyclic scaffolds and β-amino acids not readily accessible via existing approaches.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.